Clinical trials: Antibiotic Usage
Chronic Periodontitis, Periodontal Bone Loss
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
- Conditions
- Chronic Periodontitis, Periodontal Bone Loss, Resistance Bacterial
- Trial name
- NCT03863249
- Testing
- SCALE AND ROOT PLANING, ADJUNTIVE ANTIBIOTICS, MICROBIAL SAMPLING
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- University of Valencia
Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles
Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
The purpose of this study is to study the effect of a commonly used antibiotic, doxycycline, on the production of ovarian hormones and menstrual cycles in women with Polycystic Ovarian Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles, Androgen Excess
- Trial name
- MI-PCOS (NCT01788215)
- Testing
- doxycycline, Sugar Pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Infection, Sepsis
KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill Patients
The study aims to compare the efficacy and safety of an absolute procalcitonin (PCT) value-guided antibiotic initiation protocol and a protocol using the kinetics of PCT (the difference between the actual and the previous day…
- Trial name
- KIPRUN (NCT07211620)
- Testing
- Kinetics, Absolute
- Where
- 2 sites in Hungary
- Volunteers
- 250 people
- Sponsor
- Semmelweis University
Pneumonia, Radiographic Lung Infiltrates
Use Of Procalcitonin Level For Guidance of The Treatment of Suspected Community Acquired Pneumonia
The purpose of the study is to learn if a blood test is helpful to the doctors in deciding whether you need antibiotic therapy for possible pneumonia.
- Trial name
- NCT00914550
- Testing
- Procalcitonin level, caregiver informed
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Winthrop University Hospital
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Antibiotics Causing Adverse Effects in Therapeutic Use
Role of Prophylactic Antibiotics in Preventing Pelvic Infection After Surgical Evacuation
To determine the role of antibiotic prophylaxis in the surgical management of miscarriage.
- Trial name
- NCT05040334
- Testing
- Group 1: Antibiotic receiving group
- Where
- Egypt
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Cairo University
Congenital Malformations
Maternal Use of Antibiotics and the Risk of Congenital Malformations
Antibiotics are widely used during pregnancy to prevent or treat infections, yet concerns remain regarding their fetal safety. Drawing on data from spontaneous reporting databases and cohort studies, this study aims to explore…
- Trial name
- NCT06770465
- Testing
- Different categories of antibiotics
- Where
- China
- Volunteers
- 850,000 people
- Sponsor
- West China Hospital
Fever Without Source
Impact of a PCT(Procalcitonin) Rapid Test -Based Approach on ATB (Antibiotics) Use in Children With Fever Without Source
Because a newly available point-of-care test may have real interest especially for children in the Emergency Department (ED) setting, by limiting painful and stressful venipunctures and decreasing the length of stay in the ED…
- Trial name
- DIAFEVER (NCT03607162)
- Testing
- DIAFEVER algorithm
- Where
- 26 sites in France, Switzerland
- Volunteers
- 4,928 people
- Sponsor
- Nantes University Hospital
Antimicrobial Effect
An Evaluation of the Efficacy of HEXI-PREP by Clinell Wipes
This study evaluates the antimicrobial properties of HEXI-PREP by Clinell compared to both a negative and a positive control product.
- Trial name
- NCT03417661
- Testing
- HEXI-PREP By Clinell Wipes, Chloraprep
- Where
- United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Gama Healthcare Ltd.
Antimicrobial Stewardship, Cardiovascular Surgeries
Evaluation of the Potential Impact of Computerized Antimicrobial Stewardship
This trial is an open-label, two-arm, cluster-randomized, controlled trial with cardiovascular surgical teams as the unit of randomization.
- Conditions
- Antimicrobial Stewardship, Cardiovascular Surgeries, Computerized Decision Support System, Coronary Artery Disease
- Trial name
- EPIC (NCT04328090)
- Testing
- Computer based Antimicrobial stewardship (AMS) intervention system
- Where
- China
- Volunteers
- 2,473 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Respiratory Tract Infection
The Procalcitonin Guided Antibiotics in Respiratory Infections in General Practice
Antimicrobial resistance rates have reached alarming levels and the Worlds Health Organisation (WHO) states it constitutes a serious public health concern by threatening one of the most effective and mortality lowering…
- Trial name
- PARI (NCT04216277)
- Testing
- Procalcitonin
- Where
- 6 sites in Denmark
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Adults, Acute Respiratory Tract Infection
The C-reactive Protein (CRP) Point of Care Testing (POCT) Implementation to Adult Patients Presenting With Symptoms of the Acute Respiratory Tract Infection (ARTI) in Eight Primary Health Care (PHC) in Jakarta.
Antimicrobial resistance (AMR) has emerged as one of the most pressing global health challenges of the 21st century, particularly Indonesia is projected to be among the five nations globally with the highest percentage increase…
- Conditions
- Adults, Acute Respiratory Tract Infection, Antibiotic Prescriptions
- Trial name
- INA IMPACT-RTI (NCT07717372)
- Testing
- Implementation group
- Where
- 8 sites in Indonesia
- Volunteers
- 2,544 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Infectious Disease of Digestive Tract
The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on a ventilator.
- Trial name
- NCT01551186
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Washington University School of Medicine
Antimicrobial Resistance
Efficacy and Cost-effectiveness of Hospital Antimicrobial Stewardship Programs
The main objective of the project is to evaluate the efficiency and cost-effectiveness of different strategies aiming at optimizing antibiotic prescribing in hospitals.
- Trial name
- CEFECA (NCT02814877)
- Testing
- promotion of appropriate use of antibiotics in hospital
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgical Site Infection, Skin Cancer
Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision
This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision.
- Conditions
- Surgical Site Infection, Skin Cancer, Wound Healing
- Trial name
- NCT07844681
- Testing
- Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Pilot Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454960)
- Testing
- Clinical Decision Support: Accountable Justification, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Southern California
Febrile Neutropenia
Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia
In this study the investigators aim to test if a procalcitonin (PCT) - guided strategy allows to reduce the antibiotic use in patients with febrile neutropenia hospitalized in a Brazilian tertiary university hospital, causing no…
- Trial name
- NCT00928291
- Testing
- procalcitonin, antibiotic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Antibiotic, Oral Health Care
Parental Views on Antibiotics in Dentistry
This study aims to assess parents' knowledge of antibiotic use and its relationship with their children's oral health.
- Conditions
- Antibiotic, Oral Health Care, Parents, Pediatric Dentistry
- Trial name
- NCT07112079
- Where
- Turkey (Türkiye)
- Volunteers
- 1,610 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Vaccine
Impact of Vaccines on Antimicrobial Microbial Resistance
Vaccination is a potentially critical component of efforts to arrest development and dissemination of antimicrobial resistance (AMR), though little is known about vaccination impact within low-income and middle-income countries.
- Trial name
- IVAR (NCT06450379)
- Where
- Malawi
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Malawi Liverpool Wellcome Programme