Clinical trials: Anti-inflammatory Agents
HIV Infections
Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
Summary: Chloroquine is a medication that in laboratory settings has significant anti-HIV effects in HIV infected T-cells. Chloroquine has been used safely for over 60 years for malaria treatment and prevention, and it also has…
- Trial name
- NCT00308620
- Testing
- chloroquine phosphate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota
Aortic Dissection
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Multicenter Cohort Study) III
Anatomopathological classifications have been well identified in aortic dissection with important therapeutic implications. The authors evaluated the inflammatory response in patients with aortic dissection (AD) and assessed the…
- Trial name
- NCT04918108
- Testing
- inflammatory response
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanjing Medical University
Gastric Ulcers, Duodenal Ulcers
Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)
The purpose of this study is to evaluate the safety of TAK-438, once daily (QD), during long-term concomitant non-steroidal anti-inflammatory drug (NSAID) therapy in patients with a history of gastric or duodenal ulcer who…
- Trial name
- NCT01456260
- Testing
- TAK-438, Lansoprazole
- Where
- 97 sites in Japan
- Volunteers
- 406 people
- Sponsor
- Takeda
Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma
Meloxicam vs Placebo for Mobilization
This research study is evaluating a drug called meloxicam to see if it provides a benefit to people receiving Autologous Hematopoietic Stem Cell Transplantation (AHSCT).
- Conditions
- Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Multiple Myeloma, Hematopoietic Stem Cells
- Trial name
- NCT02003625
- Testing
- GCSF, meloxicam
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Ulcerative Colitis
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
The goal of this clinical trial is to determine the clinical effects of two different dietary fibre supplements, acacia gum (AG) and microcrystalline cellulose (MCC), in patients with ulcerative colitis.
- Trial name
- PAIF-UC (NCT06515210)
- Testing
- Acacia Gum, Microcrystalline Cellulose
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Alberta
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Hypertension, Abdominal Aortic Aneurysm
Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension
Inflammation of the blood vessel plays an important role in the development and growth of a dilated abdominal aorta. An elevated blood pressure leads to an increase in inflammation, therefore blood pressure lowering is an…
- Trial name
- PISA (NCT01425242)
- Testing
- Aliskiren, Amlodipine
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Amsterdam UMC, location VUmc
Oxidative Stress, Inflammation
Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols
The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.
- Trial name
- NCT02494739
- Testing
- Yogurt enriched with polyphenols, Yogurt not enriched with polyphenols
- Where
- Greece
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Oral Lichen Planus, Oral Lichenoid Mucositis
Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.
Oral lichen planus (OLP) is a common chronic autoimmune disease associated with cell-mediated immunological dysfunction. Symptomatic OLP is painful and complete healing is rare.
- Conditions
- Oral Lichen Planus, Oral Lichenoid Mucositis, Oral Lichenoid Reaction
- Trial name
- NCT03509675
- Testing
- Ibuprofen suspension 5mg/100ml
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Washington
IBD
Clinical and Molecular Phenotyping in IBD
Inflammatory bowel disease (IBD) and psoriasis (Ps) are common, chronic, immune- mediated barrier diseases with shared inflammatory pathways.
- Trial name
- Phen_IBD (NCT02694588)
- Testing
- Infliximab, Vedolizumab
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Schleswig-Holstein
Pain Management, Anti-Inflammatory Agents, Non-Steroidal
Effectiveness of Anti-Inflammatory Drugs for Preventing Pain Versus Treating Pain During Medical Abortion From 13 to 22 Weeks at Hung Vuong Hospital
The goal of this clinical trial is to assess the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for prophylactic pain relief compared to on-demand pain relief during medical abortion for pregnancies between 13…
- Conditions
- Pain Management, Anti-Inflammatory Agents, Non-Steroidal, Abortion, Spontaneous
- Trial name
- NCT06696573
- Testing
- Prophylactic NSAID Administration, On-Demand NSAID Administration
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Le Thi Kieu Trang
Diabetes Mellitus, Type 2
Anti-inflammatory Status in DM2 Treated Patients
Diabetes mellitus Type 2 (DMT2) - a progressive insulin secretory defect on the background of insulin resistance - is one of the major risk factors for atherosclerosis, an inflammatory disease of the arterial wall, in which…
- Trial name
- INF-DM2-Ther (NCT04392557)
- Testing
- Metformin / alogliptin Oral Product, Metformin / Pioglitazone Pill, triple therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Catanzaro
Alzheimer Disease
A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study)
The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured…
- Trial name
- NCT00004845
- Testing
- Rofecoxib, Naproxen
- Where
- 40 sites in United States
- Sponsor
- National Institute on Aging (NIA)
Elderly, Older Adults
The PAINFREE Initiative, a Stepped Wedge Cluster Randomized Trial
The PAINFREE (Improving PAIN control following FRactures; towards an Elder-friendly Emergency department) Initiative is a patient-centered multifaceted intervention which aims to improve pain management in patients 75 years and…
- Conditions
- Elderly, Older Adults, Bone Fracture, Emergency Department
- Trial name
- PAINFREE (NCT03082417)
- Testing
- Implementation
- Where
- Canada
- Volunteers
- 1,375 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Postoperative Ileus
Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve
Hypothesis: Electrical stimulation of the abdominal vagus nerve has anti-inflammatory effects which lead to a faster postoperative recovery after abdominal surgery.
- Trial name
- NCT02524626
- Testing
- Vagus stimulation
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- KU Leuven
Hypertension
Anti Inflammatory Treatment of Hypertension
To investigate the anti-inflammatory effect of amlodipine and levamlodipine in the treatment of hypertension
- Trial name
- NCT04740840
- Testing
- Levamlodipine, Amlodipine
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of North Sichuan Medical College
Healthy
Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects
This study aims to evaluate the antioxidant and anti-inflammatory effects of acute and chronic consumption of two sweet orange (Citrus sinensis) varieties-'Rosy Red Valencia', which is rich in carotenoids such as lycopene…
- Trial name
- NCT06944210
- Testing
- 'Rosy Red Valencia' sweet orange, 'Olinda Valencia' sweet oranges
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Aging, Age-related Memory Disorders
The Effect of Dietary Strawberry Supplementation on Older Adults
This study is being conducted to assess the effect of dietary strawberry supplementation on cognition and mobility in older adults.
- Trial name
- NCT02051140
- Testing
- Freeze-dried Strawberry
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA Human Nutrition Research Center on Aging
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Atrial Fibrillation
Anti-inflammatory Effects of Rivaroxaban Versus Dabigatran
The purpose of this study is to evaluate the antiinflammatory effects of rivaroxaban compared with dabigatran in patients with atrial fibrillation.
- Trial name
- RIVAL-AF (NCT02331602)
- Testing
- Rivaroxaban, Dabigatran
- Where
- 16 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Yokohama City University Medical Center
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