Clinical trials: Anti-inflammatory Agents
Third Molar Surgery
Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?
In this study; Among the patients randomized because of severe postoperative sequelae expected as a result of radiological and clinical examinations; nonsteroid antiinflammatory drug prescribed group compared with preoperative…
- Trial name
- NCT04200885
- Testing
- Dexketoprofen Trometamol, Dexamethasone 21-Phosphate, Therapeutic Elastic Bandage
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Non-steroidal Anti-inflammatory (NSAID), Analgesic
Bioequivalence Study to Compare Diclofenac Potassium Coated Tablet Versus Cataflam® 50 Coated Tablet
Randomized, four-way, four-period, fully-replicated, single oral dose, open-label, crossover, bioequivalence study to compare Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium) versus Cataflam® 50 coated tablet (50…
- Conditions
- Non-steroidal Anti-inflammatory (NSAID), Analgesic, Antipyretic
- Trial name
- NCT05082662
- Testing
- Diclofenac Potassium coated tablet (50 mg Diclofenac Potassium), Cataflam® 50 coated tablet
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Acute Coronary Syndrome
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects
The aim of the current study is to evaluate whether treatment with high doses of simvastatin can reduce coagulation activation in patients with acute coronary syndromes and if ezetimibe in conjunction with simvastatin may affect…
- Trial name
- NCT00725829
- Testing
- simvastatin, ezetimibe
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
ACL Reconstruction, Hemarthrosis
Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction.
Tranexamic acid (TXA) is widely used in orthopedic surgery to reduce perioperative blood loss, particularly in total hip and knee arthroplasty, due to its antifibrinolytic mechanism, low cost, broad availability, and established…
- Trial name
- TXA (NCT07332910)
- Testing
- Tranexamic Acid (TXA)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Chirec
Graft-Versus-Host Disease
Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease
This study is designed to collect longitudinal biological samples from patients after hematopoietic cell transplantation (HCT) cared for at multiple bone marrow transplant centers to validate biomarkers of both acute and chronic…
- Trial name
- NCT02194439
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Indiana University
Prostate Cancer
Combined Antiinflammatory and Angiostatic Therapy in Patients With Hormone-refractory Prostate Cancer
The purpose of this study is to evaluate the efficacy, tolerability and safety of a multi-targeted therapy in patients with hormone-refractory prostate cancer.
- Trial name
- INV342 (NCT00427999)
- Testing
- imatinib mesylate, Treosulfane, etoricoxib
- Where
- 10 sites in Germany
- Volunteers
- 67 people
- Sponsor
- Novartis Pharmaceuticals
Tympanic Membrane Perforation
Insulin Intratympanic Application
The objective of the present study was to study the impact of insulin insitu-gel formulation on healing progress after surgical procedures for treatment of dry tympanic membrane perforation for at least three consecutive months.
- Trial name
- NCT07535827
- Testing
- Insulin (Humulin), foam
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deraya University
Intravitreal Injections, IVI
Control of Pain in Intravitreal Injections Using Topical NSAIDs
Intravitreal injections (IVI) are a common form of treatment for multiple retinal pathologies. The investigators hypothesize that an intervention with a topical NSAID will alleviate pain experienced at intravitreal injection…
- Trial name
- COPIVIN (NCT04343222)
- Testing
- Bromfenac, Artificial tears
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Wisconsin, Madison
Patients Undergoing Repeat Peripheral Artery Revascularization
Safety and Preliminary Efficacy Study of an Anti-inflammatory Therapeutic Antibody in Reducing Restenosis.
The purpose of this study is to determine if CV-18C3 will reduce the rate of restenosis or the time to restenosis in patients undergoing repeat peripheral artery revascularization versus controls randomized to standard of care.
- Trial name
- NCT01270945
- Testing
- CV-18C3, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Janssen Research & Development, LLC
IUD Insertion Pain
Oral Ketorolac for IUD Pain Reduction
To determine if oral ketorolac given at different timepoints prior to intrauterine device (IUD) insertion influences pain experienced during this procedure.
- Trial name
- NCT06853327
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Inflammation
A Relative Bioavailability Study of 75mg Indomethacin Extended-Release Capsules
The purpose of this study is to demonstrate the bioequivalence of Indomethacin ER Capsules.
- Trial name
- NCT00858195
- Testing
- Indomethacin 75mg Extended-Release Capsules, Sandoz, Indocin 75mg SR Capsules
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sandoz
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
NSAID (Non-Steroidal Anti-Inflammatory Drug)
Study to Evaluate the Efficacy and Safety of Fexuprazan in Prevention of NSAIDs Induced Peptic Ulcer
The study aims to demonstrate the preventive effect of Fexuprazan 20 mg for peptic ulcer is non-inferior to that of Lansoprazole 15 mg in terms of prevention of peptic ulcer and confirm the safety of Fexuprazan 20 mg.
- Trial name
- NCT07533266
- Testing
- Fexuprazan 20mg, Lansoprazole 15 mg
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Acute Coronary Syndrome, Unstable Angina
Vasoactive and Anti-inflammatory Effects of Prasugrel in Acute Coronary Syndrome
To test the vasoactive and anti-inflammatory effects of prasugrel in patients with acute coronary syndrome endothelial function -as a surrogate parameter of NO bioavailability- and different markers of inflammation, oxidative…
- Trial name
- NCT01774838
- Testing
- Prasugrel, Clopidogrel
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Anterior Cruciate Ligament
Early Anti-inflammatory Treatment in Patients With Acute ACL Tear and Painful Effusions
This research study is designed to allow the investigator to answer many questions about the reasons why anterior cruciate ligament (ACL) injury leads to knee pain and disability and osteoarthritis.
- Trial name
- HEALR (NCT03429140)
- Testing
- Gel-One
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Cale Jacobs, PhD
Pain
Pharmacokinetics & Safety of Diclofenac Potassium Oral Solution in Ped. Subjects (2-12 Yrs) With Mild-Mod. Acute Pain
As part of the Pediatric Research Equity Act (PREA) commitment, the objectives of the study are to characterize the pharmacokinetic (PK) profile and to determine the safety and tolerability of diclofenac potassium oral solution…
- Trial name
- NCT02287350
- Testing
- diclofenac potassium oral solution
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- Depomed
Myocarditis Acute
Non-Steroidal Anti-Inflammatory Drugs in Acute Myocarditis
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of a 3-week ibuprofen tapering regimen compared to conventional analgesic treatment (acetaminophen) in patients with acute…
- Trial name
- INFLAMA (NCT06686862)
- Testing
- ibuprofen
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Migraine, Analgesic Affect
Comparision of the Analgesic Effects of Intravenous Ibuprofen and Tenoxicam in Acute Migraine Attack
The aim of this clinical trial is to compare the efficacy of two different non-steroidal anti-inflammatory analgesic drugs in the palliation of headache in acute migraine attack. The main questions it aims to answer are: 1.
- Conditions
- Migraine, Analgesic Affect, Emergency Medicine
- Trial name
- NCT06786650
- Testing
- Tenoxicam Injectable Product, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
IBD
Clinical and Molecular Phenotyping in IBD
Inflammatory bowel disease (IBD) and psoriasis (Ps) are common, chronic, immune- mediated barrier diseases with shared inflammatory pathways.
- Trial name
- Phen_IBD (NCT02694588)
- Testing
- Infliximab, Vedolizumab
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Schleswig-Holstein
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