Clinical trials: Antibiotic
Perforated Appendicitis, Postoperative Infection
Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy.
- Trial name
- NCT03289351
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Surgery
Pilot Trial of Chlorhexidine Gluconate (CHG) Preoperative Skin Preparation
Pilot study to evaluate and compare activity of CHG preoperative preparation with comparator CHG
- Trial name
- NCT02530554
- Testing
- CHG
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Foot Ulcer, Diabetic, Infection
Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers
This is a phase 3, randomized, controlled, blinded, multicenter study conducted in 3 parallel cohorts of diabetic patients with at least 1 infected foot ulcer.
- Trial name
- COACT-1 (NCT02427802)
- Testing
- Gentamicin collagen sponge
- Where
- 86 sites in United States
- Volunteers
- 612 people
- Sponsor
- Innocoll
Bacteremia
Prophylactic Antimicrobial Catheter Lock
This is a randomized, double blinded, prospective, multicenter, clinical trial of the use of Heparin versus Gentamicin as a pos-dialysis catheter lock solution.
- Trial name
- ALLOCK (NCT00571259)
- Testing
- Heparin 1000U/mL, 4% Sodium Citrate with Gentamicin 320 mcg/mL
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Satellite Healthcare
Chronic Obstructive Pulmonary Disease
Comparison of a Serum PRO-CT Guided Treatment and the Recommended Antibiotic Treatment for COPD
Exacerbations of chronic obstructive pulmonary disease (COPD) are the first cause of admission to Pulmonary Department in Italy and worldwide.
- Trial name
- NCT01125098
- Testing
- PRO-CT values
- Where
- Italy
- Volunteers
- 183 people
- Sponsor
- University of Modena and Reggio Emilia
Surgical Wound Infection
Topical Antibiotic Treatment for Spine Surgical Site Infection
There is considerable interest in using in-wound antibiotics (IWA) to prevent infection after spine surgery. An adequate evaluation of IWA is lacking and prior studies are limited by confounding and bias.
- Trial name
- NCT02776774
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Washington
Multiple Myeloma
Fluoroquinolone Resistance Prevalence Study
This is an exploratory study to determine the prevalence of fluoroquinolone resistance in patients receiving dose-intense melphalan with autologous peripheral blood stem cell (PBSC) transplantation in the treatment of multiple…
- Trial name
- FRE (NCT05824689)
- Where
- 2 sites in United States
- Volunteers
- 124 people
- Sponsor
- Hackensack Meridian Health
Bacterial Recovery of Skin Flora Post-product Application
In Vivo Preoperative Skin Preparation Persistence Evaluation
Evaluate persistent antimicrobial effectiveness of chlorhexidine gluconate containing products on abdominal and inguinal sites following a saline and wipe challenge.
- Trial name
- NCT03155178
- Testing
- 3M CHG/IPA Prep, ChloraPrep
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Length of Pregnancy Prolongation in Hours
Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam
Preterm birth remains a major health concern affecting up to 12% of all live births prior to 37 weeks gestation. As preterm birth can often be associated with infection our proposal is to evaluate in a randomized fashion…
- Trial name
- NCT00589329
- Testing
- erythromycin and metronidazole (antibiotics)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Bacterial Pneumonia
Clinical Trials to Reduce the Risk of Antimicrobial Resistance
The primary objective of this study is to demonstrate a low rate of emergence of antibiotic resistance in P. aeruginosa and Acinetobacter spp during the treatment of hospitalized patients with pneumonia requiring mechanical…
- Trial name
- NCT01570192
- Testing
- IV meropenem, I.V. Meropenem, Parenteral aminoglycoside; tobramycin for injection USP OR gentamicin sulfate injection solution concentrate 5mg.kg IV q24h; amikacin sulfate injection USP 20 mg/kg IV q24h
- Where
- 11 sites in United States, France and 2 more
- Volunteers
- 43 people
- Sponsor
- University of Florida
Infection Prevention
Study of Catheter-related Infections Using Antibiotic-coated Versus Conventional Catheters in Children
The primary purpose of the study is to determine if a therapeutic difference exists between central venous catheters impregnated with minocycline and rifampin and conventional catheters not impregnated with antibiotics when used…
- Trial name
- NCT00370149
- Testing
- Antibiotic-impregnated Catheters (M/R), Non-impregnated Catheters (C/S)
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- Indiana University
Corneal Ulcer, Fungal Keratitis
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers.
- Trial name
- MALIN (NCT02731638)
- Testing
- Intrastromal voriconazole, Natamycin
- Where
- 2 sites in United States, India
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Treatment of Early Pulmonary Infections With P. Aeruginosa in Cystic Fibrosis Patients
Randomized, Controlled Study of CF Patients Between 3 Months and Less Than 7 Years
This study investigated the efficacy of inhaled TOBI treatment for early infections of P. aeruginosa in paediatric patients with cystic fibrosis.
- Trial name
- EARLY (NCT01082367)
- Testing
- TOBI
- Where
- 19 sites in Canada, Egypt and 8 more
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
Sinusitis
The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusitis When Used With Antibiotics (Study P04824AM3)
The purpose of this study is to evaluate the efficacy and safety of Nasonex® (mometasone furoate nasal spray), when used together with an antibiotic, for the relief of symptoms associated with acute bacterial sinusitis.
- Trial name
- NCT00423176
- Testing
- MFNS and antibiotic
- Volunteers
- 237 people
- Sponsor
- Organon and Co
Bacterial Recovery of Skin Flora Post-Product Application
In Vivo Patient Preoperative Skin Prep Persistence
The objective of the study is to demonstrate persistence of the CHG/IPA Prep on skin flora of the abdominal and inguinal regions of human subjects.
- Trial name
- NCT02447497
- Testing
- 3M CHG/IPA Surgical Skin Preparation - Abdominal Region, Normal Saline - Abdominal Region, 3M CHG/IPA Surgical Skin Preparation - Inguinal Region
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Skin and Soft Tissue Infections, Abscess
The Effect of Irrisept for Irrigation of Skin and Soft Tissue Infections (Irrisept USF Study)
The purpose of this study was to determine whether Irrisept can effectively prevent the progression of skin and soft tissue infections (SSTIs) as compared to treatment by the current Standard of Care.
- Trial name
- NCT01076049
- Testing
- Standard of Care (SoC), Irrisept Delivery System
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Irrimax Corporation
Pulmonary Sarcoidosis, Lung Function
Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis
Sarcoidosis is a granulomatous disease for which the molecular and immunologic association with mycobacteria continues to strengthen.
- Trial name
- CLEAR Lung (NCT01169038)
- Testing
- levaquin; ethambutol; rifampin and azithromycin.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Bacterial Resistance
Bacterial Resistance in Patients Receiving Post-Intravitreal Injection Antibiotics
1. Background: Over 1 million intravitreal injections are performed annually in the United States. The most devastating complication related to these injections is endophthalmitis, with an incidence of 0.02 - 0.1% per injection.
- Trial name
- NCT02223338
- Testing
- Ciprofloxacin, Standard Aseptic Technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Loma Linda University
Erythema Chronicum Migrans
Duration of Antibiotic Treatment of Erythema Migrans
The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.
- Trial name
- NCT00910715
- Testing
- doxycycline
- Where
- Slovenia
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana