Clinical trials: Antibiotics Resistance
Cystic Fibrosis
Bacterial Gene Profiling to Predict Antibiotic Resistance During Cystic Fibrosis Pulmonary Exacerbations
Pulmonary exacerbations (PEx) are key events that lead to a decline in health status among CF patients, with many never recovering to baseline health.
- Trial name
- NCT04341532
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Jewish Health
Sexually Transmitted Diseases, Bacterial, Bacterial Urinary Tract Infection
UROGEN WELL D-ONE : Evaluation of a Novel Diagnostic for Sexually Transmitted Bacterial Infections
UROGEN WELL D-ONE Principal research question: Can the UROGEN WELL D-ONE assay detect urinary tract infections and urethritis in clinical samples from patients attending Genitourinary Medicine outpatient clinics as accurately as…
- Conditions
- Sexually Transmitted Diseases, Bacterial, Bacterial Urinary Tract Infection, Antimicrobial Resistance
- Trial name
- NCT04182230
- Testing
- No intervention. This study was an evalution with no intervention.
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Antibiotic Resistant Strain
Carbapenem and Quinolone Resistance in Klebsiella Pneumoniae
Klebsiella pneumoniae is an important pathogen that frequently causes nosocomial community-acquired and infections, including pneumonia, urinary tract infections, bloodstream infections, pyogenic liver abscesses, and septic…
- Trial name
- NCT03767283
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection
Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for Rescue Treatment of Hp Infection
Up to now, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of high-dose dual therapy (HDDT) and bismuth-containing quadruple therapy (BQT)…
- Trial name
- NCT02490839
- Testing
- High-dose dual therapy (rabeprazole, amoxicillin), Bismuth-containing quadruple therapy (rabeprazole, tripotassium dicitrate bismuthate, metronidazole, tetracycline)
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Multi Drug Resistant, Dysphagia
Evaluation of the Variation of the Intestinal Microbiota and the Integrity of the Intestinal Barrier in Patients With M.D.R. Germ-induced Pneumonia Undergoing Enteral Nutrition
The study aims to evaluate the effects of enteral nutrition in subjects with MDR on the intestinal microbiota
- Trial name
- NCT06485791
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Malnutrition
Optimising Antibiotic Treatment for Sick Malnourished Children
Children with severe malnutrition who are admitted sick to hospitals have a high mortality, usually because of infection. All children with severe malnutrition admitted to hospitals are treated with antibiotics.
- Trial name
- FLACSAM-PK (NCT02746276)
- Testing
- Ceftriaxone, Metronidazole
- Where
- Kenya
- Volunteers
- 81 people
- Sponsor
- University of Oxford
Antimicrobial Resistance
Resistance Profile of Escherichia Coli in Infections of Community Origin: The Importance of Antimicrobial Stewardship
The main objective of the study is to describe the antimicrobial resistance profile of E. coli isolated in patients from the community - defined as those with cultures collected within 48 hours of hospital admission - and…
- Trial name
- NCT06305455
- Testing
- Escherichia coli ESBL
- Volunteers
- 200 people
- Sponsor
- José Raimundo Araujo de Azevedo
Urinary Tract Infection
Microbiological Characterization and Antibiotic Resistance Profiling of Providencia Spp,: An Emerging Pathogen Isolated From Urinary Tract Infections
Aims of the Research: 1. Isolation and identification of Providencia spp. from UTIs. 2. Genotypic confirmation of Providencia isolates. 3. Determination of antimicrobial sensitivity patterns of isolated Providencia spp. 4.
- Trial name
- NCT07204769
- Testing
- Antibiotic sensitivity
- Where
- Egypt
- Volunteers
- 241 people
- Sponsor
- Assiut University
Antibiotic Drug Resistance
Fecal ESBL Resurgence During Antibiotic Treatment
Norwegian hospitals are struggling to control spread of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) in health care settings.
- Trial name
- NCT03206879
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Age-Related Macular Degeneration, Retinal Vein Occlusion
Resistance to Antibiotics in Patients Receiving Eye Injections
The administration of short courses of topical antibiotic drops before and/or after intravitreal injections is a common practice, but increasing evidence suggests this may not lower the risk of infectious endophthalmitis and…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT02126423
- Testing
- Conjunctival and nasopharyngeal swabs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Prism Vision Group
Antibiotic Resistant Infection
Opportunities for Antibiotic Optimisation and Outcomes Improvement in Patients With Negative Blood Culture (NO-BACT)
Patients with negative blood cultures represent 85-90 % from all patients with a blood culture taken during hospital admissions.
- Trial name
- NO-BACT (NCT03535324)
- Testing
- PROA for optimization, Control
- Where
- 3 sites in Spain
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Diarrhea
Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan
The purpose of this study is to learn whether bismuth subsalicylate can reduce use of antibiotics among adults with diarrhea in Pakistan.
- Trial name
- NCT02047162
- Testing
- Bismuth subsalicylate
- Where
- Pakistan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Acute Leukaemia
Amplification and Selection of Antimicrobial Resistance in the Intestine
The worldwide increase in the incidence of multidrug-resistant (MDR) pathogens is alarming. Antimicrobial treatment is a risk factor for the isolation of MDR pathogens and can therefore contribute to the observed trend.
- Trial name
- ASARI (NCT02058888)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Mycobacterium Infections, Nontuberculous
Pilot Trial of Inhaled Molgramostim in Non-tuberculous Mycobacterial (NTM) Infection
The trial is an open-label, non-controlled, multicenter, pilot clinical trial of inhaled molgramostim (recombinant human granulocyte-macrophage colony stimulating factor; rhGM-CSF) in subjects with persistent pulmonary…
- Trial name
- OPTIMA (NCT03421743)
- Testing
- Inhaled molgramostim, Antimycobacterial regimen
- Where
- 5 sites in Australia, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Savara Inc.
Antimicrobial Prescribing Practices, Antimicrobial Resistance (AMR)
Development and Implementation of Mobile Antibiograms to Optimize Empirical Antibiotic Prescriptions Among Prescribers in Tertiary Hospitals in Tanzania
Antimicrobial resistance (AMR) is a critical issue, especially in Africa, with resistance to common antibiotics reaching 100% in some areas.
- Trial name
- AMR; AMU; DDD (NCT07393308)
- Testing
- Mobile antibiogram application, standard of care
- Where
- 2 sites in Tanzania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
Sepsis
Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis
Sepsis is a disruption of homeostasis in the human body in response to bloodstream infection and is associated with a high risk of mortality.
- Trial name
- IDBIORIV (NCT06219135)
- Testing
- no intervention - Contamination group, blood sample - Bacteraemia group, no intervention - Emergency group
- Where
- 23 sites in France
- Volunteers
- 1,372 people
- Sponsor
- Hospices Civils de Lyon
Antibiotic Resistant Infection
Strategy to Prevent Transmission of Multidrug-resistant Gram-negative Organisms in ICU
1. Objective of study The purpose of this study was to investigate whether the active surveillance and preemptive isolation of multidrug-resistant Gram-negative bacteria in the intensive care unit affected the reduction of the…
- Trial name
- NCT03980197
- Testing
- Active surveillance and preemptive isolation, Control
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Sung-Han Kim
Staphylococcus Aureus
Network on Antimicrobial Resistance in Staphylococcus Aureus
Reduced susceptibility of Staphyloccus aureus to the glycopeptide antibiotic vancomycin is causing increasing concern worldwide in view of the threat of increased morbidity and mortality caused by such resistant organisms.
- Trial name
- NCT00341913
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Antibiotic Resistant Infection
Antibiotic Resistance in Global Pediatric Oncology Centers
Antibiotic resistance is one of the major health threats facing global as well as domestic populations, however it is not well characterized in pediatric patients.
- Trial name
- NCT03721562
- Where
- 5 sites in United States, El Salvador and 2 more
- Volunteers
- 560 people
- Sponsor
- St. Jude Children's Research Hospital