Clinical trials: Antiepileptic Drugs
Partial Epilepsies
Determine Safety and Efficacy of Long-term Oral Lacosamide in Patients With Partial Seizures
The purpose of this trial is to determine whether lacosamide is safe and effective for long-term use in patients with partial-seizures from epilepsy
- Trial name
- NCT00522275
- Testing
- lacosamide
- Where
- 60 sites in United States
- Volunteers
- 308 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Epilepsy
Study of Antiepileptic Drug Effects on Child Development
The specific aim of this study is to determine if in utero exposure produces differential antiepileptic drug (AED) effects on subsequent cognitive abilities and behavioral abnormalities in children
- Trial name
- NCT00353886
- Testing
- TONI-3, WRAT-3, Connor's Rating Scales PRS & TRS
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Augusta University
Epilepsy
The Effect of Anti-epileptic Drugs on Mitochondrial Activity
This study is based on the hypothesis that antiepileptic drugs (other than Valproic acid) have an effect on the mitochondrial oxidative phosphorylation.
- Trial name
- NCT01218321
- Testing
- antiepileptic treatment
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Subarachnoid Hemorrhage
Antiepileptic Drugs and Vascular Risk Markers
The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.
- Trial name
- NCT00774306
- Testing
- phenytoin, valproate, levetiracetam
- Volunteers
- 52 people
- Sponsor
- Thomas Jefferson University
Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation
Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation
This study is being conducted in patients who will receive a spinal cord stimulator. This device helps manage chronic neuropathic pain in the trunk and/or limbs.
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- NCT07413731
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Brai²n
Neutropenia, Thrombocytopenia
Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy
Low therapeutic index of established antiepileptic drugs (AEDs) coupled with better understanding of the pathophysiology of seizure has encouraged the development of several novel AEDs.
- Conditions
- Neutropenia, Thrombocytopenia, Aplastic Anemia, Anemia
- Trial name
- NCT06491303
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy, Myoclonic Epilepsy
Effect of Levetiracetam on Brain Excitability
This study will examine the effect of the newly developed anti-epileptic drug, levetiracetam, on excitability of the cortex (surface layer) of the brain.
- Trial name
- NCT00006191
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Contraception
Women With Epilepsy: a Pilot Study of PK and PD Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users
The investigators will conduct a prospective, seven-month pilot study to explore pharmacokinetic (PK) and pharmacodynamic (PD) effects among women with epilepsy using the levonorgestrel intrauterine system (LNG IUS) for…
- Trial name
- WESAIL (NCT02362373)
- Testing
- levonorgestrel IUS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Epilepsy, Epilepsy, Focal
A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.
The purpose of this study is to demonstrate that RWJ-333369 is safe and effective as add-on treatment of partial onset seizures.
- Conditions
- Epilepsy, Epilepsy, Focal, Seizure Disorder, Complex Partial Seizures
- Trial name
- NCT00433667
- Testing
- RWJ-333369
- Volunteers
- 563 people
- Sponsor
- SK Life Science, Inc.
Bronchial Asthma
Antiepileptic Drug Carbamazepine in Treatment of Bronchial Asthma
The purpose of this study was evaluation the efficacy of antiepileptic drug carbamazepine in the treatment of mild-to-severe bronchial asthma.
- Trial name
- NCT00207428
- Testing
- Carbamazepine
- Volunteers
- 65 people
- Sponsor
- Centre of Chinese Medicine, Georgia
Epilepticus; Status, Focal Motor
Perampanel in Focal Status Epilepticus
Randomized controlled trial on focal motor status epilepticus (SE), studying the add-on efficacy of the enteral administration of perampanel (PER) to a conventional intravenous antiepileptic drug.
- Trial name
- PEPSI (NCT04309721)
- Testing
- Perampanel
- Where
- 10 sites in France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alveolar Bone Loss
Bone Mineral Density and Periodontal Status in Patients on Antiepileptic Drug
Assessment of bone mineral density and periodontal parameters in patients with epilepsy. Comparative evaluation of bone mineral density and levels of marginal alveolar bone in patients with epilepsy on monotherapy, combination…
- Trial name
- NCT04262999
- Testing
- effect of sodium valproate on alveolar bone level, effect of levetiracetam on alveolar bone level, effect of sodium valproate+levetiracetam on alveolar bone level
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Infantile Spasms
Open-label Extension to Protocol 1042-0500
To allow open-label extension to patients who have completed Protocol 1042-0500
- Trial name
- NCT00442104
- Testing
- Ganaxolone
- Where
- 14 sites in United States
- Volunteers
- 54 people
- Sponsor
- Marinus Pharmaceuticals
Epilepsy
Safety of Antiepileptic Withdrawal in Long Term Video-EEG Monitoring
SAVE is a stratified cluster-randomised controlled, parallel group, open-label trial, with Epileptic Monitoring Unit (EMU) as the units of randomisation and patients as the unit of analysis.
- Trial name
- SAVE (NCT02679846)
- Testing
- Standardized protocol
- Where
- 23 sites in France
- Volunteers
- 1,567 people
- Sponsor
- Hospices Civils de Lyon
Fibromyalgia (FM), Vitamin B 12 Deficiency
Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Fibromyalgia: Retrospective Study
Fibromyalgia is a rheumatological disorder characterised by chronic widespread body pain, second most common after osteoarthritis. The overall prevalence is 2-8% and it is more common in women.
- Conditions
- Fibromyalgia (FM), Vitamin B 12 Deficiency, Folic Acid Deficiency
- Trial name
- NCT07013305
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Epilepsy, Magnesium Deficiency
Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy
The objective of this study is to determine the role of magnesium on bone and vitamin D metabolism in patients receiving anti-epileptic medications.
- Conditions
- Epilepsy, Magnesium Deficiency, Vitamin D Deficiency
- Trial name
- NCT03471481
- Testing
- No Intervention. Study is Cross Sectional in nature
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Drexel University
Epilepsy
Epilepsy Impact Scale
The investigators are developing a questionnaire that can quickly measure the impact that epilepsy has on a person's life. This questionnaire will be useful in following whether the impact of epilepsy increases, decreases or…
- Trial name
- NCT01833234
- Testing
- Interviews and questionnaires
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Stanford University
Epilepsy
Enhancing Antiepileptic Drug Adherence
More than half of patients with epilepsy achieve full control of their seizures with antiepileptic drugs (AEDs).The study is aimed to investigate effectiveness of an educational intervention in improving medication adherence in…
- Trial name
- NCT02165306
- Testing
- Motivational Interviewing (MI), Routine counseling
- Where
- Iran
- Volunteers
- 280 people
- Sponsor
- Qazvin University Of Medical Sciences
Epilepsy, Side Effects of Drugs
Evaluation of the Incidence of Psychiatric Disorders As a Function of First-line Antiepileptic Drug Prescribing Practices: Use of Assurance Maladie Databases
An estimated 600,000 people suffer from epilepsy in France, with a prevalence of around 0.6%. The disease and its associated co-morbidities, particularly psychiatric, have a detrimental effect on the patient's quality of life.
- Trial name
- PRADOV (NCT06829693)
- Where
- France
- Volunteers
- 355,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
ZAGAL Study: Evaluating Effectiveness and Tolerability of Zonisamide as Adjunctive Therapy in Patients With Partial Onset Seizures Treated With Two Antiepileptic Drugs
The purpose of this study is to acquire additional information about the appropriate level of dosing of Zonisamide when it is prescribed for patients with partial onset epileptic crisis who are already being treated with two…
- Trial name
- NCT00659958
- Testing
- Zonisamide
- Where
- 11 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Eisai Inc.