Clinical trials: Antibiotic Usage
Influenza
Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics
The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the…
- Trial name
- VAX-002 (NCT02154061)
- Testing
- IIV Flu Vaccine, Metronidazole, Neomycin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Cystic Fibrosis
Use of a Biofilm Antimicrobial Susceptibility Assay to Guide Antibiotic Therapy
The purpose of this study is to determine whether choosing antibiotics based on a biofilm antimicrobial susceptibility assay rather than a conventional planktonic antimicrobial susceptibility assay to treat CF patients with…
- Trial name
- NCT00786513
- Testing
- Conventional antimicrobial susceptibility testing, Biofilm antimicrobial susceptibility testing
- Where
- 5 sites in Canada
- Volunteers
- 134 people
- Sponsor
- The Hospital for Sick Children
Cholecystitis, Acute
Effectiveness of Empirical Antibiotic Use in Mild to Moderate Acute Inflammatory Gallbladder Disease
This clinical trial is an exploratory clinical trial that evaluates the necessity and effectiveness of empirical antibiotic use in mild and moderate acute inflammatory gallbladder diseases that require surgery, and the incidence…
- Trial name
- NCT05339282
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 370 people
- Sponsor
- Seoul St. Mary's Hospital
Cirrhosis, Sepsis
Cohort Study of Chronic Liver Disease Complicated by Sepsis
Study population: Patients with liver cirrhosis complicated by sepsis Observation indicators: Fluid resuscitation strategy, early dynamic indicators such as MAP Observation endpoint: 28-day all-cause mortality Study design…
- Trial name
- NCT07465003
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Urinary Tract Disease, Cystitis
Effect of Cranberry Extract on the Urinary System
In this study, we will try to emphasize the effects of using cranberry tablets, which is an alternative to antibiotic therapy, during uncomplicated urinary tract infections (only urinary tract, bladder and kidney infections did…
- Conditions
- Urinary Tract Disease, Cystitis, Antibiotic Reaction
- Trial name
- NCT05260554
- Testing
- Fosfomycin, Cranberry
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Kırklareli University
Lower Extremity Fracture
Antibiotic Use & Open Fracture of the Lower Extremity
It is important to recognize the potential for renal injury and be cognizant of this during the management of complex trauma patients.
- Trial name
- NCT05267977
- Testing
- Cephalosporin 1St Generation, Aminoglycosides
- Sponsor
- Methodist Health System
Infections
Antimicrobial De-escalation Strategy in Medical Patients
The purpose of this pilot study is to assess the impact of an antibiotic de-escalation strategy on the clinical outcomes (clinical cure or improvement) of medical patients related to the usage of of broad-spectrum antimicrobial…
- Trial name
- NCT01066013
- Testing
- Antimicrobial de-escalation strategy
- Volunteers
- 100 people
- Sponsor
- Fraser Health
Chorioamnionitis
Selective Use of Antibiotics in Neonates Born to Mothers With Suspected Chorioamnionitis
Retrospective Chart Review to determine the selective use of antibiotics in neonates born to mothers with suspected chorioamnionitis
- Trial name
- Chorio (NCT03576560)
- Testing
- Retrospective Chart Review
- Where
- United States
- Volunteers
- 768 people
- Sponsor
- Pediatrix
Snoring, Strep Throat
Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use
This study is designed to look at healthcare utilization following the removal of tonsils and adenoids in pediatric patients who are not given an antibiotic following surgery.
- Trial name
- NCT01561703
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Missouri-Columbia
Community Acquired Pneumonia (CAP), Sinusitis
Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care
The goal of this project is to reduce unnecessary antibiotic use for children with ARTIs (Acute Respiratory Tract Infections) by implementing "outpatient antibiotic stewardship" across the Children's Hospital of Philadelphia…
- Conditions
- Community Acquired Pneumonia (CAP), Sinusitis, Strep Pharyngitis, Acute Otitis Media (AOM)
- Trial name
- RAISIN (NCT07217002)
- Testing
- Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital of Philadelphia
Colitis, Ulcerative
Antibiotics for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease, whose cause is unknown. However, it is widely accepted that bacteria living in the large bowel are essential for the development of the disease.
- Trial name
- NCT00355602
- Testing
- Cefuroxime, Ciprofloxacin, Clarithromycin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Dundee
Escherichia Coli Infections, Klebsiella Infections
Study Evaluating Antibiotic Use in Reducing Vancomycin-Resistant Enterococci and ESBL Producing Escherichia Coli and Klebsiella Pneumoniae in Intensive Care
To determine whether the restriction of 3rd generation cephalosporins and carbapenems contribute to the reduction of intestinal colonization or infection with vancomycin-resistant enterococci (VRE) in a medical intensive care…
- Trial name
- NCT00167986
- Testing
- vancomycin-resistant enterococci and ESBL
- Where
- South Korea
- Volunteers
- 480 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healing Wound
Adjunctive Use of an Antibacterial Honey Dressing for Palatal Wound Healing After Harvesting a Free Gingival Graft
This case-control study will afford a more understanding of the clinically benefits that the antibacterial honey dressing material has in palatal wound healing and the subsequent effects in post-operative morbidity.
- Trial name
- NCT04269694
- Testing
- Medihoney dressing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Cellulitis
Effect of Teledermatology on Length of Hospital Admission, Length of Stay, 30 Day Readmission Rate, and Antibiotic Use in Patients Presenting With Cellulitis vs Pseudocellulitis in an Academic ED Setting
The effect of teledermatology on length of hospital admission, length of stay, 30 day readmission rate, and antibiotic use in patients presenting with cellulitis vs pseudocellulitis in an academic emergency department setting.
- Trial name
- NCT03036358
- Testing
- teledermatology consult, Routine Care
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthcare Associated Infection
Copper Use as Protection Against Antimicrobial Resistance in the ICU
CUPRIC is an investigator initiated and conducted, prospective, quasi-experimental study to determine whether the combined use of copper-alloyed objects plus copper-enriched textiles reduce the burden of MDRO colonization and…
- Trial name
- CUPRIC (NCT04873557)
- Testing
- Copper-based surfaces plus copper-enriched linen
- Where
- Chile
- Volunteers
- 168 people
- Sponsor
- Universidad del Desarrollo
Bloodstream Infection, Acute Myeloid Leukemia
Efficacy of Antibiotic Short Course for Bloodstream Infections in Acute Myeloid Leukemia Patients With Febrile Neutropenia
There is no specific recommendation about antimicrobial treatment length for documented infections in chemotherapy induced febrile neutropenia.
- Conditions
- Bloodstream Infection, Acute Myeloid Leukemia, Febrile Neutropenia
- Trial name
- NCT04910698
- Testing
- Antibiotic
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Poitiers University Hospital
Antimicrobial Stewardship, Acute Bronchitis
Using Behavioral Science to Reduce Inappropriate Antibiotic Use in Acute Care Settings
Stepped wedge behavioral intervention clinical trial looking at the impact of an antibiotic stewardship intervention on provider prescribing behavior for acute respiratory infections (ARIs), where the intervention is administered…
- Conditions
- Antimicrobial Stewardship, Acute Bronchitis, Upper Respiratory Infection
- Trial name
- NCT03711292
- Testing
- Antibiotic Stewardship
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Non-Tuberculous Mycobacterial Pneumonia
Prolonged-Use of Inhaled Gaseous Nitric Oxide (gNO) for Adult With Non-Tuberculous Mycobacteria Infection
An open labeled Study (NCT03331445) is demonstrating encouraging safety and efficacy results for most subjects receiving 160ppm nitric oxide gas (gNO) for treatment of non-tuberculous mycobacteria (NTM) over a 15 day treatment…
- Trial name
- NCT03473314
- Testing
- Nitric Oxide gas at 160ppm
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Urinary Tract Infection
Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI
In this study, patients with uncomplicated urinary infection are investigated. It is investigated if treatment of only symptoms of the uncomplicated urinary infection is as effective as treatment with antibiotics with respect to…
- Trial name
- NCT01488955
- Testing
- Ibuprofen, Fosfomycin-Trometamol
- Where
- 2 sites in Germany
- Volunteers
- 494 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH