Clinical trials: Antibiotic Usage
Malaria, Pneumonia
Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs
This study is to assess the value of incorporating a malaria RDT based strategy in HMM. The primary activity of the study wil be a two armed cluster randomised trial in two study sites in Uganda, one in Ghana and one in Burkina…
- Trial name
- NCT00720811
- Testing
- Artemether-lumefantrine combination, amoxycillin, paracetamol
- Where
- 4 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 6,456 people
- Sponsor
- Mbarara University of Science and Technology
Healthcare Associated Infection
Copper Use as Protection Against Antimicrobial Resistance in the ICU
CUPRIC is an investigator initiated and conducted, prospective, quasi-experimental study to determine whether the combined use of copper-alloyed objects plus copper-enriched textiles reduce the burden of MDRO colonization and…
- Trial name
- CUPRIC (NCT04873557)
- Testing
- Copper-based surfaces plus copper-enriched linen
- Where
- Chile
- Volunteers
- 168 people
- Sponsor
- Universidad del Desarrollo
Diarrhea, Clostridium Difficile
Efficacy and Safety of Lactobacillus Acidophilus/Rhamnosus Combination for the Prevention of Antibiotic-associated Diarrhea in the Elderly
The purpose of this study is to determine whether Lactobacillus acidophilus/rhamnosus complex is effective in the prevention of antibiotic-associated diarrhea (AAD) in the elderly.
- Trial name
- NCT01048567
- Testing
- Lactobacillus acidophilus/rhamnosus
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Vancouver Island Health Authority
Bacterial Infections
PROcalcitonin Reduce Antibiotic Treatments in Acute-Ill Patients (PRORATA)
The study is a prospective, randomized, controlled intervention trial conducted in 9 centers, comparing a conventional strategy versus a PCT-guided strategy to start or to discontinue antibiotics, in patients with suspected…
- Trial name
- PRORATA (NCT00472667)
- Testing
- Procalcitonin guided strategy
- Where
- France
- Volunteers
- 630 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Scrub Typhus
Clinical Effectiveness of Tigecycline for Scrub Typhus.
This multicenter, randomized, open-label clinical trial evaluated the efficacy and tolerability of intravenous tigecycline compared with oral doxycycline in adults hospitalized with scrub typhus.
- Trial name
- NCT07513103
- Testing
- doxycycline, Tigecycline (Tygacil)
- Where
- 3 sites in South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jin Soo Lee
Urinary Tract Infection, Antibiotic Use
Optimizing Antibiotic Use in Long Term Care
The purpose of this study was to determine if a multi-faceted intervention to implement diagnostic and therapeutic algorithms for management of suspected urinary infection in nursing home residents could reduce antibiotic…
- Trial name
- NCT00243360
- Testing
- diagnostic and treatment clinical algorithms
- Where
- Canada
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Acute Chest Syndrome, Sickle Cell Disease
Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome.
Many patients with Sickle Cell Disease (SCD) may develop Acute Chest Syndrome (ACS). ACS is usually caused by a Lower respiratory tract infection (LRTI) which may be caused by either a bacterium or a virus.
- Trial name
- Antibio_STA (NCT03919266)
- Testing
- Intervention: Combined use of a respiratory broad panel multiplex PCR and procalcitonin, Control: usual antibiotic treatment
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lower Extremity Fracture
Antibiotic Use & Open Fracture of the Lower Extremity
It is important to recognize the potential for renal injury and be cognizant of this during the management of complex trauma patients.
- Trial name
- NCT05267977
- Testing
- Cephalosporin 1St Generation, Aminoglycosides
- Sponsor
- Methodist Health System
Breastfeeding, Breastfeeding Education
Improved Child Nutrition and Development Through Social Transfers
The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Education, Breastfeeding Duration, Breastfeeding Continuation
- Trial name
- TENDER (NCT07569172)
- Testing
- Social Transfer
- Where
- Côte d’Ivoire
- Volunteers
- 1,040 people
- Sponsor
- Swiss Tropical & Public Health Institute
Critical Illness
Antibiotic Regimens Tailored by Clinical Pharmacist Suppored by Intensivist Enhanced Rational Use of Antibiotics
adding pharmaceutical services to patient care and changing the professional activity of pharmacists from drug-focused to patient-oriented care,in the current study, clinical pharmacists will be assigned to monitor…
- Trial name
- NCT04931914
- Testing
- Clinical pharmacy sharing in the patient care regimen
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- University of Alexandria
Ophthalmia Neonatorum
Prevalence of Conjunctivitis and Indentification of Risk Factors With and Without Prophylactic Antibiotic Treatment in Neonates
The French guidelines for the use of Rifamycine eye drops in delivery room to prevent neonatal conjunctivitis have been actualized.
- Trial name
- CRY-NOT (NCT03528915)
- Testing
- Rifamycine treatment, whithout Rifamycine treatment
- Where
- France
- Volunteers
- 881 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgery Complications, Surgery
SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol
This study aims to assess and improve the global outcomes following surgery. Every year approximately 313 million operations are performed, with 50 million people experiencing a complication and unfortunately 3.5 million people…
- Conditions
- Surgery Complications, Surgery, Global Surgery, Robotic
- Trial name
- SurgWeek-2 (NCT07785076)
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Catheter-Related Infections
AgION Catheter for Preventing Catheter-Related Bloodstream Infections
The investigators assessed if use of AgION-impregnated umbilical catheters can decrease the occurrence of catheter-related bloodstream infections (CRBSI) in preterm infants.
- Trial name
- NCT01564615
- Testing
- Umbilical catheterization (AgION ), Umbilical catheterization (ArgyleTM)
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of Florence
Urinary Tract Infection
Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI
In this study, patients with uncomplicated urinary infection are investigated. It is investigated if treatment of only symptoms of the uncomplicated urinary infection is as effective as treatment with antibiotics with respect to…
- Trial name
- NCT01488955
- Testing
- Ibuprofen, Fosfomycin-Trometamol
- Where
- 2 sites in Germany
- Volunteers
- 494 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Community-Acquired Pneumonia
Improved Use of Antibiotic Guidelines in Hospital Environment
The purpose of this study is to determine if the use of antibiotic guidelines and thus antibiotics can be improved through a description of possible barriers leading to tailored interventions.
- Trial name
- NCT00512772
- Where
- 2 sites in Belgium
- Volunteers
- 823 people
- Sponsor
- KU Leuven
Methicillin Resistant Staphylococcus Aureus
Antibiotics Use and Carriage of Methicillin-resistant Staphylococci in Community Patients
In this prospective, observational, multicentric open study, the investigators will compare the acquisition rates of methicillin-resistant staphylococci (coagulase-negative staphylococci and Staphylococcus aureus) nasal carriage…
- Trial name
- StaphMRG (NCT01489878)
- Where
- France
- Volunteers
- 571 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Tract Diseases
Impact of Pharmacist Led Multidisciplinary Deprescribing Strategy in Patients With Respiratory Tract Infections
This prospective, open-label, randomized controlled trial will evaluate the impact of a pharmacist-led multidisciplinary deprescribing strategy on azithromycin use in clinically stable adults aged 18-65 years with respiratory…
- Trial name
- RCT (NCT07849491)
- Testing
- Pharmacist-Led Azithromycin Deprescribing Intervention
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Xi'an Jiaotong University
Ventilator Associated Pneumonia ( VAP)
Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated Pneumonia
Assess the impact of a strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology on the early optimization of initial antibiotic therapy for ventilator-associated pneumonia (VAP)…
- Trial name
- SMART-VAP (NCT07403474)
- Testing
- strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Disease
Efficacy of Information System Regarding the Consumption of Antibiotics and Bacterial Resistance in Primary Care
France is a country strong consumer of antibiotics in Europe, specially in primary care. Outpatient antibiotic use represents around 90% of total antibiotic use and prescriptions come mainly from general practitioners.
- Trial name
- SICAR-Amb (NCT02816528)
- Testing
- Training program
- Volunteers
- 472 people
- Sponsor
- Central Hospital, Nancy, France
Mandible Fracture, Post-operative Antibiotics
The MANTRA Trial (MANdibular TRauma and Antibiotic Use)
1. FULL TITLE OF THE PROJECT Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use) 2.
- Trial name
- MANTRA (NCT05964140)
- Testing
- Different post-operative antibiotic regimens following surgical treatment of mandible fractures
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,841 people
- Sponsor
- East Lancashire Hospitals NHS Trust