Clinical trials: Antibiotic
Aggressive Periodontitis
Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis
The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive…
- Trial name
- NCT02125812
- Testing
- scaling and systemic moxifloxacin, scaling and root planing
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Facultad Nacional de Salud Publica
Sepsis
Evaluation of Usage Patterns and Outcomes in Patients Receiving Ceftolozane/Tazobactan (C/T) in Brazilian Hospitals
Ceftolozane/Tazobactan (C/T) is a recent option to manage multidrug resistant gram-negative infections in hospital patients. Despite several randomized controlled trials describing safety and efficacy of C/T, real world evidence…
- Trial name
- NCT05267483
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Pneumonia, Tuberculosis, Pulmonary
The LalelaLung Study: Digital Stethoscope Clinical Evaluation
Pneumonia is the leading infectious cause of death in children under five years of age worldwide, and most of these deaths occur in low- and middle-income countries.
- Conditions
- Pneumonia, Tuberculosis, Pulmonary, Respiratory Tract Infections, Bronchiolitis
- Trial name
- LaLeLa (NCT07631377)
- Testing
- StethoMe AI-enabled digital stethoscope system, Standard IMCI assessment
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Adverse Reaction to Other Drugs and Medicines
Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention
For the prevention of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, norfloxacin 400mg per day is a standard regimen. Ciprofloxacin 750 mg per week is also known to be effective for prevention of SBP.
- Trial name
- NCT01542801
- Testing
- Norfloxacin, ciprofloxacin
- Where
- 7 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Korea University
Alveolar Ridge Augmentation, Bone Grafting
Antibiotic Prophylaxis Versus Placebo in Alveolar Bone Grafting: A Randomized Controlled Trial
Tooth extraction sites often require alveolar bone grafting to preserve ridge dimensions and improve conditions for future implant placement.
- Conditions
- Alveolar Ridge Augmentation, Bone Grafting, Antibiotic Prophylaxis
- Trial name
- ABXGRAFT (NCT07296302)
- Testing
- Amoxicillin 500 mg (prophylactic regimen)
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Agnaldo Rocha de Souza Junior
Drug Therapy
Safety Analysis of Antimicrobial Pharmacotherapy in Intensive Care Unit at Pediatric Hospital
Changes in the metabolic ability of cytochrome P-450 during child development can affect both bioavailability and elimination depending on the involvement of intestinal and hepatic metabolic processes.
- Trial name
- NCT04141657
- Testing
- Pharmacogenetic test
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Anna Vlasova
Joint Infection
Interest in Probabilistic Antibiotic Therapy With Broad-spectrum Beta-lactams in Orthopedic Surgery
The management of Joint Infections (JIs) requires a medical-surgical team which includes rheumatologists, infectious disease specialists, orthopedists as well as microbiologists.
- Trial name
- Prob-ATB (NCT06191601)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Clostridium Difficile Infection, Prophylaxis
Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics
The purpose of this study is to determine if oral vancomycin used as primary Clostridium difficile prophylaxis can reduce the incidence of this infection in high-risk patients.
- Conditions
- Clostridium Difficile Infection, Prophylaxis, Vancomycin
- Trial name
- NCT02951702
- Testing
- Vancomycin Oral
- Volunteers
- 51 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Infections, Human Cathelicidin Antimicrobial Peptide (hCAP-18)
Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Trial name
- NCT01758081
- Testing
- vitamin D3, omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 25,874 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Nosocomial Infections
Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation
Nosocomial infection with antibiotic-resistant strains is a major threat to critical care medicine. Selective decontamination of the digestive tract (SDD) is one of the strategies to reduce ventilator associated pneumonia and…
- Trial name
- LFasSDD (NCT01535170)
- Testing
- bovine Lactoferrin
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- China Medical University Hospital
Osteomyelitis of Jaw
Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis
The goal of this clinical trial is compare the efficacy of oral and IV antibiotics in the treatment of orofacial osteomyelitis. The main question it aims to answer is: Are oral antibiotics as effective as IV antibiotics in the…
- Trial name
- NCT05867654
- Testing
- Amoxicillin-clavulanate 875mg/125mg q12hrs, oral clindamycin 300mg q6hrs, Levofloxacin 750mg QID
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Louisville
Clostridium Difficile
Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain
The aim of this study was to analyze whether the use of the LP299v strain reduces the risk of Clostridium difficile infection (CDI) among patients receiving antibiotics and hospitalized in the nephrology and transplantation ward.
- Trial name
- NCT03368105
- Testing
- Prevention of C. difficile infections using LP299v strain
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Infection
Antibiotic Prophylaxis in Total Knee Prosthesis
Knee prosthesis infection is a severe complication. The use of a tourniquet during surgery impairs the efficacy of the antibiotic prophylaxis.
- Trial name
- NCT00497341
- Testing
- cefuroxime
- Where
- Spain
- Volunteers
- 1,332 people
- Sponsor
- Hospital Clinic of Barcelona
Sepsis
Beta-Lactam InfusioN Group Study
The purpose of this study is to find out whether continuous infusion of beta-lactam antibiotics or intermittent infusion or beta-lactam antibiotics, offers more health advantages to patients or if there is no difference.
- Trial name
- BLING III (NCT03213990)
- Testing
- Continuous infusion, Intermittent infusion
- Where
- 103 sites in Australia, Belgium and 5 more
- Volunteers
- 7,203 people
- Sponsor
- The George Institute
Antibiotic Prescribing Audit and Feedback
Providing Antibiotic Prescribing Feedback to Primary Care Physicians: The Ontario Program To Improve AntiMicrobial USE
Antibiotic overuse occurs in multiple jurisdictions and is associated with rising rates of antimicrobial resistance. Mailing letters to the highest antibiotic prescribing physicians is a potentially effective method to optimize…
- Trial name
- OPTIMISE (NCT03776383)
- Testing
- Antibiotic use feedback letter
- Where
- Canada
- Volunteers
- 3,500 people
- Sponsor
- Ontario Agency for Health Protection and Promotion
High Caries Risk Patients, Antimicrobial Effect
Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfaction to taste will also be tested.
- Conditions
- High Caries Risk Patients, Antimicrobial Effect, Salivary pH, Patient Satisfaction to Taste
- Trial name
- NCT03773094
- Testing
- Guava leaves extract, Chlorhexidine
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infection of Cesarian Section Wound Following Delivery
Antibiotic Prophylaxis for Elective Cesarean Section
A randomized controlled study comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.
- Trial name
- TOAPFECSACT (NCT02177994)
- Testing
- ceftriaxone 1gm for intravenous infusion
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Ain Shams Maternity Hospital
Pancreatic Cancer
Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab, following chemotherapy for the treatment of surgically resectable pancreatic cancer.
- Trial name
- NCT05462496
- Testing
- Biopsy, FOLFIRINOX, Ciprofloxacin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Myeloid Leukemia
Evaluation of Infective Risk, Efficacy of Bacterial Prophylaxis and Validation of Sepsis Scores NEWS (National Early Warning Score) and qSOFA (Quick Sequential Organ Failure Assessment) in Patient With Acute Myeloid Leukemia Treated With Intensive Chemotherapy
Evaluation of Infective Risk, Efficacy of Bacterial Prophylaxis and Validation of sepsis scores NEWS (National Early Warning Score) and qSOFA (Quick Sequential Organ Failure Assessment) in Patient With Acute Myeloid Leukemia…
- Trial name
- LAM-SEPSIS (NCT05249894)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Chronic Periodontitis
Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing
It is common practice to carry out the therapy of periodontal diseases in two phases. In a first, non-surgical phase, bacterial deposits on tooth surfaces (plaque and calculus) are removed using a cleaning method called "scaling…
- Trial name
- GAR (NCT02197260)
- Testing
- 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Geneva, Switzerland