Clinical trials: Antibiotics Resistance
Diarrhea Travelers, Antibiotic Resistant Infection
Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea
The purpose of this study is to determine if the use of prophylactic bismuth subsalicylate (BSS) has an effect on the acquisition of travelers' diarrhea (TD) or antimicrobial resistance (AMR) genes in fecal samples among…
- Trial name
- NCT03535272
- Testing
- Bismuth subsalicylate
- Where
- United States
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Antibiotic Side Effect, Antibiotic Resistant Infection
Antibiotic Use and Resistance KAP Among Dental Interns
The study is designed as a cross-sectional online-based questionnaire, and it will be distributed among dental interns. Assess the following among dental interns (1) The knowledge, attitude, and practices (KAP) towards…
- Trial name
- NCT06383637
- Volunteers
- 343 people
- Sponsor
- Cairo University
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Antimicrobial Resistance
Algorithm Using a Rapid Diagnostic Test for the Management of Childhood Febrile Diseases.
In Sub-Saharan Africa (SSA), fever remains a major public health problem in children. The introduction of malaria rapid diagnostic tests (RDTs) in routine healthcare has greatly improved the management of malaria.
- Trial name
- e-MANIC (NCT05285657)
- Testing
- Two-step malaria RDT detecting PfHRP2/pLDH (SD Ag Bioline Malaria Ag P.f/Pan: Standard Diagnostics, Hagal-Dong, Korea)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 1,176 people
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Multi-antibiotic Resistance
Fecal Transplant for MDRO Decolonization
This is a trial designed to determine whether fecal microbiota transplantation (FMT) can eliminate highly drug-resistant bacteria from the intestinal tract of renal transplant patients.
- Trial name
- NCT04181112
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University of British Columbia
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Abscesses
Prospective Randomized Trial of Bactrim on 7 Day Outcome in Patients With Uncomplicated Abscesses
Patients will be enrolled in a multi-center study to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. All patients will receive incision and drainage and wound cultures.
- Trial name
- NCT00973765
- Testing
- bactrim
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Urinary Tract Infection(UTI), Antimicrobial Stewardship
Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care
Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis…
- Conditions
- Urinary Tract Infection(UTI), Antimicrobial Stewardship, Primary Care
- Trial name
- NCT07246837
- Testing
- MSCC Educational Tool
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Baylor College of Medicine
Extended Spectrum Beta Lactamases (ESBL) E. Coli
Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Coli
This study is to identify and isolate well-defined microbials (non-ESBL E. coli) in an observational setting exploring natural gastrointestinal decolonization of humans colonized with ESBL E. coli.
- Trial name
- NCT04764500
- Testing
- examination of stool sample, patient questionnaire, examination of blood sample
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Bacterial Colonization
Bacterial Decolonization Within Dyads
The goal of this study is to measure bacterial burden, specifically Staph aureus, and how it spreads between mothers and their infants.
- Trial name
- BADMC (NCT06541145)
- Testing
- Mupirocin, Chlorhexidine baths
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Prescribing, Off-Label
CMO Letter to Reduce Inappropriate Antibiotic Prescribing Winter 2019/2020
This trial aims to reduce inappropriate prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- NCT04051281
- Testing
- Letter
- Where
- United Kingdom
- Volunteers
- 2,963 people
- Sponsor
- Public Health England
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Bacteremia, Antimicrobial Stewardship
Knowledge Attitude and Practice Regarding Bloodstream Bacterial Infections and Antibiotics Usage Among Doctors.
This study is designed to use a questionnaire to assess doctors' knowledge, attitudes, and practices regarding bloodstream bacterial infections and antibiotic use in Tawam and Al Ain tertiary Hospitals (both hospitals have the…
- Conditions
- Bacteremia, Antimicrobial Stewardship, Antibiotic Use, Antibiotic Abuse
- Trial name
- NCT06605677
- Testing
- Questionnaire
- Where
- United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- Abu Dhabi Health Services Company
Bacteremia
Surveillance of AMR in DRC
This study addresses knowledge gaps regarding antimicrobial resistance (AMR) in sub-Saharan Africa, focusing on evaluating the feasibility of AMR surveillance and enhancing local research capacity.
- Trial name
- SARKIN (NCT06821282)
- Where
- Democratic Republic of the Congo
- Volunteers
- 210 people
- Sponsor
- University of Oxford
Antibiotic Resistant Strain
Autologous Fecal Microbiota Transplantation to Prevent Antibiotic Resistant Bacteria Colonization
This study, a Randomized controlled trial of Autologous microbiome reconstitution to prevent Colonization by antibiotic rEsistant bacteria (RACE), seeks to investigate the safety, feasibility and the role of autologous fecal…
- Trial name
- RACE (NCT03061097)
- Testing
- Autologous fecal microbiota transplant (Auto-FMP Enema)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Research Institute
Community-acquired Pneumonia, Air Pollution
The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population
Objectives: To test the hypothesis that certain levels of air pollution may lead to increases in 1) antimicrobial consumption in the general population and 2) the presence of antibiotic resistance genes.
- Conditions
- Community-acquired Pneumonia, Air Pollution, Drug Resistance, Microbial
- Trial name
- ONAIR (NCT04662047)
- Where
- Spain
- Volunteers
- 3,249,128 people
- Sponsor
- Hospital Universitari de Bellvitge
Samples From Patients With Enterococcal Infections
Characterization of Enterococci
Study on Characterization of Enterococci because nowadays it become an important cause of nosocomial infections .detection of the most common two species of Enterococci and most common virulence factors \& its genes with…
- Trial name
- NCT04777240
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Sohag University
Complicated Urinary Tract Infections, Antibiotic Resistance
Cefepime/Enmetazobactam for Bacteremic Complicated Urinary Tract Infections
This study is designed to better understand how well a new antibiotic combination, cefepime/enmetazobactam (FEP/META), works in patients with complicated urinary tract infections that have spread to the bloodstream (bacteremia).
- Trial name
- CP-CUTI (NCT07725848)
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Increased Re-eradication Rate of Helicobacter Pylori by Adding N-acetylcystein or Metronidazole to the Triple Therapy
Compare efficacy and safety of 10-day triple therapy (rabeprazole, clarithromycin and amoxicillin) plus N-acetylcystein versus 10-day concomitant therapy (rabeprazole, clarithromycin, amoxicillin and metronidazole) for…
- Trial name
- NCT01572597
- Testing
- 10RAC+acetylcystein, 10RAC+metronidazole
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Abscess
Trial of Antibiotic Treatment for Skin Abscess in Patients at Risk for Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection
Patients will be enrolled in a multi-center study to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. All patients will receive incision and drainage and wound cultures.
- Trial name
- NCT00829686
- Testing
- Septra
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing