Clinical trials: Antiemetic Therapy
Nausea, Vomiting
Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting
This study will determine if giving Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)orally will be effective as a prophylactic anti-emetic drug for patients who underwent arthroscopic rotator cuff repair under general anesthesia.
- Trial name
- NCT01984931
- Testing
- Trimebutine Maleate (NEWBUTIN SR 300 mg Tab), Metoclopramide hydrochloride monohydrate
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- CM Chungmu Hospital
Chemotherapy Induced Nausea and Vomiting
Study to Evaluate Anti-emetic Effect of Aprepitant Versus Placebo in Children and Adolescent Receiving Chemotherapy
Chemotherapy induced nausea and vomiting (CINV) is one of the few mostly observed distressing toxicity of cancer treatment. It can occur up to 90% in case of highly emetogenic chemotherapy use.
- Trial name
- Aprepitant (NCT01402024)
- Testing
- Aprepitant
- Where
- India
- Volunteers
- 96 people
- Sponsor
- All India Institute of Medical Sciences
Breast Cancer, Aromatherapy
Aromatherapy Combined With Standard Antiemetic Therapy vs Standard Therapy Alone for Prevention of CINV in Breast Cancer Patients Receiving Highly Emetogenic Chemotherapy
This phase III, multicenter, randomized, open-label trial evaluates whether aromatherapy plus standard antiemetic therapy improves complete response (CR) of CINV compared with standard therapy alone in breast cancer patients…
- Conditions
- Breast Cancer, Aromatherapy, Chemotherapy, CINV
- Trial name
- NCT07761325
- Testing
- Aromatherapy, Standard triple antiemetic therapy
- Volunteers
- 374 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia
Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia
The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing…
- Conditions
- Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia, Ceserean Section, Antiemetic Therapy
- Trial name
- NCT07740577
- Testing
- Ondansetron 4mg, metoclopramide
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Education and Research Hospital
Vomiting
The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics
This study investigates the effectiveness of combining vitamin B6 (pyridoxine) and metoclopramide compared to standard antiemetic treatments for managing nausea and vomiting.
- Trial name
- NCT06390787
- Testing
- Metoclopramide and Vitamin B6, Vitamin B6, Ondansetron
- Where
- Iraq
- Volunteers
- 250 people
- Sponsor
- University of Baghdad
Healthy Volunteers
Study to Assess Bioequivalence and Adhesion Properties Between Two Granisetron Transdermal Patches.
The study is designed to evaluate the BE and adhesion properties of granisetron transdermal patches manufactured at 2 different sites. The study has been designed in accordance with the FDA Guidance for Industry.
- Trial name
- NCT05027646
- Testing
- Sancuso - Part 1, Sancuso - Part 2
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin, Inc.
Breast Cancer
Individualised Versus Standard Care for Breast Cancer Patients at High-risk for Chemotherapy-induced Nausea and Vomiting The ILIAD Study
The purpose of this study is to evaluate whether adding olanzapine 5mg to standard antiemetic medication can significantly reduce chemotherapy-induced nausea and vomiting in breast cancer patients receiving emetogenic…
- Trial name
- NCT02861859
- Testing
- Olanzapine
- Where
- Canada
- Volunteers
- 221 people
- Sponsor
- Ottawa Hospital Research Institute
Overdose
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
This study is designed to assess the impact of new approaches to therapy for paracetamol poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
- Trial name
- SNAP (NCT01050270)
- Testing
- Ondansetron, acetylcysteine
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- University of Edinburgh
Endometrial Cancer
Akynzeo as Antiemetic Treatment in Patients With Endometrial Cancer
The clinical trial concerns the use of an innovative \"anti-emetic\" drug (that is, anti-vomiting and nausea) in subjects affected by endometrial cancer.
- Trial name
- NOEME (NCT06726291)
- Testing
- NEPA (300mg netupitant/0.5mg palonosetron)
- Where
- 8 sites in Italy
- Volunteers
- 84 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Postoperative Vomiting and Nausea
Acupuncture and Nausea/Vomiting in Pediatric Patients
The purpose of this study is to investigate the effects of intraoperative P6 acupuncture plus standard therapy on postoperative nausea and vomiting in pediatric patients undergoing tonsillectomy with or without adenoidectomy.
- Trial name
- NCT01417741
- Testing
- Acupuncture Needle
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Oregon Health and Science University
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
This randomized controlled phase III trial aims to evaluate the use of electroacupuncture in combination with olanzapine-containing standard quadruple antiemetic drugs for the treatment of nausea and vomiting induced by highly…
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06200168
- Testing
- Electroacupuncture, Standard antiemetic treatment
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jiuda Zhao
Chemotherapy-induced Nausea and Vomiting
Steroid-sparing Therapy (Olanzapine) Versus Dexamethasone-based Therapy for Chemotherapy-induced Nausea and Vomiting
The purpose of this research is to compare two drugs that are routinely used as standard of care for treating nausea and vomiting caused by chemotherapy.
- Trial name
- NCT05590923
- Testing
- OLA group: Olanzapine, DEX group: Dexamethasone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Guthrie Clinic
Transitional Cell Carcinoma
JAVLOR® Online Non-Interventional Trial
Documentation of data concerning tolerability and efficacy of the intravenous treatment with vinflunine performed under daily routine conditions in Germany.
- Trial name
- JONAS-1 (NCT01103544)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Pierre Fabre Pharma GmbH
Hematopoietic/Lymphoid Cancer, Nausea and Vomiting
Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy
This randomized phase III trial studies antiemetic therapy with olanzapine to see how well they work compared to antiemetic therapy alone in preventing chemotherapy-induced nausea and vomiting in patients with cancer receiving…
- Conditions
- Hematopoietic/Lymphoid Cancer, Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT02116530
- Testing
- Olanzapine, Chemotherapy (cisplatin or cyclophosphamide and doxorubicin), Antiemetic treatment (ondansetron or granisetron or palonosetron; plus dexamethasone; plus fosaprepitant or aprepitant)
- Where
- 177 sites in United States
- Volunteers
- 401 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Neoplasms
Chinese Herbal Acupoint Application Combined With Triple Antiemetic Therapy for Prevention of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer
The goal of this clinical trial is to learn whether Chinese herbal acupoint application, when added to standard three-drug anti-nausea treatment, can prevent nausea and vomiting caused by chemotherapy in people with breast…
- Trial name
- NCT07848984
- Testing
- Chinese Herbal Acupoint Application, Standard Triple Antiemetic Therapy
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nausea and Vomiting Caused by Chemotherapy
Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Gemcitabine Combined With Paclitaxel Protein-bound
This study aims to evaluate whether the preventive and suppressive effects of auricular point stimulation combined with dexamethasone on nausea and vomiting induced by the gemcitabine plus paclitaxel protein-bound regimen are…
- Trial name
- ADGP Ⅱ (NCT07716228)
- Testing
- Auricular point stimulation plus dexamethasone, Standard pharmacologic antiemetic regimen
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Antiemetic Therapy
Epidemiological EMESIS-Registry
The purpose of this registry is to record information on reality of anti-emetic therapies of cancer-patients in Germany. The outcome of this study is the efficacy of anti-emetic therapies dependent on the rate "complete and major…
- Trial name
- EMESIS (NCT00911222)
- Testing
- non-interventional
- Where
- Germany
- Volunteers
- 1,035 people
- Sponsor
- iOMEDICO AG
Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery
Midazolam Adjunct Therapy for Prevention of PONV in Gynecological Laparoscopy
This randomized controlled trial was conducted to evaluate the efficacy of adding midazolam to standard dual antiemetic prophylaxis with dexamethasone and ondansetron for the prevention of postoperative nausea and vomiting (PONV)…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery, Anesthesia Complications
- Trial name
- MIDOD (NCT07668700)
- Testing
- Midazolam 0.05 mg/kg IV as adjunct to dexamethasone and ondansetron for PONV prevention
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Hameed Latif Hospital, Lahore
Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer
RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients being treated with chemotherapy. PURPOSE: This randomized phase III trial is comparing how well different antiemetic drugs work in…
- Trial name
- NCT00020657
- Testing
- dolasetron mesylate, granisetron hydrochloride, ondansetron
- Where
- 15 sites in United States
- Sponsor
- Gary Morrow
Benign Headache
Bupivacaine for Benign Headache in the ED
Headache is a common chief complaint of patients presenting to the emergency department (ED), accounting for approximately 3 million ED visits per year.
- Trial name
- NCT01785459
- Testing
- 0.5% bupivacaine, Standard Care
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences