Clinical trials: Antimicrobial Stewardship
Upper Respiratory Infection, Acute Bacterial Sinusitis
Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer Comparison
Findings from an ongoing improvement project to improve antibiotic prescribing for children and adolescents for three acute respiratory tract infections (ARTIs: upper respiratory tract infection, acute bacterial sinusitis, and…
- Conditions
- Upper Respiratory Infection, Acute Bacterial Sinusitis, Acute Otitis Media
- Trial name
- NCT04588376
- Testing
- Peer comparison feedback monthly
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Herb Clegg
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Antibiotic Side Effect, Behavioral Changes
Improving Antibiotic Use in Urgent Care Facilities
This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare.
- Trial name
- SCORE_UC (NCT03932708)
- Testing
- CDC Core Elements of Outpatient Stewardship
- Where
- United States
- Volunteers
- 700,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Antimicrobial Stewardship, Drug Resistance, Bacterial
Optimising Community Antibiotic Use and Infection Control With Behavioural Interventions in Burkina Faso and DR Congo
Emergence of antibiotic resistance (AMR) is a serious concern for Low and Middle Income Countries (LMICs). Unregulated use of antibiotics, a major AMR driver, is highly prevalent in LMICs, with medicine stores as key providers.
- Trial name
- CABU-B/C (NCT05378880)
- Testing
- Behavioural intervention bundle to optimise antibiotic use and reduce the risk of human-to-human or environmental-animal-human transmission
- Where
- 2 sites in Burkina Faso, Democratic Republic of the Congo
- Volunteers
- 5,532 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Acute Respiratory Infection
Maltese Antibiotic Stewardship Programme in the Community (MASPIC): Antibiotic Prescribing for Acute Respiratory Tract Complaints
Antibiotic resistance has become a major threat to global public health. It is driven by a multitude of factors, however one of the leading factors is antibiotic prescribing.
- Trial name
- NCT03218930
- Testing
- Delayed antibiotic prescription, Antibiotic prescribing guidelines, Education
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Antimicrobial Stewardship, Antimicrobial Drug Resistance
Peer Comparison Feedback As An Antimicrobial Prescribing Intervention To General Medicine Specialists
The purpose of this study is to evaluate the effect of a peer comparison feedback report, combined with a best practices toolkit, on the volume of antimicrobial use by general medicine physicians.
- Trial name
- PEER AIMS (NCT07189364)
- Testing
- Peer Comparison Feedback Report
- Where
- Canada
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Fahad Razak
Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection
Optimizing Antibiotic Prescription in STI Clinics Using Rapid POCT
Sexually transmitted infections (STIs) caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are increasing in France, with a significant proportion of asymptomatic infections.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Sexually Transmitted Infections, Antimicrobial Resistance / Antibiotic Overuse
- Trial name
- OPTIMISE (NCT07884656)
- Testing
- cobas® Liat® CT/NG Point-of-Care Test
- Where
- 2 sites in France
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Appendicitis
Antimicrobial Stewardship in Pediatric Surgery
Acute appendicitis is a common surgical emergency in children. Non-perforated appendicitis patients do not require antibiotics after appendectomy.
- Trial name
- AbxPS (NCT02270996)
- Testing
- Antimicrobial Stewardship Program
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Reproductive Tract Infections
Evaluation of Immediate v. Delayed CT/NG Test for Treatment in the ED
The purpose of this study is to determine if immediate availability of GeneXpert® CT/NG test results reduces the overtreatment rate for ED patients with suspected gonorrhea or chlamydia and to assess changes in clinician…
- Trial name
- NCT01989130
- Testing
- Roche AMPLICOR CT/NG, Cepheid Xpert CT/NG Test
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- George Washington University
Antibiotic Prescribing is the Study Focus (no Condition)
Shared Decision-making and Antimicrobial Stewardship in Secondary Care
To identify opportunities for antibiotic prescribing shared decision making between patients and prescribers in secondary care.
- Trial name
- SHARE (NCT06605820)
- Testing
- None - Interview Only
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Cornwall Hospitals Trust
Acute Respiratory Infection
ASPIRE I: Supporting Antibiotic Stewardship in Primary Care Via POCT
The ASPIRE study is an uncontrolled observational feasibility study, and a collaboration between the University of South Wales and Cwm Taf Morgannwg University Health Board (CTMUHB).
- Trial name
- ASPIRE I (NCT06912022)
- Testing
- FebriDx Device
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of South Wales
Neutropenia
AMS Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients
Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy.
- Trial name
- NCT05793073
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Antimicrobial Stewardship
Evidence Based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU)
The goal of this observational study is to learn about the implementation of a process to review antimicrobial prescriptions for adult patients in Intensive Care Unit (ICU).
- Trial name
- EQUIPS-ICU (NCT06666738)
- Testing
- Structured antimicrobial review
- Where
- Vietnam
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Antibacterial Agents, Ambulatory Care
Improving Antibiotic Use for ARIs in Urgent Care Clinics
Many clinicians prescribe antibiotics for patients with acute respiratory infections even when antibiotics will not benefit the patient because the infection is due to a virus.
- Trial name
- NCT06144242
- Testing
- Feedback on RTD metric
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Daniel Livorsi
Supracondylar Humerus Fracture, Infection
Supracondylar Pinning Antibiotic Stewardship (SPAS) Trial
Prospective, multi-center, randomized controlled trial studying infection rate with or without prophylactic antibiotics at the time of closed reduction and percutaneous pinning of pediatric supracondylar humerus fractures.
- Trial name
- SPAS (NCT04288206)
- Testing
- Cefazolin, normal saline
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Antibiotic Stewardship, Overactive Bladder
Antibiotic Usage Prior to OnabotulinumtoxinA Injection
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is…
- Conditions
- Antibiotic Stewardship, Overactive Bladder, Onabotulinumtoxin A, UTI
- Trial name
- NCT04754737
- Testing
- No antibiotic, Prophylactic antibiotic, cystoscopic injection of onabotulinumtoxinA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Antimicrobial Stewardship
The Impact of the Establishment of a New AMS CPS in a Rural Hospital in Austria
Antimicrobial stewardship groups ensure the safe and prudent use of antibiotics, decrease antimicrobial resistance, lower costs of antimicrobials in hospital settings and improve patient safety in terms of prescribing…
- Trial name
- NCT05370846
- Testing
- Clinical pharmacy antimicrobial stewardship intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Antibacterial Agents
Evaluation of a Customizable Antibiotic Stewardship Program Tailored to French Nursing Homes
To tackle antimicrobial resistance (AMR), i.e., one of the top 10 global health threats, antimicrobial stewardship (AMS) programs, i.e., coherent sets of actions promoting responsible use of antimicrobials, have been developed.
- Trial name
- ORANEAT (NCT07246382)
- Testing
- The ORANEAT program
- Where
- 2 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Lorraine
Antibiotic Resistant Infection
Merck IISP Stewardship Grant for Antibiotic Best Practices
The purpose of this study is to pilot the use of best practices alerts to enhance an antimicrobial stewardship program using the electronic medical record, EPIC.
- Trial name
- NCT01573195
- Where
- United States
- Volunteers
- 1,285 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison