Clinical trials: Anti-inflammatory Agents
Gingivitis
Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
The burden of chronic gingivitis and periodontitis in the US is disproportionately high among Non-Hispanic Blacks compared to Non-Hispanic Whites.
- Trial name
- NCT00779909
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boston University
Laparoscopic Cholecystectomy
Kidney Function After Pneumoperitoneum and Analgesia
double blind study of kidney function of two groups of adult patients submitted to laparoscopic cholecystectomy and analgesia from tramadol associated to dipyrone or ketorolac
- Trial name
- NCT00914875
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Asthma
The Anti-Inflammatory Effect of Extrafine HFA-Beclometasone Versus HFA-Fluticasone, by Means of Inflammometry
Background Chronic inflammation in peripheral airways plays an important role in the pathophysiology of asthma. Extrafine hydrofluoroalkane (HFA) beclometasone is distinguished from other ICS because of its fine aerosol…
- Trial name
- NCT00402207
- Testing
- extrafine HFA-beclomethasone, HFA-fluticasone
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Maastricht University Medical Center
Pulmonary Disease, Chronic Obstructive
A Study To Investigate The Ability To Use 18FDG PET Scanning To Monitor The Effectiveness Of New Drugs In COPD Patients
It is hypothesised that there is a difference between the uptake of a radioactive substance ([18F]fluorodeoxyglucose (FDG)) in the lungs of patients with Chronic Obstructive Pulmonary Disease (COPD) and healthy volunteers.
- Trial name
- NCT00472264
- Testing
- PET imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Eosinophilic Esophagitis
Expanded Access Protocol for Patients With Eosinophilic Esophagitis
This expanded access program is an open-label, single-arm design where consenting patients may participate up until APT-1011 is commercially available in the relevant regions or the protocol is terminated by the Sponsor.
- Trial name
- NCT05095116
- Testing
- APT-1011 3 mg HS
- Where
- 35 sites in United States
- Sponsor
- Ellodi Pharmaceuticals, LP
Inflammation, Malnutrition
Effects of Camelina Sativa Oil in Free-living Older Adults
The present study aims at evaluating the anti-inflammatory effects of a novel food in older adult volunteers. Briefly, this randomized, double-blind and placebo-controlled study is performed on 91 apparently healthy older adults…
- Conditions
- Inflammation, Malnutrition, Hyperglycemia, Dyslipidemias
- Trial name
- NCT04965948
- Testing
- Novel food snack
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Asthma
Prednisolone Pharmacokinetics in Severe Asthma
The purpose of the study is to evaluate whether severe asthmatic subjects have abnormal prednisolone absorption, and how this might affect the anti-inflammatory effects of prednisolone. The aims of the study are 1.
- Trial name
- NCT00662298
- Testing
- prednisolone
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Osteo Arthritis Knee
Effects of Exercise Versus Topical Agents on Knee Osteoarthritis
Osteoarthritis, a chronic and degenerative joint disease, is the most common type of arthritis and affects more than 300 million adults worldwide.
- Trial name
- NCT05827003
- Testing
- Exercise, Exercise&Topical Agent, Topical Agent
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Osteoarthritis, Knee
Tidal Lavage in Knee Osteoarthritis
This study compared the effects of tidal lavage (washing out) of the knee joint and an imitation lavage procedure in people with knee osteoarthritis.
- Trial name
- NCT00000424
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis, Hepatitis B Reactivation
Entecavir for Biological Agents Associated HBV Reactivation in Inflammatory Arthritis Patients
Antiviral prophylaxis can prevent the risk of biologic agents-associated HBV reactivation in hepatitis B inactive carriers and patients with past HBV infection
- Conditions
- Rheumatoid Arthritis, Hepatitis B Reactivation, Exposure to Hepatitis B Virus
- Trial name
- NCT01907230
- Testing
- Entecavir
- Where
- Taiwan
- Volunteers
- 115 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Postoperative Bariatric Surgery
Use Of Esomeprazole In Postoperative Bariatric Surgery Patients Users And Non-Users Of Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Phase IV, open-label, multicenter, non-randomized, with 2 non-comparative investigational arms study, carried out in morbid obesity patients who had undergone gastric bypass surgery for body weight reduction
- Trial name
- NCT00608712
- Testing
- Esomeprazole
- Volunteers
- 140 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Efficacy of Resistance Exercise and an Anti-Inflammatory Diet on Pain, Disease Activity, Functional Status, and Quality of Life in Patients With Rheumatoid Arthritis
This study aims to examine how resistance exercises and an anti-inflammatory diet affect pain, daily functioning, disease activity, and quality of life in people with rheumatoid arthritis.
- Trial name
- RED-RA (NCT07262112)
- Testing
- Exercise, Diet, Medical management/current medications per standard of care by personal physician.
- Volunteers
- 100 people
- Sponsor
- Berra Yamuç Tanrıöğen
Chronic Prostatitis (CP), Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Bovine Colostrum Efficacy for the Treatment of Chronic Prostatitis Symptoms.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a bothering condition characterized by pain localized to the pelvic, perineal and/or genital area and lower urinary tract symptoms (LUTS).
- Conditions
- Chronic Prostatitis (CP), Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Chronic Prostatitis/ Pelvic Pain Syndrome
- Trial name
- NCT06804083
- Testing
- oral combination of colostrum and Serenoa repens extracts (PROSTYM®)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Clinica Urologica Molinette - Città della Saliute e della Scienza
Chronic Kidney Diseases, Heart Failure
Patient Education Video to Reduce OTC NSAIDs
The goal of this study is to assess the efficacy of a brief 3 to 5-minute educational video on influencing intent to change behavior regarding potentially harmful over-the-counter (OTC) NSAID use in adults with chronic kidney…
- Conditions
- Chronic Kidney Diseases, Heart Failure, Hypertension
- Trial name
- NCT06575205
- Testing
- Educational video
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- Carilion Clinic
Localized Primary Osteoarthritis of Hip, Localized Primary Osteoarthritis of Knee
Phase III Study of CG100649 in Osteoarthritis Patients
6-week Efficacy Study The objective of this study is to prove the safety and non-inferiority of analgesic efficacy of CG100649 2 mg vs. celecoxib 200 mg, and analgesic superiority of CG100649 2 mg vs.
- Trial name
- NCT01765296
- Testing
- CG100649, Celecoxib
- Where
- 14 sites in South Korea
- Volunteers
- 362 people
- Sponsor
- CrystalGenomics, Inc.
Chronic Obstructive Pulmonary Disease
Unrefined Salmon Oil as Dietary Supplement in Patient With Chronic Obstructive Pulmonary Disease
Research has over decades showed that marine food carries nutritional characteristics that promote human health. As seen in epidemiological studies and based on in vitro and in vivo studies, it is hypothesized that unrefined…
- Trial name
- NCT05130294
- Testing
- CARDIO®
- Where
- Norway
- Sponsor
- Hofseth Biocare ASA