Clinical trials: Antifungal Agents
Fluconazole, Candidiasis
Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration
The pharmacokinetics of fluconazole are expected to be different in obese patients compared to non-obese patients. The investigators will determine fluconazole and free fluconazole concentrations in 16 obese patients and 8…
- Conditions
- Fluconazole, Candidiasis, Invasive Fungal Infections, Obesity
- Trial name
- FOLIA (NCT04122560)
- Testing
- Fluconazole 200mg tab, Fluconazole 2 MG/ML
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypersensitivity
Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)
In this study researcher want to learn more about possible skin reactions such after repeated application of an antifungal cream containing Trolamine. They are especially interested in skin irritations or allergic skin reactions.
- Trial name
- NCT04531540
- Testing
- Butenafine HCl 1% (BAY1896425)
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Bayer
Gut Microbiome, Healthy Adult Male
Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial
The goal of this clinical trial is to learn how the antifungal drug fluconazole affects the gut microbiome and immune system in healthy volunteers.
- Conditions
- Gut Microbiome, Healthy Adult Male, Antifungal Therapy
- Trial name
- FAME (NCT07295314)
- Testing
- Fluconazole 200mg tab
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Scalp Dermatitis, Dermatitis
Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
The aim of this study was to investigate the changes in the scalp bacterial and fungal microbiota in subjects afflicted with a scalp seborrheic dermatitis (SSD) during a 2% ketoconazole-based treatment followed by a maintenance…
- Trial name
- NCT04057950
- Testing
- cosmetic product
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Hypersensitivity
Study to Determine Skin Irritation Potential of an Antifungal Cream Containing Trolamine After Repeated Skin Application (Cumulative Irritation Patch Test)
In this study researchers want to study the potential skin reaction after repeated application of an antifungal cream containing trolamine.
- Trial name
- NCT04531813
- Testing
- Butenafine HCl 1% (BAY1896425), Positive Control-Sodium lauryl sulfate (SLS), Negative Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Antifungal Agents
Bioequivalence (BE) Study of Test Griseofulvin 500 Milligram (mg) Tablets Versus Reference and Dose Proportionality Study of Test Griseofulvin 250 mg and 500 mg Tablets Under Fed Conditions
Griseofulvin is an antifungal agent used in treatment of Dermatophytosis caused by Microsporum spp. (species), Trichophyton spp., Epidermophyton spp., where topical therapy is considered inappropriate or has failed.
- Trial name
- NCT04318535
- Testing
- Griseofulvin 500 mg, Griseofulvin 250 mg, Reference Griseofulvin 500 mg
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Nutrition Disorders
Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers
The purpose of this study is to assess the drug concentration of Micafungin amongst healthy volunteers having different weight groups.
- Conditions
- Obesity, Nutrition Disorders, Overweight
- Trial name
- Micafungin (NCT01090141)
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dermatitis, Phototoxic
Study to Learn More About the Potential of Antifungal Cream V61-044 Containing Trolamine to Cause Irritant Reaction of the Skin to Ultra Violet Light in Healthy Human Subjects
In this study researchers want to gather information about the potential of Antifungal Cream V61-044 containing Trolamine to produce a phototoxic reaction on the skin.
- Trial name
- NCT04531527
- Testing
- Butenafine HCl 1% (BAY1896425)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Foot Infection Tinea Pedis
Glucosamine Sulphate and Ginkgo Biloba as Antifungal Activity for Treating Tinea Pedis
Tinea Pedis infected the feet of about 20-25% of the world population. Tinea Pedis is a fungal infection of the feet and it is easily spread.
- Trial name
- NCT02882438
- Testing
- infected group, control group
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ahmed A. H. Abdellatif
Periodontal Disease
Periodontal Disease Treatment of a Physically Challenged Population
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush.
- Trial name
- PDT (NCT01718912)
- Testing
- metronidazole-nystatin oral rinse
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oravital Inc
Oral Leukoplakia
Candida Associated Cytokines in Oral Leukoplakia
This study aims to determine the correlation between candida and pro- inflammatory cytokines response in Oral Leukoplakia(OL) with antifungal therapy.
- Trial name
- NCT04712929
- Testing
- Fluconazole
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Antibacterial Agents, Postoperative Dental Pain
Effect of Calcium Silicate-Based Root Canal Medicament After Retreatment
Calcium hydroxide is generally preferred in endodontics as an intracanal medicament due to its antimicrobial and biological effects. However, the antimicrobial effect of calcium hydroxide is limited.
- Conditions
- Antibacterial Agents, Postoperative Dental Pain, Antifungal Agents
- Trial name
- NCT06779370
- Testing
- Calcium Silicate, Calcium hydroxide
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Invasive Aspergillosis
F901318 Single Ascending Dose Study in Healthy Male Volunteers
F901318 is a potent new antifungal agent for the treatment of systemic fungal infections. This study will test it for the first time in man with the objective of assessing its safety, tolerability and pharmacokinetic profile.
- Trial name
- NCT02142153
- Testing
- F901318
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Fungal Infections
fungalAi for Fungal Surveillance & Antifungal Stewardship
This national Australian study will validate and implement an effective approach to real-time electronic surveillance of fungal infections in patients with blood cancers using technology based on artificial intelligence.
- Trial name
- fungalAi (NCT03793231)
- Testing
- fungalAi platform technology
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Candidosis Vaginal
Safety and Tolerability Studies of CanProFem-AK, Vaginal Suppositories in Healthy Volunteers
The study object of this clinical trial is CanProFem-AK, 100 mg suppositories. The Pharmacological group - Antifungal drug for external use.
- Trial name
- NCT06535126
- Testing
- CanProFem-AK
- Where
- Kazakhstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Industrial Microbiology LLP
Healthy
Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans
The purpose of this study, is to study the uptake of the pharmaceutical antifungal miconazole when used as a vaginal suppository in young women.
- Trial name
- NCT00668538
- Testing
- Brentan (miconazole)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Otomycosis
Antifungal Potential of Moringa Olifera Against Otomycosis
patients with Otomycosis were recognized by an ENT specialist. 20 patients were distributed randomly into two groups. The first group will be treated with Nystatin ear drops twice daily.
- Trial name
- NCT04768829
- Testing
- Moringa oleifera leaf 10mg/100ml, Ear Drop
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Deraya University
Aspergillosis
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of PC945
PC945 is a new medicine being developed for treatment of fungal lung diseases. The main purpose of this study is to investigate the safety, tolerability and pharmacokinetics of single and repeat doses of PC945
- Trial name
- NCT02715570
- Testing
- PC945 - single doses, PC945 - repeat doses
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pulmocide Ltd
Fungal Resistance
Clinical and Laboratory Evaluation of Antifungal Resistance in Tinea Capitis
AIM OF WORK : 1. Detect the most common fungal strains that cause tinea capitis 2. Detect Different effectiveness of terbinafine in different cases 3. Detect the resistant strains. 4.
- Trial name
- NCT06400056
- Testing
- Terbinafine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Antifungal Drug Adverse Reaction
An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women
To evaluate the pharmacokinetics (PK) of EE and NES released from the CVR in the presence of a single dose and multiple doses of antimycotic co-medication (miconazole nitrate suppository or cream).
- Trial name
- NCT02215395
- Testing
- NES/EE CVR
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Population Council