Clinical trials: Antibiotic Usage
Acute Respiratory Infections
C Reactive Protein (CRP) Intervention to Reduce Inappropriate Antibiotic Prescriptions in the Primary Healthcare Setting
Many studies have showed that rapid point-of-care (POC) c-reactive protein (CRP) test can reduce inappropriate use of antibiotic at primary health care level.
- Trial name
- CRP (NCT01918579)
- Testing
- Patients will be tested by rapid POC CRP test
- Where
- Vietnam
- Volunteers
- 2,037 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Resistance Bacterial, Increased Drug Resistance
Decreasing Irrational Antimicrobial Use in Bangladesh: A Digital Intervention Program
We developed 'SmartAMR', a digital pharmacy system featuring real-time records, symptom checks, telemedicine, counselling, and medication reminders.
- Conditions
- Resistance Bacterial, Increased Drug Resistance, Drug Resistance, Microbial
- Trial name
- SmartAMR (NCT06313619)
- Testing
- SmartAMR
- Where
- Bangladesh
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Non Muscle Invasive Bladder Cancer
A Prospective Open Label Comparative Dose Ranging Study Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC)
This study is a prospective randomized open labeled dose ranging comparative study. Twenty four (24) patients with NMIBC who meet the inclusion/exclusion criteria will be recruited for the study following the initial diagnostic…
- Trial name
- NMIBC TURBT HG (NCT01799499)
- Testing
- TC-3 hydrogel
- Where
- Israel
- Sponsor
- UroGen Pharma Ltd.
Medication Adherence
Perspectives on Prophylactic Antibiotic Use in Dermatologic Surgery
This is a prospective, multi-center observational survey study to uncover how antibiotic differences can influence utilization decisions.
- Trial name
- NCT04150523
- Testing
- Survey
- Where
- 8 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Antibiotic Side Effect, Behavioral Changes
Improving Antibiotic Use in Urgent Care Facilities
This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare.
- Trial name
- SCORE_UC (NCT03932708)
- Testing
- CDC Core Elements of Outpatient Stewardship
- Where
- United States
- Volunteers
- 700,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Antibiotic Resistance Prevention
Effect of a Health Education Program on Teachers' Antibiotic Use Practices
Antibiotic resistance is a growing public health problem caused in part by inappropriate use of antibiotics. Teachers play an important role in shaping health knowledge and behaviors within schools and communities.
- Trial name
- NCT07371507
- Testing
- Behavioral
- Where
- Iraq
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Ear Infection Bacterial, Surgical Site Infection
Use of Preoperative and Postoperative Antimicrobial Treatment
In this study, patients undergoing ear surgery (cochlear implantation, stapedotomy, tympanoplasty) will be randomized to one of two antibiotic treatment groups.
- Conditions
- Ear Infection Bacterial, Surgical Site Infection, Antibiotic Side Effect
- Trial name
- NCT04707092
- Testing
- Antibiotic
- Where
- Canada
- Volunteers
- 304 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anti-Bacterial Agents, Respiratory Tract Infections
Improving Antimicrobial-Prescribing in Emergency Departments
Antimicrobial resistance is one of today's most urgent public health problems. One of the most important strategies to slow the spread of antimicrobial resistance is the promotion of judicious antimicrobial use.
- Trial name
- NCT03349567
- Testing
- Audit-and-feedback
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Periodontitis, Surgery
Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether the use of a systemic antimicrobial (metronidazole) as an adjunct to periodontal surgery provides additional clinical and microbiological beneficial effects compared to…
- Trial name
- NCT03880448
- Testing
- Metronidazole, periodontal surgery
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Urinary Tract Infection, Fever
Treatment's Duration of Acute Uncomplicated Pyelonephritis
The purpose of this study is to compare the efficacy of 5 days versus 10 days treatment duration in uncomplicated acute pyelonephritis.
- Trial name
- DTP (NCT00873626)
- Testing
- levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
- Where
- 2 sites in France
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nosocomial Pneumonia (NP), Ventilator-associated Pneumonia (VAP)
A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
The purpose of the study is to evaluate the effects of Ceftazidime-Avibactam compared to Meropenem for treating hospitalized adults with nosocomial pneumonia including ventilator-associated pneumonia
- Trial name
- NCT01808092
- Testing
- ceftazidim-avibactam (CAZ-AVI, experimental product), meropenem (active comparator)
- Where
- 123 sites in Argentina, Brazil and 24 more
- Volunteers
- 969 people
- Sponsor
- Pfizer
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Surgical Site Infection
Surgical Site Infection After Episiotomy Repair Related to Routine Use of Antibiotic Prophylaxis in Low-Risk Population
Bacterial infections occurring during labor, childbirth, and the puerperium may be associated with considerable maternal and perinatal morbidity and mortality.
- Trial name
- NCT06154720
- Testing
- Antibiotics
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries
The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or…
- Trial name
- NCT00612469
- Testing
- Sodium Fluoride, vancomycin hydrochloride, chlorhexidine digluconate
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Increased Drug Resistance, Infection Resistant to Quinolones and Fluoroquinolones
Change in Ocular Flora Resistance From Repeated Topical Antibiotic Use
The purpose of this study is to determine if antibiotic resistance of the ocular surface flora to the 4th generation fluoroquinolones will increase after repeated use of topical antibiotics for three days post intravitreal…
- Trial name
- NCT01181713
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Community-acquired Pneumonia
Use of a Rapid Diagnostic Test for Antibiotic De-escalation in Severe Community Acquired Pneumonia
The purpose of this study is to conduct an open-label step-wedge pilot clinical trial to compare an antibiotic strategy based on routine use of a novel rapid diagnostic test to usual care in critically ill adults with severe…
- Trial name
- BioFire (NCT04781829)
- Testing
- BioFire Pneumonia Panel
- Sponsor
- Northwestern University
Antibiotic Stewardship, Overactive Bladder
Antibiotic Usage Prior to OnabotulinumtoxinA Injection
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is…
- Conditions
- Antibiotic Stewardship, Overactive Bladder, Onabotulinumtoxin A, UTI
- Trial name
- NCT04754737
- Testing
- No antibiotic, Prophylactic antibiotic, cystoscopic injection of onabotulinumtoxinA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Use of Aaerosol Combined With Intravenous Antibiotics for the Treatment of Multidrug Resistant GNB Pneumonia
To investigate use of aerosol combined with intravenous antibiotics for the treat of multi-drug resistance gram negative bacterias diagnosed ventilator-associated pneumonia in intensive care unit in a hospital.
- Trial name
- ACAMP (NCT03921645)
- Testing
- aerosol antibiotics
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital