Clinical trials: Anticoagulant Therapy
Ischemia, Stroke
Edoxaban for TIA and Acute Minor Stroke
Transient ischemic attack (TIA) or minor ischemic stroke has a high risk of early recurrent stroke. As the golden standard, aspirin effect modestly on acute ischemic stroke, and slightly increase the risk of intracerebral…
- Conditions
- Ischemia, Stroke, Cerebral Infarction
- Trial name
- NCT02221102
- Testing
- Aspirin, edoxaban
- Where
- China
- Volunteers
- 3,700 people
- Sponsor
- Xijing Hospital
Venous Thromboembolism, Deep Venous Thrombosis
A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE
This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal…
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism
- Trial name
- MAGNOLIA (NCT05171075)
- Testing
- Abelacimab, Dalteparin
- Where
- 117 sites in United States, Australia and 18 more
- Volunteers
- 417 people
- Sponsor
- Anthos Therapeutics, Inc.
Covid19, Pneumonia
Practice of Adjunctive Treatments in Intensive Care Unit Patients With COVID-19
Rationale Many patients with coronavirus disease (COVID-19) need hospital admission for oxygen supplementation. A substantial number of patients need intensive care unit (ICU) admission for escalation of care.
- Conditions
- Covid19, Pneumonia, Thrombosis, Thromboembolism
- Trial name
- PRoAcT-COVID (NCT04719182)
- Testing
- Adjunctive therapies
- Where
- 2 sites in Netherlands
- Volunteers
- 1,011 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation New Onset
Cost-effectiveness Analysis Between Two Anticoagulation Strategies for Atrial Fibrillation in the Postoperative Period of Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft (CABG) surgery is a common intervention in patients with coronary artery disease (CAD). The presence of new postoperative atrial fibrillation / atrial flutter (POAF) occurs in 15-40% of patients…
- Trial name
- TASK-POAF (NCT05300555)
- Testing
- Rivaroxaban 20 MG Oral Tablet, Warfarin
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Deep Vein Thrombosis, Iliac Vein Thrombosis
Anticoagulant Plus Antiplatelet Therapy Following Iliac Vein Stenting
To evaluate the efficacy and safety of combination of anticoagulant and antiplatelet therapy on the patency of iliac vein at 12-month post stenting in patients with acute proximal DVT and ipsilateral iliac vein stenosis who…
- Conditions
- Deep Vein Thrombosis, Iliac Vein Thrombosis, Iliac Vein Obstruction, Iliac Vein Stenosis
- Trial name
- NCT04694248
- Testing
- Rivaroxaban, Aspirin
- Where
- China
- Volunteers
- 172 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Covid19, Venous Thromboembolism
Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial
The Michelle trial is expected to provide high-quality evidence around the role of extended thromboprophylaxis in COVID-19 and will help guide medical decisions in clinical practice.
- Trial name
- MICHELLE (NCT04662684)
- Testing
- Rivaroxaban 10 MG
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Science Valley Research Institute
Pulmonary Thromboembolisms, Anticoagulants; Increased
Personalized Anticoagulant Therapy for Pulmonary Thromboembolism
The goal of this prospective observational study is to explore the influencing factors of the efficacy and safety of anticoagulant therapy for pulmonary thromboembolism in special populations with older age, renal insufficiency…
- Trial name
- NCT06341231
- Where
- China
- Volunteers
- 4,700 people
- Sponsor
- Xiangya Hospital of Central South University
Atrial Fibrillation
Exploring the Efficacy of Once Daily Oral Rivaroxaban for Treatment of Thrombus in Left Atrial/Left Atrial Appendage in Subjects With Nonvalvular Atrial Fibrillation or Atrial Flutter
A study for subjects with atrial fibrillation (AF) or atrial flutter who are diagnosed with left atrial (LA) or left atrial appendage (LAA) thrombus. The study will assign subjects to rivaroxaban for treatment of thrombi.
- Trial name
- X-TRA (NCT01839357)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- 31 sites in Bulgaria, France and 5 more
- Volunteers
- 60 people
- Sponsor
- Bayer
Hemorrhage, Thrombosis
Adverse Drug Events in Patients on Oral Anticoagulation in the Emergency Department
Rationale: According to the latest National Survey on Care-Related Adverse Events, anticoagulants, including vitamin K antagonists (VKAs), rank first among medications responsible for serious iatrogenic accidents (37% in 2004…
- Conditions
- Hemorrhage, Thrombosis, Anticoagulant Therapy, Traumatic Hemorrhage
- Trial name
- ADEOA (NCT06692504)
- Where
- France
- Volunteers
- 2,080 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Venous Thromboembolism
Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age
To investigate the safety and tolerability of dabigatran etexilate solution in children and to obtain preliminary pharmacokinetic/pharmacodynamic data
- Trial name
- NCT01083732
- Testing
- dabigatran etexilate
- Where
- 7 sites in Canada, Italy and 4 more
- Volunteers
- 18 people
- Sponsor
- Boehringer Ingelheim
Acute Thrombosis of Deep Veins of Proximal Lower Extremity
DUTCH CAVA-trial: CAtheter Versus Anticoagulation Alone for Acute Primary (Ilio)Femoral DVT.
Rationale: Iliofemoral deep venous thrombosis (IFDVT) is associated with significant post thrombotic morbidity. The presence of both obstruction and reflux significantly increases the chances for development of post-thrombotic…
- Trial name
- NL28394 (NCT00970619)
- Testing
- Ekos endowave system thrombolysis
- Where
- 16 sites in Netherlands
- Volunteers
- 184 people
- Sponsor
- Maastricht University Medical Center
Postpartum Period, Cesarean Section Surgery
Rivaroxaban vs Enoxaparin After Cesarean Section: Laboratory Thromboprophylaxis Outcomes
Pregnancy and the postpartum period increase venous thromboembolism (VTE) risk. After cesarean section, low-molecular-weight heparin (LMWH; enoxaparin) is commonly used for short-term thromboprophylaxis, but it requires daily…
- Conditions
- Postpartum Period, Cesarean Section Surgery, VTE (Venous Thromboembolism)
- Trial name
- NCT07820670
- Testing
- Rivaroxaban, Enoxaparin 40 mg
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Wolfson Medical Center
Under Oral Anticoagulation Patients
Evaluation of the Contribution of a Pre-consultation Questionnaire on the Therapeutic Education
To assess the value of a dedicated knowledge questionnaire, filled by the patient prior consultation. Indeed, it could allow to target specific shortcomings of patients first, and help the cardiologist to prioritize the other…
- Trial name
- EDUCONSULT (NCT02907151)
- Testing
- Survey
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Anticoagulant-induced Bleeding, Dental Diseases
Intra- and Post- Operative Bleeding After Simple Dental Extraction in Direct Oral Anticoagulant Therapy
Direct Oral Anticoagulants were recently approved for medical treatment of several condition such as, non valvular atrial fibrillation, deep venous thrombosis, and others, substituting sometimes the conventional oral…
- Trial name
- NOADB (NCT03124030)
- Testing
- simple dental extraction
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Atrial Fibrillation
Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)
Some people can develop an abnormal heart beat known as "Atrial fibrillation" or "AF" that puts them at risk of developing clots in the heart.
- Trial name
- EMANATE (NCT02100228)
- Testing
- Apixaban, Parenteral heparin and/or oral Vitamin K antagonist
- Where
- 165 sites in United States, Belgium and 10 more
- Volunteers
- 1,500 people
- Sponsor
- Pfizer
Arthroplasty, Replacement, Hip, Thrombosis
Study of the Efficacy and Safety of DU-176b in Preventing Blood Clots in Patients Undergoing Total Hip Replacement
Patients who undergo total hip replacement surgery are at greater risk of getting deep vein thrombosis (blood clots). This study evaluates the safety, tolerability and effectiveness of the study drug, DU-176b, in reducing the…
- Trial name
- NCT00107900
- Testing
- DU-176b
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Daiichi Sankyo
COVID, Coronavirus Infection
A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care as a Rapid Response to (SARS-CoV-2) COVID-19 Pandemic
Coagulopathy of COVID-19 afflicts approximately 20% of patients with severe COVID-19 and is associated with need for critical care and death.
- Conditions
- COVID, Coronavirus Infection, Severe Acute Respiratory Syndrome, Thromboembolism, Venous
- Trial name
- RAPID-BRAZIL (NCT04444700)
- Testing
- Therapeutic anticoagulation
- Where
- Brazil
- Volunteers
- 465 people
- Sponsor
- University of Sao Paulo General Hospital
Venous Thromboembolism, Major Bleed
Direct Oral Anticoagulants and Venous Thromboembolism
The purpose of this study is to determine whether use of direct oral anticoagulants (DOACs) is associated with an increased risk of major bleeding compared to warfarin use, for the treatment of venous thromboembolism (VTE).
- Trial name
- NCT02833987
- Testing
- Apixaban (ATC B01AF02), Dabigatran (ATC B01AE07), Rivaroxaban (ATC B01AF01)
- Where
- Canada
- Volunteers
- 59,525 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Anticoagulants, Self Efficacy
Self-care and Self-efficacy Scale in Oral Anticoagulation Therapy
This study aims to develop and validate an index measurement tool to assess the patient's self-care self-efficacy in managing oral anticoagulation therapy (OAC).
- Conditions
- Anticoagulants, Self Efficacy, Self Confidence
- Trial name
- SCSE-OAC (NCT05820854)
- Testing
- Self-assess and reporting self-care self-efficacy levels
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital