Clinical trials: Antibiotics Resistance
Vesicoureteral Reflux, Urinary Tract Infections
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)
In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infecton, we evaluated the efficacy…
- Trial name
- RIVUR (NCT00405704)
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- 19 sites in United States
- Volunteers
- 607 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Antimicrobial Resistance, Colonization
Fecal Microbiota Transplantation for CRE/VRE
Multidrug-resistant organisms (MDRO) present an increasingly serious public health threat to the global community.The prevalence of various MDRO, including carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant…
- Trial name
- NCT03479710
- Testing
- FMT infusion
- Where
- Hong Kong
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gram-Positive Bacterial Infections
Study Evaluating Vancomycin-Resistant Enterococci in a Hematology Unit
To determine the impact of the restriction of the third and forth generation cephalosporins on the reduction of intestinal colonization or infection with vancomycin-resistant enterococci (VRE) in a surgical intensive care unit…
- Trial name
- NCT00167960
- Testing
- Piperacillin/tazobactam and other β-lactam/β-lactamase
- Where
- 2 sites in South Korea
- Volunteers
- 1,500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Hospital-acquired Infections
Mortality Related to AMR in Patients With Hospital-acquired Infection
This is a prospective surveillance study to estimate excess deaths due to and risk factors associated with antibiotic-resistant infection among patients with hospital-acquired infection (HAI) in a resource-limited setting.
- Trial name
- HAMR (NCT03411538)
- Testing
- Collect data on clinical history
- Where
- Thailand
- Volunteers
- 2,069 people
- Sponsor
- University of Oxford
Antibiotic Resistant Infection, Carbapenem-Resistant Enterobacteriaceae Infection
Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals
Carbapenem resistant Enterobacteriaceae (CRE) colonization of patients discharged from hospitals is a source of transmission to the community.
- Trial name
- I-CRECT (NCT05871476)
- Testing
- Hospital Cohort Care Intervention at the hospital, , Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention
- Where
- Vietnam
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hanoi University of Public Health
Clostridium Difficile Infection, VRE Infection
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
Throughout project, the investigators design, evaluate and disseminate infection control and antibiotic stewardship (ABS) measures aimed at reducing the incidence of Clostridium difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, VRE Infection, Nosocomial Infection, MRGN Bacteria
- Trial name
- ABSOLUTE (NCT03250104)
- Testing
- Infection Control, Antibiotic Stewardship
- Where
- Germany
- Volunteers
- 80,000 people
- Sponsor
- University Hospital of Cologne
Multi-antibiotic Resistance
Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient
The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania.
- Trial name
- NCT06370299
- Testing
- (exposure of) MDR carriage
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
Uncomplicated Urinary Tract Infection, Antibiotic Resistant Infection
Establish the Relationship Between Shift in Prescribing Pattern and Associated Shift in Sensitivity Pattern of Causative Microbes in UTI Patients in a Closed Community
To establish a relationship between changed prescribing pattern and associated shift in sensitivity trend of causative microbes in patients of uncomplicated urinary tract infection in a closed community
- Trial name
- UTI (NCT03716804)
- Testing
- Tablet Nitrofurantoin, Tablet Ciprofloxacin/ Tablet Cefixime/ Tablet Cefuroxime
- Where
- Bangladesh
- Volunteers
- 62 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Renal Transplant
Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt
This is a hypothesis-generating pilot study. The intent is to model the impact of perioperative practices on the intestinal microbiome and possibly associate these conditions with the final microbiome status (e.g., number of…
- Trial name
- COMET-DR (NCT03043339)
- Testing
- Stool Specimen Collection, Anal Swab Sampling, Short Diet Assessment (SDA)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Antimicrobial Resistance
Surveillance of Healthcare-associated Infections & Antimicrobial Resistance
The aims of this project, called "Surveillance of Healthcare-associated infections \& Antimicrobial Resistance", or "SHARE", are to 1) enhance laboratory capacity to detect emerging AMR patterns; 2) strengthen hospital…
- Trial name
- NCT05734391
- Testing
- Routine Infection control
- Where
- 2 sites in United States, Botswana
- Volunteers
- 642 people
- Sponsor
- University of Pennsylvania
Abdominal Pain, Children
Resistance of Helicobacter Pylori to Antibiotics in Children
Helicobacter Pylori (HP) is one of the most common pathogens in humans. This infection can present in children with abdominal pain, vomiting and iron deficiency.
- Conditions
- Abdominal Pain, Children, Bacterial Infection Due to Helicobacter Pylori (H. Pylori), Antibiotic Resistant Strain
- Trial name
- NCT01902589
- Testing
- Helicobacter Pylori Culture
- Where
- Israel
- Volunteers
- 115 people
- Sponsor
- HaEmek Medical Center, Israel
Helicobacter Pylori Infection
Tailored Vs. Empirical Helicobacter Pylori Infection Treatment
Helicobacter pylori (Hp) is a gram-negative bacterium that colonizes human gastric mucosa and is associated with chronic gastritis that can progress to severe complications such as peptic ulcer disease, gastric adenocarcinoma and…
- Trial name
- NCT06200779
- Testing
- Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days
- Where
- Portugal
- Volunteers
- 160 people
- Sponsor
- Manuel Coelho da Rocha
Gram-positive Bacterial Infections, Staphylococcal Infections
Oral Antibiotic Treatment at Home Instead of Intravenous Treatment in Hospital for Resistant Gram Positive Infections
The main purpose of this study is to find out whether changing the hospital policy to allow switch from glycopeptide antibiotics (given by intravenous drip), to an equally effective oral antibiotic (linezolid) will enable…
- Trial name
- NCT00501150
- Testing
- linezolid
- Where
- United Kingdom
- Volunteers
- 211 people
- Sponsor
- Imperial College London
Malignant Otitis Externa
Microbiological Screening Of Malignant Otitis Externa Patients Presenting at Sohag University Hospitals
This is a prospective study to identify the bacterial and fungal organisms causing Malignant Otitis Externa (MOE) in patients presenting to Sohag University Hospitals.
- Trial name
- MOE Screening (NCT07790679)
- Testing
- ear swab and susceptibility testing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Carbapenem-Resistant Enterobacteriaceae Infection, KPC
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections
This is an observation study comparing prospective use of Imipenem/Cilastatin/Relebactam (IMI/REL) to retrospective data using Meropenem/Vabobactam (MVB)and Ceftazidime/Avibactam CZA) in treatment of Klebsiella Producing…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, KPC, Gram-Negative Bacterial Infections, Antibiotic Resistant Infection
- Trial name
- NCT04785924
- Testing
- Imipenem+Relebactam
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Multi-antibiotic Resistance
Pathway From Functional Disability to Antimicrobial Resistance in Nursing Home Residents
Multidrug-resistant organisms (MDROs) are endemic in nursing homes (NHs) with prevalence rates surpassing those in hospitals. The aim of the study is to design and evaluate the effectiveness of a multi-component intervention to…
- Trial name
- NCT02909946
- Testing
- Multi-modal Infection Control Program
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- University of Michigan
Musculoskeletal Infection, Chronic Rhinosinusitis (Diagnosis)
Establishing Personalized Phage Therapy and Its Comparative Cost in Difficult-to-treat Infections (EPHICACI)
EPHICACI is a multicenter, prospective study that continues and expands the monocentric PHAGEFORCE registry initiated at UZ Leuven.
- Conditions
- Musculoskeletal Infection, Chronic Rhinosinusitis (Diagnosis), Persistent Bacteremia, Pulmonary Infection
- Trial name
- EPHICACI (NCT06368388)
- Testing
- Prospective data collection phage therapy, Prospective data collection standard-of-care
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pneumonia, Ventilator-Associated, Hospital-acquired Pneumonia
Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in Norway
HVAPNOR consists of Three work packages: 1. Prospective observational study of Hospital (HAP) - and ventilator-Associated pneumonia (VAP) at 5 hospitals in Norway.
- Conditions
- Pneumonia, Ventilator-Associated, Hospital-acquired Pneumonia, Infectious Disease, Infection, Hospital
- Trial name
- HVAPNOR (NCT04381247)
- Testing
- Molecular diagnostics in HAP and VAP
- Where
- Norway
- Volunteers
- 550 people
- Sponsor
- Vestre Viken Hospital Trust
Helicobacter Pylori Infection
Primary Antimicrobial Resistance Patterns of Austrian Helicobacter Pylori Clinical Isolates
Helicobacter pylori infects ~ 50% of the world's population and a quarter of the European population. H. pylori is responsible for a large proportion of gastric and duodenal ulcers and gastritis. Chronic infection with H.
- Trial name
- NCT02925091
- Volunteers
- 2,000 people
- Sponsor
- Medical University of Vienna
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.
The aim of our study will be to assess in an open-label, multicenter, randomized controlled trial whether a tailored therapy guided by a non-invasive antibiotic susceptibility test on stool samples achieves higher Helicobacter…
- Conditions
- Helicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant Strain
- Trial name
- THD-HP (NCT04107194)
- Testing
- Pantoprazole 40mg, Amoxicillin 1000 MG, Clarithromycin 500mg
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- University of Bari