Clinical trials: Antimicrobial Treatment
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Dental Caries
Effect of aPDT on Deep Caries in Permanent Tooth
The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium…
- Trial name
- NCT02929914
- Testing
- Local anesthesia and rubber dam isolation, Incomplete caries removal and microbiological samples collection, Dentin washed with sodium 0.9% saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University
Sepsis Septic Shock
Bedside vs. Standard Microbiological Blood Culture Diagnostics - BEMIDIA Study
With a completely bedside blood culture diagnostics system (BACTEC blood culture system in combination with the Accelerate ID/AST System) it is possible to optimize the initial antimicrobial therapy in patients with sepsis and…
- Trial name
- BEMIDIA (NCT03000049)
- Testing
- bedside blood culture
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Medicine Greifswald
Diarrhea
Study To Evaluate The Efficacy of a Proprietary Mix of Live Probiotics In The Prophylaxis Of Diarrhea In Adult Patients
This is a double blind, randomized, placebo-controlled study. One-hundred subjects are randomized to receive either YOVIS or placebo over a period of 10 days.
- Trial name
- NCT06283784
- Testing
- Yovis Capsules
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biofarma
Sarcoidosis; Antimycobacterial Therapy
Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis
The primary purpose of this study is to investigate the efficacy and safety of oral antimycobacterial therapy in patients with confirmed progressive pulmonary sarcoidosis.
- Trial name
- NCT02024555
- Testing
- Levofloxacin, Ethambutol, Azithromycin
- Where
- 6 sites in United States
- Volunteers
- 97 people
- Sponsor
- Vanderbilt University
Infection
DetermInants of Antimicrobial Use aNd De-escalAtion in Critical Care (DIANA)
DetermInants of Antimicrobial use aNd de-escalAtion in critical care (DIANA study), is a multicenter, international, prospective, observational cohort study, aiming to describe the rate of de-escalation as well as the associated…
- Trial name
- DIANA (NCT02920463)
- Where
- Belgium
- Volunteers
- 1,495 people
- Sponsor
- University Hospital, Ghent
Aggressive Periodontitis, Generalized
Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis
The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin…
- Trial name
- NCT03132714
- Testing
- Full-mouth ultrasonic debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Acute Otitis Media
Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance
The investigators will study whether, in young children with acute otitis media (AOM), shortening length of antibiotic treatment as a strategy for reducing antimicrobial resistance provides satisfactory clinical outcome.
- Trial name
- NCT01511107
- Testing
- Amoxicillin-Clavulanate, 10 days, Amoxicillin-Clavulanate, 5 days
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Alejandro Hoberman
Lyme Disease
Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis
In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs.
- Trial name
- NCT04653558
- Where
- Slovenia
- Volunteers
- 311 people
- Sponsor
- University Medical Centre Ljubljana
Pneumonia, Bacterial, Pneumopathy
Application of the Recommendations of the SPLIF (French Society of Infectious Pathology) in a Geriatric Population on the Duration of Treatment for Bacterial Pneumonia
Pneumopathy is the leading cause of death from infectious disease in the elderly. Prior to 2021, the recommended duration of antibiotic therapy for pneumonia, in adults, was 7 days.
- Trial name
- NCT06307730
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Respiratory Tract Infections, Urinary Tract Infections
Intravenous Versus Oral Treatment of the Main Acute Infections
Patients admitted to the hospital with acute infections are often treated with intravenous (IV) antibiotics. Around 70% of these infections fall into three categories: respiratory tract infections, urinary tract infections, and…
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Cellulitis
- Trial name
- NCT06715306
- Testing
- Oral treatment
- Where
- 7 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- University of Southern Denmark
Rhinosinusitis
Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents
Chronic rhinosinusitis (CRS) is common disorder which affects up to 13% of the US population. CRS affects numerous Quality of Life (QOL) factors including smell, sleep and communication.
- Trial name
- NCT00948519
- Testing
- Laser + ICG, Laser only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York Head & Neck Institute
Abdominal (ABD) Infection
INSPIRE Trial for Abdominal Infections
The INSPIRE Abdominal Infection Trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order…
- Trial name
- NCT05423743
- Testing
- Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Abdominal Infection
- Where
- 101 sites in United States
- Volunteers
- 198,480 people
- Sponsor
- Harvard Pilgrim Health Care
Tooth Injuries, Endodontically Treated Teeth
Regenerative Endodontic Treatment of Traumatised Teeth
Aim: The aim of this prospective study was to evaluate the treatment outcomes of regenerative endodontic technique (RET) for the management of traumatised non-vital immature teeth in children.
- Trial name
- NCT03045185
- Testing
- RET using Ciprofloxacin 100mg, and Metronidazole 100mg.
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Urinary Tract Infection, Fever
Treatment's Duration of Acute Uncomplicated Pyelonephritis
The purpose of this study is to compare the efficacy of 5 days versus 10 days treatment duration in uncomplicated acute pyelonephritis.
- Trial name
- DTP (NCT00873626)
- Testing
- levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
- Where
- 2 sites in France
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bronchitis, Bronchitis, Chronic
A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefaclor, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid onset of…
- Trial name
- NCT00257140
- Testing
- levofloxacin
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Endocarditis, Bacterial, Opioid-use Disorder
Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis
Hospitalizations for severe infections associated with opioid use disorder (OUD), such as infective endocarditis (IE), have doubled in the US over the past decade and are frequently prolonged and resource-intensive.
- Conditions
- Endocarditis, Bacterial, Opioid-use Disorder, Buprenorphine, Outpatient Parenteral Antibiotic Therapy
- Trial name
- CATS-CARE (NCT03048643)
- Testing
- Outpatient parenteral antibiotic therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Laura Fanucchi
Acute Appendicitis, Acute Appendicitis With Rupture
Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous
Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous is a prospective randomized controlled trial comparing 24 hour intravenous antibacterial therapy to 24 hour oral antibacterial…
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis Without Peritonitis, Acute Appendicitis With Appendix Abscess
- Trial name
- NCT04947748
- Testing
- Oral versus intravenous administration of antibacterial treatment
- Where
- Estonia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- North Estonia Medical Centre
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Cirrhosis
Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis
Bacterial infections are a frequent complication in liver cirrhosis with a bad prognosis. However, the clinical outcome of cirrhotic patients with serious infections is significantly improved over the last 30 years due to early…
- Trial name
- NCT01820026
- Testing
- Imipenem, Vancomycin, azithromycin
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- University of Roma La Sapienza
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