Clinical trials: Antibiotics Resistance
Methicillin-resistant Staphylococcal Infections
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability…
- Trial name
- OPTIBAYE (NCT02694458)
- Testing
- Early vancomycin monitoring and bayesian dosage adjustment, usual vancomycin dose and monitoring strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extended Spectrum Beta Lactamases (ESBL) E. Coli
Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Coli
This study is to identify and isolate well-defined microbials (non-ESBL E. coli) in an observational setting exploring natural gastrointestinal decolonization of humans colonized with ESBL E. coli.
- Trial name
- NCT04764500
- Testing
- examination of stool sample, patient questionnaire, examination of blood sample
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarticular Material Infection
Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacteria
In the event of suspected osteoarticular material infection (OAMI), broad-spectrum probabilistic antibiotic therapy is recommended immediately after revision surgery.
- Trial name
- HOPE (NCT07058415)
- Testing
- Stool sample 1, Stool sample 2, Stool sample 3
- Where
- 4 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gonorrhea
Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria gonorrhea isolates from men with symptomatic urethritis seen at an STD clinic.
- Trial name
- NCT00692822
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Infection, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Determine Guide Rapid Antibiotic Treatment for Serious Infections
Military service members and the U.S. veteran population face a growing and serious health threat: widespread antibiotic resistance resulting from resistant bacteria and a dwindling pipe-line of sufficiently potent antibiotics.
- Conditions
- Infection, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- RAMPED (NCT02060513)
- Where
- 3 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- Connie Price
Enterobacteriaceae Infections
Enterobacteriaceae Producing Extended-spectrum β-lactamases (ESBL) Decolonization Study
Multidrug-resistant Enterobacteriaceae producing extended-spectrum β-lactamases (hereafter called ESBLs) have emerged as an important cause of bloodstream infection in hospitalized patients and urinary tract infections in the…
- Trial name
- NCT00826670
- Testing
- Decolonization
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- University Hospital, Geneva
Helicobacter Pylori Infection
Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Currently, a 10-day concomitant therapy has been reported to be equally effective and safe to the 10-day sequential therapy for 1st-line anti-Helicobacter pylori(H. pylori) therapy.
- Trial name
- NCT01265069
- Testing
- high dose dual therapy, concomitant therapy
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
SARS-CoV Infection, Antimicrobial Stewardship
Analysis of the Quality and Quantity of Antibiotic Prescriptions for Bacterial Respiratory Tract Superinfection in Patients Hospitalized in COVID-19 Wards
In this prospective observational study, a quantitative and qualitative analysis of antibiotic prescriptions for presumed respiratory tract (super)infection in patients hospitalized on COVID-19 wards will be made.
- Conditions
- SARS-CoV Infection, Antimicrobial Stewardship, Respiratory Tract Infections, Antibiotic Resistance
- Trial name
- NCT04544072
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitair Ziekenhuis Brussel
Atopic Dermatitis (AD), Scabies
Secondary Bacterial Infections and Nasal Colonization in Scabies and Atopic Dermatitis
This prospective observational study will evaluate the microbiological profile of secondary bacterial infection and nasal colonization in participants with scabies or atopic dermatitis.
- Conditions
- Atopic Dermatitis (AD), Scabies, Impetigo
- Trial name
- NCT07813611
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Severe Infections Pneumonia With Invasive Ventilation in PICU
RAPid SOlution for Diagnosis of Respiratory Infection in Pediatric Intensive Care Unit
In patients with infectious pneumonitis, the FILMARRAY® Pneumonia Plus Panel technique (multiplex PCR) on a respiratory sample makes it possible to identify the responsible pathogen and its resistance to antibiotics in less than…
- Trial name
- RAPSODI (NCT04773704)
- Testing
- FILMARRAY® Pneumonia Plus Panel technique
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Staphylococcus Isolates
Detection of Clindamycin Resistance Antibiotic Genes Among Staphylococcus Isolates by Using Real Time PCR
Detection of Clindamycin Resistance Antibiotic Genes among Staphylococcus Isolates by Using Real Time PCR
- Trial name
- NCT04933019
- Testing
- Detection of Clinclidamycin Resistance Antibiotic Genes among Staphylococcus Isolates by Using Real Time PCR
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Intestinal Colonization With Multidrug-resistant Bacteria
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
This investigator initiated,international, multicenter open-label, randomized controlled trial aims to assess whether a 5 day course of oral nonabsorbable antibiotics (colistin sulfate 2 million IU per os 4x/day and neomycin…
- Trial name
- R-GNOSIS WP3 (NCT02472600)
- Testing
- Colistin, Neomycin, Fecal microbiota transplantation (FMT)
- Where
- 4 sites in France, Israel and 2 more
- Volunteers
- 39 people
- Sponsor
- Stephen Harbarth
Cirrhosis
Study Of Bacterial/Fungal Infections in Hospitalized Patients With Liver Cirrhosis in China
This is a national, investigator-initiated, multicenter, prospective, observational, web-based registry in hospitalized patients with cirrhosis across China.
- Trial name
- SONIC (NCT03676777)
- Where
- 23 sites in China
- Volunteers
- 1,232 people
- Sponsor
- Ruijin Hospital
ESBL Producing E.Coli, ESBL Producing K.Pneumoniae
Epidemiology of Resistant Microbial Strains Among Different Groups of People (Healthy, Infected and Exposed to Animals)
This study investigates carriage rate and risk factors for acquiring multiresistant bacteria (ESBL producing E.coli and K.pneumoniae, carbapenem-resistant and multidrug resistant P.aeruginosa, MRSA and VRE) in hospitalised…
- Conditions
- ESBL Producing E.Coli, ESBL Producing K.Pneumoniae, Multidrug Resistant P.Aeruginosa, Carbapenem Resistant P.Aeruginosa
- Trial name
- ABRESIST (NCT03343119)
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Cholangitis Acute, Biliary Tract Diseases
Antimicrobial Resistance in Acute Cholangitis
This study prospectively explores antimicrobial resistance in patients with acute cholangitis undergoing ERCP procedures. By analyzing patient profiles, microbial cultures, and treatment outcomes, the current study seeks to…
- Conditions
- Cholangitis Acute, Biliary Tract Diseases, Jaundice; Malignant, Jaundice, Obstructive
- Trial name
- ARISE (NCT06197984)
- Testing
- ERCP
- Where
- Romania
- Volunteers
- 1,435 people
- Sponsor
- Emergency County Hospital Pius Brinzeu; Timisoara, Romania
Bacterial Resistance to Antimicrobial
Prevalence of Digestive Carriage of Integrons
Bacterial resistance to antimicrobials is an increasing problem. Doctors occasionally face genuine therapeutic dead-ends, when attempting to cure nosocomial infections and, more and more frequently, community-acquired infections.
- Trial name
- APIHA (NCT01985217)
- Where
- France
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Acute Respiratory Infection, Influenza-like Illness
Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care
The ImpProGUIDE study aims to find out whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can help to reduce antibiotic prescribing in primary care.
- Trial name
- ImpProGUIDE (NCT07396428)
- Testing
- Training Session on acute respiratory infection guideline within a multifaceted implementation strategy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Hematopoietic Stem Cell Transplantation, Vancomycin-Resistant Enterococci
Theraworx Bath Wipes Versus Standard Bath Wipes in the Reduction of Vancomycin-Resistant Enterococci
Healthcare-associated infections (HAI) are associated with substantial morbidity, mortality and health-care costs in children undergoing hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT02241005
- Testing
- Theraworx™ bath wipes, Standard bath wipes
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- St. Jude Children's Research Hospital
Antimicrobial Drug Resistance
A Complex Intervention to Promote Appropriate Antibiotic Use Among Rural Residents Based on the Metaphor-Embedded Integrated Behavioral Model
The study aims to address the question of how to provide effective health education on health topics with high medical specialisation (e.g.
- Trial name
- NCT06967766
- Testing
- health education based on the Metaphor-Embedded Integrated Behavioral Model
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Bo Yan
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital