Clinical trials: Antimicrobial Resistance (AMR)
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Rotavirus Gastroenteritis, Rotavirus Vaccines
ROTA-biotic: Measuring the Impact of Rotavirus Vaccines on Paediatric Antibiotic Usage
Rotavirus is the most common aetiology of serious diarrhoea in young children. Despite antibiotics not being indicated in its treatment, diarrhoea remains a very common cause for antibiotic prescribing in low-income settings.
- Conditions
- Rotavirus Gastroenteritis, Rotavirus Vaccines, Antimicrobial Resistance (AMR), Antibiotic
- Trial name
- NCT06882070
- Testing
- Vaccine
- Where
- 2 sites in Ghana, Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Anti-Infective Agents, Mobile Applications
A Digital Antimicrobial Stewardship Smartphone Application to Combat AMR: the AB-assistant
Optimal prescribing of antimicrobials is becoming increasingly challenging because of the growing complexity of guidelines and constantly changing distribution of infectious pathogens.
- Conditions
- Anti-Infective Agents, Mobile Applications, Quality Improvement, Antimicrobial Stewardship
- Trial name
- AB-assistant (NCT03793946)
- Testing
- AB-assistant
- Where
- 4 sites in Canada, Netherlands and 2 more
- Volunteers
- 1,080 people
- Sponsor
- Annelies Verbon
Antimicrobial Prescribing Practices, Antimicrobial Resistance (AMR)
Development and Implementation of Mobile Antibiograms to Optimize Empirical Antibiotic Prescriptions Among Prescribers in Tertiary Hospitals in Tanzania
Antimicrobial resistance (AMR) is a critical issue, especially in Africa, with resistance to common antibiotics reaching 100% in some areas.
- Trial name
- AMR; AMU; DDD (NCT07393308)
- Testing
- Mobile antibiogram application, standard of care
- Where
- 2 sites in Tanzania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
Sepsis, Septic Shock
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
The investigators' objective is to compare the risk of treatment failure* in children admitted to the pediatric intensive care unit (PICU) with sepsis and managed by procalcitonin guided therapy for stopping of antibiotics ('PCT…
- Conditions
- Sepsis, Septic Shock, Antibiotic Use, Procalcitonin
- Trial name
- NCT03388944
- Testing
- PCT group
- Where
- 2 sites in India
- Volunteers
- 561 people
- Sponsor
- All India Institute of Medical Sciences
Drug Related Side Effects and Adverse Reactions, Infusion Reactions
Retrospective Kinetic Safety Evaluation of an Intravenous Micellar Excipient Platform
Protocol PICO-RWE-001: The goal of this observational study is to evaluate the kinetic safety and tolerability of an investigational intravenous micellar delivery platform.
- Trial name
- NCT07609069
- Testing
- PIV-850 (850-picometer Dual-NCE Acidic Matrix), Legacy Heterogeneous Payload (Micellar Vehicle)
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- PICO IV, Inc.
Antimicrobial Stewardship, Antimicrobial Resistance (AMR)
A Digital Escape Room to Teach Veterinary Students About Antimicrobial Resistance Using the One Health Approach
The goal of this study is to evaluate the effectiveness of a One Health-based educational intervention in second-year medical students from the veterinary university in Norway The main question it aims to answer is: 1.
- Trial name
- NCT07864077
- Testing
- AMRageddon
- Where
- Norway
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Antimicrobial Resistance (AMR), ESBL
One Health Determinants of Rectal Colonization by ESBL-Producing Enterobacterales in the Community
This multicenter cross-sectional observational study aims to determine the prevalence of rectal colonization by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales among community-dwelling adults in Argentina and…
- Conditions
- Antimicrobial Resistance (AMR), ESBL, Gut Microbiota Dysbiosis, Environmental Exposure
- Trial name
- NCT07818109
- Where
- Argentina
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Anti-Microbial Resistance
Antimicrobial Resistance (AMR) Study
This study aims to investigate the knowledge, attitudes and behaviours of the antibiotic resistance and prudent antibiotic use among healthcare workers in Syria
- Trial name
- NCT06944158
- Where
- Syria
- Volunteers
- 500 people
- Sponsor
- University of Aleppo
Antibiotic Resistant Strain, Transmission, Close-Contact
Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
- Trial name
- Dyaspeo (NCT06262009)
- Testing
- human faecal collection, ancillary study
- Where
- France
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization
Correlation Between Carbapenemase-Producing Enterobacterales Load, Environmental Contamination, and Transmission in Critical Care Units
Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can colonize the gastrointestinal tract of hospitalized patients and spread within intensive care units (ICUs).
- Conditions
- Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization, Antimicrobial Resistance (AMR)
- Trial name
- CPE-Load ICU S (NCT07685132)
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Covid19
Microbial Infection and AMR in Hospitalized Patients With Covid 19
To detect microbial infection and AMR associated with COVID 19 infection. To correlate risk factors of COVID 19 patients with microbial infections and their effects on disease.
- Trial name
- NCT04479982
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Antibiotic Use
Generating Collective Solutions to Reduce Unnecessary Antibiotic Use in Vietnam
The study aims to develop community-based interventions targetting inappropriate antibiotic dispensing and use behaviours in rural Vietnam and has 3 research components.
- Trial name
- NCT04358289
- Testing
- Basic antimicrobial stewardship education, Participatory action research group in commune health center and community, Antimicrobial stewardship program in hospitals
- Where
- Vietnam
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam