Clinical trials: Antibiotic Stewardship
COVID-19
Co-infection Management in COVID-19 Critically Ill
International guidelines suggest the administration of empirical broad-spectrum antibiotics for suspected bacterial co-infection in COVID-19 critically ill.
- Trial name
- NCT04382092
- Testing
- FilmArray Pneumonia
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diarrhea Infectious, Algorithms
The Utility and Feasibility of Accessible Diarrhea Etiology Prediction Tool (ADEPT) in an Informal Healthcare Setting
Diarrheal disease remains a leading cause of morbidity and mortality for children under 5 globally. Accepted best practice for managing diarrhea in the absence of blood or suspicion of cholera is rehydration, however in resource…
- Conditions
- Diarrhea Infectious, Algorithms, Decision Support Systems, Clinical, Clinical Decision-making
- Trial name
- NCT07538531
- Testing
- Diagnostic test: Accessible Diarrhea Etiology Prediction Tool (ADEPT)
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Daniel Leung
Child Health
Dynamic CDSA to Manage Sick Children in Rwanda
This study aims to reduce morbidity and mortality among children and mitigate antimicrobial resistance using a novel clinical decision support algorithm, enhanced with point-of-care technologies to help health workers in primary…
- Trial name
- DYNAMIC-RW (NCT05108831)
- Testing
- ePOCT+
- Where
- 39 sites in Rwanda
- Volunteers
- 85,212 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Ventilator Associated Pneumonia
Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care
Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health.
- Trial name
- ASPIC (NCT05124977)
- Testing
- Antimicrobial Stewardship, Standard management
- Where
- France
- Volunteers
- 590 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anti-Bacterial Agents
Carbapenems De-escalation as Antimicrobial Stewardship
Early de-escalation of carbapenems can reduce unnecessary use of carbaepenems compared with late de-escalation without compromised clinical outcomes
- Trial name
- NCT03114358
- Testing
- Early Carbapenem de-escalation
- Volunteers
- 104 people
- Sponsor
- Chiang Mai University
Drug Resistance, Microbial, Biomarkers
INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS
Urinary tract infections (UTI), mainly driven by Gram-negative bacteria (GNB) are a frequent cause of hospitalization and the second cause of antibiotic prescription after lower respiratory tract infections.
- Conditions
- Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents
- Trial name
- INVICTUS (NCT07675018)
- Testing
- Detection of integrons, Gold standard
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Limoges
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Infectious Disease, Pneumonia
FilmArray and Management of ICU Patients With Pneumonia in the Covid-19 Context
The research aims to determine the impact of a syndromic mutiplex PCR assay (FilmArray) on the management of patients hospitalized in ICU for severe respiratory disease.
- Conditions
- Infectious Disease, Pneumonia, Molecular Diagnosis, Covid-19
- Trial name
- FAP-REA (NCT04453540)
- Testing
- FilmArray PCR on respiratory samples
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
Antibiotics
Building a Novel Antibiotic Stewardship Intervention for Nursing Homes
The OASIS Collaborative is an organizational intervention aimed at reducing unnecessary antibiotic use in skilled nursing facilities.
- Trial name
- OASIS (NCT02874872)
- Testing
- OASIS Collaborative
- Volunteers
- 2,942 people
- Sponsor
- University of Wisconsin, Madison
Otitis Media, Antimicrobial Stewardship
Digital Otoscopy Versus Standard Otoscopy on the Diagnosis and Treatment of Otitis Media in Young Children
Randomized controlled trial involving 4 pediatric primary care practices in Massachusetts. Practices will be stratified by their OM diagnosis and treatment rate, with two practices randomly assigned to the intervention arm and…
- Trial name
- Wispr 2 (NCT07328555)
- Testing
- Device: Digital Otoscope
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston Children's Hospital
Acute Respiratory Infection
ASPIRE I: Supporting Antibiotic Stewardship in Primary Care Via POCT
The ASPIRE study is an uncontrolled observational feasibility study, and a collaboration between the University of South Wales and Cwm Taf Morgannwg University Health Board (CTMUHB).
- Trial name
- ASPIRE I (NCT06912022)
- Testing
- FebriDx Device
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of South Wales
Skin and Soft Tissue (SST) Infection
INSPIRE Trial for Skin and Soft Tissue Infections
The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized…
- Trial name
- NCT05423756
- Testing
- Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection
- Where
- 102 sites in United States
- Volunteers
- 118,562 people
- Sponsor
- Harvard Pilgrim Health Care
Nosocomial Infection, Sepsis
Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model
Antimicrobial agents are frequently used empirically and include therapy for both Gram-positive and Gram-negative bacteria. In Brazil, multidrug-resistant Gram-negative pathogens are the cause of most nosocomial infections in…
- Trial name
- NCT05312034
- Testing
- Implementation of the predictive model for an antimicrobial management program
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Hematologic Malignancy, Febrile Neutropenia
Early Neutropenic Fever De-escalation of Antibiotics Study
This is a randomized, open label clinical trial among individuals with hematologic conditions. The trial aims to evaluate the safety and clinical outcomes of de-escalating antibiotic therapy among stable individuals diagnosed…
- Conditions
- Hematologic Malignancy, Febrile Neutropenia, Antibiotic Stewardship
- Trial name
- END (NCT06278896)
- Testing
- Cessation of antibiotics
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Neutropenic Fever
Antibiotic Stewardship in Suspected Neutropenic Fever (ASTERIC Trial)
Executive Summary Background: Neutropenic Fever (NF), or febrile neutropenia, occurs in patients with early stage and metastatic solid tumours, non-leukaemic haematological cancers and acute leukaemia.
- Trial name
- NCT06794320
- Testing
- NF Protocol, ASTERIC protocol
- Where
- Hong Kong
- Volunteers
- 648 people
- Sponsor
- The University of Hong Kong
Blood Culture Rates, Antibiotic Stewardship
BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches
This study will compare two strategies that target distinct determinants of blood culture overuse in an exploratory, hybrid, pilot trial in 8 PICUs.
- Conditions
- Blood Culture Rates, Antibiotic Stewardship, Implementation Science
- Trial name
- LIBRA (NCT06187662)
- Testing
- Checklist, Targeted Messaging
- Where
- 8 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pneumonia
Procalcitonin Use in Pneumonia Patients in the Critical Care Setting
The goal of the study is to determine the impact of procalcitonin (PCT)-guided therapy on duration of antibiotic therapy in critical care unit (CCU) patients with suspected pneumonia at Mayo Clinic Health System Eau Claire.
- Trial name
- NCT01788488
- Testing
- Use of procalcitonin as biomarker to guide therapy
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Beta Lactam Allergy, Hematologic Malignancy
Allergy Delabeling in Antibiotic Stewardship - Intervention
The overall goal of the RENEW-IN intervention is to assess the impact of a BL allergy delabeling intervention on antibiotic use and clinical outcomes in patients with a hematologic malignancy.
- Trial name
- RENEW-IN (NCT07133074)
- Testing
- RENEW-IN Algorithm for assessment of a beta-lactam intervention, EMR Review
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Clostridium Difficile Infection, Health Care Associated Infection
Natural History of Clostridioides Difficile Infection
Aim: To investigate if host factors, such as composition and diversity of intestinal microbiota and/or genetic determinants, are associated with a higher risk of recurrence of Clostridioides difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, Health Care Associated Infection, Nosocomial Infection
- Trial name
- NCT04801862
- Where
- 15 sites in Spain
- Volunteers
- 750 people
- Sponsor
- Hospital Universitario de Valme