Clinical trials: Antibiotic Resistance
Hepatobiliary Surgery, Prophylactic Antibiotics
Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings
To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
- Trial name
- PASH (NCT07620223)
- Testing
- Piperacillin-tazobactam
- Where
- China
- Volunteers
- 378 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Vaccine
Impact of Vaccines on Antimicrobial Microbial Resistance
Vaccination is a potentially critical component of efforts to arrest development and dissemination of antimicrobial resistance (AMR), though little is known about vaccination impact within low-income and middle-income countries.
- Trial name
- IVAR (NCT06450379)
- Where
- Malawi
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Malawi Liverpool Wellcome Programme
Infection, Bacterial, Antibiotic Resistant Infection
Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.
Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage.
- Conditions
- Infection, Bacterial, Antibiotic Resistant Infection, Diagnostic Self Evaluation, Meningitis, Bacterial
- Trial name
- NCT03252028
- Where
- 2 sites in Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fariba Nayeri
Peri-implant Mucositis, Oral Bacterial Infection
Bacterial Microbiota Characterization on Implant-supported PEEK and Titanium Provisional Abutments
The aim of this study is to determine the relative abundances of the different bacterial phyla and families in the microbiota present on the surface of PEEK implant-supported provisional abutments compared to titanium…
- Conditions
- Peri-implant Mucositis, Oral Bacterial Infection, Bacterial Resistance
- Trial name
- NCT03998865
- Testing
- Provisional abutment material
- Where
- Chile
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Michael Wendler Ernst
Bacterial Infections
Children's Antibiotic Resistant Infections in Low Income Countries
The main challenge of the ChARLI program is to assess the clinical burden of severe neonatal and childhood bacterial infections in low-income countries,in particular those caused by antibiotic resistant bacteria.
- Trial name
- ChARLI (NCT02074865)
- Testing
- biological samples
- Where
- Madagascar
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Healthy Adult
Effectiveness of AI-Assisted Antibiotic Prescribing
This randomized controlled trial aims to evaluate the impact of providing LLM access to physicians on antibiotic prescribing appropriateness, using a composite outcome instrument, the Antibiotic Prescribing Appropriateness Score…
- Trial name
- NCT07833293
- Testing
- ChatGPT
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
Sepsis
Procalcitonin to Guide Antibiotic Stop in Neurocritical Care Patients.
Antibiotic overconsumption has been considered as one of the major contributive factors of the emergence of multidrug resistant bacteria, a serious threat particularly in intensive care units.
- Trial name
- NCT03683693
- Testing
- Procalcitonin group
- Where
- Belgium
- Volunteers
- 132 people
- Sponsor
- General Hospital Groeninge
Gram-negative Bacterial Infections
Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream Isolates
This research is important because it allows for the determination of resistance rates to antibiotics that may not be frequently tested by the clinical microbiology laboratory at University of Pittsburgh Medical Center…
- Trial name
- NCT00394784
- Where
- United States
- Sponsor
- University of Pittsburgh
Febrile Neutropenia
Ambisome and Management of Culture-negative Neutropenic Fever Unresponsive to Antibiotics
Administration of a single high dose (10 mg/kg) of AmBisome® no later than 72 hours after ARNF onset followed by two 5 mg/kg doses on days 2 and 5 may provide sustained tissue levels of amphotericin B that are as mycologically…
- Trial name
- NCT00421187
- Testing
- Liposomal amphotericin B (AmBisome®)
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Gilead Sciences
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital
Methicillin-Resistant Staphylococcus Aureus, ESBL
Mastering Hospital Antimicrobial Resistance and Its Spread Into the Community-Healthcare Workers
Medical staff will be screened for MRSA and ESBL (including: doctors, nurses, nurse aids, physical therapists, dietitians, Janitors and other medical staff).
- Trial name
- MOSAR (NCT00773864)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Bacteriology
Dynamic of the Acquisition of Antibiotic Resistance in Integrons in Neonatology Newborns
Antibiotic resistance is a major public health issue as multiresistant bacteria (MRB) are increasing. Among the actions to control resistance, one is an interesting lead: to prevent the emergence of resistant bacteria by limiting…
- Trial name
- DAIR3N (NCT02434679)
- Where
- 5 sites in France
- Volunteers
- 278 people
- Sponsor
- University Hospital, Limoges
Gram-Negative Bacterial Infections
Feasibility Studies to Inform Novel Proposals to Avert Community-Based Antimicrobial Resistance Spread
There are many bacteria that naturally live in our gut and are essential for good health. These bacteria have a variety of helpful functions, such as aiding digestion, synthesizing vitamins, repressing the growth of harmful…
- Trial name
- NCT02666274
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
MRSA, VRE
Benefits of Universal Glove and Gowning
This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: Decrease the chance of patients getting…
- Trial name
- BUGG (NCT01318213)
- Where
- United States
- Volunteers
- 19,856 people
- Sponsor
- University of Maryland, Baltimore
Quality Improvement, Feedback
British Columbia Prescriber Feedback Program - Antimicrobial Resistance
The goal of this study is to evaluate an educational intervention that aims to reduce the number of unnecessary antibiotics prescribed by family physicians and nurse practitioners in British Columbia, Canada.
- Conditions
- Quality Improvement, Feedback, Prescribing, Antibiotics
- Trial name
- NCT07431190
- Testing
- Prescribing portrait audit and feedback
- Where
- Canada
- Volunteers
- 7,626 people
- Sponsor
- University of British Columbia
Multi-antibiotic Resistance
Fecal Transplant for MDR Pathogen Decolonization
This is a proof-of-principle research study designed to determine whether fecal microbiota transplantation (FMT) can eliminate highly drug-resistant bacteria from the intestinal tract of renal transplant patients.
- Trial name
- NCT02906774
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Resistance Bacterial
T2Resistance - Detection of Resistance Related Genes
The purpose of this study is to evaluate the safety and effectiveness of the T2Resistance Panel by validating clinical performance in three study arms: 1.
- Trial name
- NCT05231187
- Testing
- T2Resistance Panel
- Where
- 10 sites in United States
- Volunteers
- 1,566 people
- Sponsor
- T2 Biosystems
Colonization, Asymptomatic, Colistin
Impact of Reducing Colistin Use on Colistin Resistance in Humans and Poultry in Indonesia
Colistin (polymyxin E) is considered a last resort antimicrobial for treatment of infections with multidrug- resistant bacteria, classified by WHO as 'highest prioritized, critically important for human medicine'.
- Conditions
- Colonization, Asymptomatic, Colistin, Mcr-1, Antimicrobial Resistance
- Trial name
- COINCIDE (NCT05960084)
- Testing
- screening
- Where
- Indonesia
- Volunteers
- 803 people
- Sponsor
- Erasmus Medical Center
Bacteremia
Empirical Antibiotic and Outcome in Community-onset Bacteremia
Empirical antibiotic and outcome in Community-onset Bacteremia Caused by third generation cephalosporin resistant Enterobacteriaceae
- Trial name
- NCT03765749
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital