Clinical trials: Antiepileptic Drugs
Epilepsy, Seizure
Developmental Effects On Children Of Women Who Take Antiepileptic Drugs During Pregnancy
The purpose of this study is to determine if antiepileptic drugs (AEDs) differ in their neurodevelopmental effects. Specifically, do the children of the women with epilepsy differ in their behavioral and cognitive development…
- Conditions
- Epilepsy, Seizure, Cognition Disorders
- Trial name
- NCT00021866
- Testing
- Differential Abilities Scale, Neuropsychological Testing
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 331 people
- Sponsor
- Emory University
Acute Kidney Injury, Renal Insufficiency
Pharmacokinetics of Antiepileptics in Patients on CRRT
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to…
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Renal Failure, Pharmacokinetics
- Trial name
- PADRE (NCT03632915)
- Testing
- Levetiracetam, Lacosamide, Phenytoin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Maryland, Baltimore
Status Epilepticus
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
- Trial name
- RAMPART (NCT00809146)
- Testing
- Intramuscular route of active treatment, Intravenous route of active treatment
- Where
- 17 sites in United States
- Volunteers
- 1,023 people
- Sponsor
- Robert Silbergleit
Epilepsy
Clinical Study in Healthy Volunteers to Investigate the Neurocognitive Effects of a New Antiepileptic Drug: Brivaracetam
The primary objective of the study is to evaluate the neurocognitive effects of brivaracetam
- Trial name
- NCT00736931
- Testing
- Brivaracetam, levetiracetam, lorazepam
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Brain Tumor Related Epilepsy (BTRE)
Study of Lacosamide as an Adjunctive Drug Treatment for Epilepsy in Patients With Brain Tumors
This study is being conducted to find out whether lacosamide (a drug to treat epilepsy) is effective in routine clinical practice for patients with epilepsy caused by a brain tumor.
- Trial name
- VIBES (NCT02276053)
- Where
- 24 sites in France, Germany and 4 more
- Volunteers
- 93 people
- Sponsor
- UCB BIOSCIENCES GmbH
Partial Epilepsies
Trial to Assess Lacosamide as the First add-on Anti-epileptic Drug Treatment in Patients With Partial-onset Seizures
To evaluate the efficacy and safety of oral Lacosamide as first add on treatment in subjects with uncontrolled partial-onset seizures after prior treatment with a monotherapy Antiepileptic Drug (AED) regimen compared to subjects…
- Trial name
- NCT00955357
- Testing
- Lacosamide
- Where
- 109 sites in United States, Austria and 13 more
- Volunteers
- 461 people
- Sponsor
- UCB Pharma
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Epilepsy, Seizures
A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy
The purpose of this study is to compare the effectiveness and safety of topiramate to standard antiepileptic drugs in children and adults with newly diagnosed epilepsy.
- Trial name
- NCT00236717
- Testing
- Topiramate; Carbamazepine; Valproate
- Volunteers
- 865 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Epilepsy
Eslicarbazepine Acetate as Add-On Treatment to One Baseline Antiepileptic Drug (ESLADOBA)
This is a multicenter, non-interventional, prospective study. The observation period comprises at least 6 months, from the initiation of ESL add-on therapy in adult patients with partial-onset epilepsy not sufficiently controlled…
- Trial name
- NCT01532726
- Testing
- ESL
- Where
- Portugal
- Volunteers
- 56 people
- Sponsor
- Bial - Portela C S.A.
Epilepsy
Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy
The main objective of the present study will be to establish whether a slow (within 160 days) or a rapid (within 60 days) withdrawal schedule of antiepileptic monotherapy influence relapse rate in adult patients with epilepsy…
- Trial name
- RASLOW (NCT05236166)
- Testing
- Rapid withdrawal of antiepileptic, Slow withdrawal of antiepileptic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University Magna Graecia
Birth Defects, Pregnancy Complications
UCB Antiepileptic Drugs (AED) Pregnancy Registry (Formerly the Keppra® Pregnancy Registry)
This is a prospective, observational, exposure-registration and follow-up study of women and their offspring exposed to Keppra® (levetiracetam) and Keppra XR® at the time of conception (i.e., any time from the first day of the…
- Conditions
- Birth Defects, Pregnancy Complications, Epilepsy, Seizures
- Trial name
- NCT00345475
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- UCB Pharma
Epilepsy
Characterization of Epilepsy Patients BEEP 2b
Some epilepsy patients are described as GB when they have worsened seizures or side effects related to switching between brand name and generic, or between generic antiepileptic drug (AED) products.
- Trial name
- BEEP2b (NCT02707965)
- Testing
- Oxcarbazepine (brand name vs generic drugs), Divalproex Sodium (brand name vs generic drugs), Carbamazepine (brand name vs generic drugs)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Food and Drug Administration (FDA)
Epilepsy, Epilepsy, Temporal Lobe
Early Surgical Intervention to Treat Epilepsy
The purpose of this trial is to compare the effectiveness of early surgical intervention for mesial temporal lobe epilepsy to continued treatment with antiepileptic drugs.
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Seizures
- Trial name
- ERSET (NCT00040326)
- Testing
- anteromesial temporal resection, antiepileptic drugs
- Where
- 12 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of California, Los Angeles
Epilepsy
Outcome Study in Refractory Epilepsy (SOPHIE)
Over 1 million people in the European Union (EU) suffer from chronic refractory epilepsy. Their quality of life (QoL) is severely affected by seizures and by the adverse effect of antiepileptic drug (AED) treatment.
- Trial name
- SOPHIE (NCT03939507)
- Testing
- AEP score available to the treating physician
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Pavia
Bronchial Asthma
Study of Efficacy of Lamotrigine in Therapy of Bronchial Asthma
The purpose of this study is to determine whether antiepileptic drug lamotrigine is effective in the treatment of chronic asthma.
- Trial name
- NCT00153244
- Testing
- Lamotrigine
- Volunteers
- 76 people
- Sponsor
- Centre of Chinese Medicine, Georgia
Healthy
Effect of Ginkgo Biloba on Phenytoin Elimination
This study will examine how the herbal remedy ginkgo biloba may affect the body's elimination of other medicines. Many people take ginkgo biloba to improve memory, mental alertness and overall feeling of well being.
- Trial name
- NCT00011063
- Testing
- Ginkgo Biloba
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Partial Onset Seizures
A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)
This was a Non-interventional Prospective Study. Centres enrolled adult patients with partial-onset seizures with or without secondary generalisation for whom the clinician had decided to initiate Eslicarbazepine Acetate (ESL) as…
- Trial name
- NCT01830400
- Testing
- Eslicarbazepine Acetate tablets
- Where
- 106 sites in Czechia, Denmark and 6 more
- Volunteers
- 254 people
- Sponsor
- Eisai Inc.
Seizures
An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
The purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.
- Trial name
- NCT04686786
- Testing
- CVL-865
- Where
- 56 sites in United States, Australia and 5 more
- Volunteers
- 105 people
- Sponsor
- AbbVie
Epilepsy
A Study to Look at Antiepileptic Drug Levels While on Lamictal or Depakote With or Without an Oral Contraceptive
Some antiseizure medication levels are affected by hormones. This study is being done to determine if blood levels of lamotrigine or valproate are affected by the hormones in the birth control pill or the menstrual cycle itself.
- Trial name
- NCT00296413
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Beth Israel Deaconess Medical Center
Brain Neoplasms, Brain Cancer
1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients
The purpose of this study is to see if there are any differences in patient reported neurotoxicity between patients who receive Levetiracetam tablets for one week after surgery to remove a brain tumor versus those who receive…
- Conditions
- Brain Neoplasms, Brain Cancer, Brain Tumors, Cancer of the Brain
- Trial name
- NCT02334722
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Florida