Clinical trials: Antibiotic Usage
Urinary Tract Infections
Application of a Prediction Model for Directing Antibiotic Use in the Treatment of Urinary Tract Infection in an Ambulatory Setting
Urinary tract infection (UTI) is when bacteria enter the urinary system and cause an infection. UTIs cause symptoms including burning when peeing, a feeling of an increased urge to pee, and cloudy or strong-smelling urine.
- Trial name
- NCT06976125
- Testing
- Decision Aid-prediction model
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University Hospitals Cleveland Medical Center
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Antibiotic Use, Carriage of Antibiotic Resistant Pathogens
Israeli Judicious Antibiotic Prescription Study
This study aims to implement judicious antibiotic prescription habits to primary care pediatricians using a multifacet educational intervention and assess two main outcomes: 1) Direct outcome - prescription rates of the…
- Trial name
- IJAP (NCT01187758)
- Testing
- Workshops and focus group meetings
- Volunteers
- 5,700 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Bacterial Infections
Clinical and Economic Impact of Interventions by a Clinical Pharmacist on Antibiotic Use on Surgical Wards
The purpose of this study is to establish the impact of a pharmacist's recommendations regarding choice, dosing and duration of antibiotic therapy on quality and cost of antibiotic treatment on surgical wards.
- Trial name
- NCT00431483
- Testing
- pharmaceutical consulting
- Where
- Germany
- Volunteers
- 779 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Meningitis
Daptomycin in Pediatric Patients With Bacterial Meningitis
5 Children > 3months and < 16 years with Gram-positive meningitis will receive a single dose of daptomycin 24 hours after the first dose of ceftriaxone.
- Trial name
- NCT01522105
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Late-Onset Neonatal Sepsis
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- EMERAUDE (NCT03299751)
- Testing
- Diagnostic performances of biomarkers combination
- Where
- 2 sites in France
- Volunteers
- 233 people
- Sponsor
- Hospices Civils de Lyon
Rhinosinusitis
Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study
Chronic rhinosinusitis is a pervasive and costly disease. Recent estimates describe over 20 million Americans suffering from this diagnosis at a cost of over $4.3 billion per year.
- Trial name
- NCT00669799
- Testing
- gentamyacin
- Where
- United States
- Sponsor
- University of South Florida
Acute Febrile Illness, Use of Antimicrobial Agents
Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
In Health Posts of rural areas operated by the Government of Nepal, there are limitations of tests to differentiate between bacterial and viral infections.
- Conditions
- Acute Febrile Illness, Use of Antimicrobial Agents, C-reactive Protein Level
- Trial name
- CREATIB (NCT05292508)
- Testing
- C-reactive Protein Rapid Diagnostic Test
- Where
- Nepal
- Volunteers
- 924 people
- Sponsor
- Patan Academy of Health Sciences
Gastric Varices, Cirrhosis
Efficiency and Safety of Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
The purpose of the study is to assess the efficiency and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
- Trial name
- NCT02693951
- Testing
- Cefotiam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Endocarditis, Bacterial, Opioid-use Disorder
Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis
Hospitalizations for severe infections associated with opioid use disorder (OUD), such as infective endocarditis (IE), have doubled in the US over the past decade and are frequently prolonged and resource-intensive.
- Conditions
- Endocarditis, Bacterial, Opioid-use Disorder, Buprenorphine, Outpatient Parenteral Antibiotic Therapy
- Trial name
- CATS-CARE (NCT03048643)
- Testing
- Outpatient parenteral antibiotic therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Laura Fanucchi
Surgical Site Infection in Obese Women Undergoing C-section
Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery
The purpose of this study is to evaluate if preoperative antibiotics, followed by 48 hour course of broad spectrum antibiotics prevents wound infection complications in patients that are obese who undergo cesarean section.
- Trial name
- SSI (NCT01194115)
- Testing
- cephalexin & metronidazole
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- University of Cincinnati
Acute Appendicitis, Perforated Gastroduodenal Ulcer
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
Aim of prospective randomized a placebo controlled study is to prove that in case of acute surgical procedure due to appendicitis, ileus of small bowel and perforation of small bowel and stomach appropriately administered…
- Conditions
- Acute Appendicitis, Perforated Gastroduodenal Ulcer, Small Bowel Obstruction
- Trial name
- NCT01524081
- Testing
- Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole
- Where
- Czechia
- Volunteers
- 187 people
- Sponsor
- The Faculty Hospital Na Bulovce
MRSA, VRE
Benefits of Universal Glove and Gowning
This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: Decrease the chance of patients getting…
- Trial name
- BUGG (NCT01318213)
- Where
- United States
- Volunteers
- 19,856 people
- Sponsor
- University of Maryland, Baltimore
Pneumonia, Bacterial
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin fosfomycin inhalation system (AFIS) versus aerosolized placebo to treat Gram-negative pneumonia in mechanically ventilated patients receiving IV…
- Trial name
- IASIS (NCT01969799)
- Testing
- Amikacin fosfomycin inhalation solution
- Where
- 41 sites in United States, France and 5 more
- Volunteers
- 143 people
- Sponsor
- Cardeas Pharma
Relationship of Carbapenem Use to Carbapenem Resistant Gram-negative Bacteria
Predictors of Rates of Resistant Gram-Negative Bacteria
Antibiotic resistance in gram-negative bacteria continues to increase in US hospitals. This comes at a time when there are few new drugs in development that are active for these resistant organisms.
- Trial name
- NCT01075009
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Virginia Commonwealth University
Chronic Periodontitis
STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features.
- Trial name
- NCT01906450
- Testing
- Scaling and root planing plus Azithromycin
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Dengue, Chikungunya
Impact of Differential and Systematic Diagnosis of Dengue, Chikungunya and Malaria on Patient Management and Antibiotic Use in West Africa
The differential and systematic diagnosis of malaria, dengue and chikungunya in patients with fever (≥38.5°C) of undetermined etiology would allow the identification of infection by these pathogens and thus limit the…
- Conditions
- Dengue, Chikungunya, Malaria
- Trial name
- NCT06257810
- Testing
- VIDAS® Dengue Antigen NS1, VIDAS® Anti-Dengue IgM, VIDAS® Anti-Dengue IgG, VIDAS® Anti-Chikungunya IgM and VIDAS® Anti-Chikungunya IgG, Standard of care practices
- Where
- 3 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 804 people
- Sponsor
- BioMérieux
Medication Adherence, Antibiotic Resistance, Microbial
7-VINCut Antibiotic Stewardship Intervention to Decrease Duration of Antibiotic Treatment and Carbapenem Use in Surgery
Antimicrobial resistance (AMR) is one of the top ten public health threats facing humanity. The misuse and overuse of antibiotics has been identified as a major factor in the development of drug-resistant pathogens, and 30% of…
- Conditions
- Medication Adherence, Antibiotic Resistance, Microbial, Medication Errors and Other Product Use Errors and Issues
- Trial name
- 7_VINCUT (NCT05813821)
- Testing
- Antimicrobial stewardship in surgery
- Where
- Spain
- Volunteers
- 32,499 people
- Sponsor
- Hospital de Granollers
Covid19, Pneumonia
Use of a Respiratory Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Patients With Severe Confirmed COVID-19 Pneumonia
The novel coronavirus SARS-CoV-2 (COVID-19) is an emerging respiratory virus that causes pneumonia. WHO data reported admission to the intensive care unit (ICU) for 6% of patients, with a mortality rate reaching 45%.
- Trial name
- MultiCov (NCT04334850)
- Testing
- Combined use of a respiratory broad panel multiplex PCR and procalcitonin, Usual antibiotic treatment
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Skin Diseases, Infectious
Utility of Trimethoprim-sulfamethoxazole Use in Skin Abscess Management
The purpose of this study is to determine if antibiotics are required in the management of skin abscess following incision and drainage.
- Trial name
- NCT00679302
- Testing
- Trimethoprim-sulfamethoxazole
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- St. Louis University