Clinical trials: Antimicrobial Treatment
Abscess
Antibiotic Therapy After Incision and Drainage for Abscess
Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite…
- Trial name
- NCT00900510
- Testing
- Incision and drainage, Trimethoprim/Sulfamethoxazole (Bactrim)
- Where
- United States
- Sponsor
- Wake Forest University
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Pyelonephritis Acute, Kidney Transplant Infection
Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial.
Infections are a major cause of morbidity and mortality in solid organ transplant recipients. In kidney transplant recipients (KTR) urinary tract infection (UTI) represent 45-72% of all infections, and 30% of all hospitalizations…
- Trial name
- SHORTCUT (NCT05597540)
- Testing
- Short antibiotic treatment, Usual antibiotic treatment
- Where
- 9 sites in France
- Volunteers
- 470 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
Prophylactic Antibiotic Treatment of Patients With Chronic Obstructive Lung Disease (COLD)
The purpose of the study is to investigate, in patients with moderate to severe chronic obstructive lung disease, whether intermittent antibiotic treatment leads to: A slower rate of decline in forced expiratory volume in one…
- Trial name
- NCT00132860
- Testing
- azithromycin
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Odense University Hospital
Pneumocystis Carinii Pneumonia
Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP)
To explore the effects of corticosteroid therapy on pulmonary fibrosis and potentially pneumothorax in patients with mild PCP (pO2 >70mmHg) combined with the standard of care treatment of antibiotic therapy.
- Trial name
- NCT00636935
- Testing
- Antibiotics only, Antibiotics + Corticosteroids, Corticosteroids + antibiotics
- Where
- United States
- Sponsor
- George Washington University
Infections
Study of Blood Levels of Ceftaroline Fosamil in Children Who Are Receiving Antibiotic Therapy in the Hospital
The purpose of this study is to assess blood levels of Ceftaroline fosamil in children.
- Trial name
- NCT01298843
- Testing
- Ceftaroline fosamil
- Where
- 15 sites in United States
- Volunteers
- 53 people
- Sponsor
- Forest Laboratories
Sepsis
Sepsis Alert Routine Implementation in the Emergency Department
This study evaluates the impact of a structured sepsis alert routine, that has been implemented in the Emergency Department (ED) of Karolinska University Hospital Huddinge, Sweden.
- Trial name
- SARIED (NCT07020598)
- Volunteers
- 3,389 people
- Sponsor
- Region Stockholm
Sepsis Septic Shock
Bedside vs. Standard Microbiological Blood Culture Diagnostics - BEMIDIA Study
With a completely bedside blood culture diagnostics system (BACTEC blood culture system in combination with the Accelerate ID/AST System) it is possible to optimize the initial antimicrobial therapy in patients with sepsis and…
- Trial name
- BEMIDIA (NCT03000049)
- Testing
- bedside blood culture
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Medicine Greifswald
Surgical Site Infections, Surgical Wound Infection
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections
This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT06702878)
- Testing
- nasal antimicrobial photodisinfection therapy
- Where
- 14 sites in United States
- Volunteers
- 4,787 people
- Sponsor
- Ondine Biomedical Inc.
Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
The purpose of this study is to evaluate the effects of Ceftazidime Avibactam compared to Doripenem for treating hospitalized patients with complicated urinary tract infections, including acute pyelonephritis
- Trial name
- NCT01599806
- Testing
- Ceftazidime - Avibactam ( CAZ-AVI), Doripenem, Either switch to oral therapy: 500 mg of Ciprofloxacin (oral)
- Where
- 57 sites in United States, Argentina and 15 more
- Volunteers
- 641 people
- Sponsor
- Pfizer
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454947)
- Testing
- Clinical Decision Support (CDS): Accountable Justifications, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- 55 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Southern California
Sepsis, Severe Sepsis
Prehospital Antibiotics Against Sepsis Trial
Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PHANTASi (NCT01988428)
- Testing
- Ceftriaxone 2000 mg
- Where
- 34 sites in Netherlands
- Volunteers
- 2,672 people
- Sponsor
- Amsterdam UMC, location VUmc
Helicobacter Pylori Infection
Intraluminal Mono-antibiotic Therapy for Helicobacter Pylori Infection - A Comparison of Levofloxacin Powder and Levofloxacin Solution
Helicobacter pylori (H. pylori) is an important causal factor of chronic gastritis, peptic ulcer disease, gastric cancer and gastric lymphoma. The World Health Organization classified H. pylori as a Group 1 carcinogen in 1994.
- Trial name
- NCT03832465
- Testing
- Levofloxacin film-coated tablet, Levofloxacin intravenous solution
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Mackay Memorial Hospital
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The study proposes to assess the effect of multiple applications of antimicrobial Photodynamic Therapy (aPDT) as an adjunct to non-surgical periodontal treatment (nsPT) in smokers without use of antibiotics.
- Trial name
- NCT03039244
- Testing
- Photodynamic therapy, Control Group, Diode Laser
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Catheter Related Infections, Short Bowel Syndrome
Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome
This study is designed to determine if the use of 70% ethanol lock solution in central lines decreases the rate of central line infections in children with short bowel syndrome.
- Trial name
- NCT01263574
- Testing
- 70% ethanol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pulmonary Tuberculosis (TB)
Immune Reconstitution in Tuberculosis Disease
The aim with study is to provide adjunctive therapy with vitamin D and phenylbutyrate together with standard anti-tuberculosis treatment to significantly improve clinical recovery among patients with untreated, active pulmonary…
- Trial name
- IRETB (NCT01698476)
- Testing
- vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate)
- Where
- Ethiopia
- Volunteers
- 390 people
- Sponsor
- Karolinska Institutet
Periodontitis, Periodontal Pocket
Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Periodontitis is an inflammation of the supporting structures of the teeth, usually caused by specific or groups of microorganisms that results in the progressive destruction of the periodontal ligament and alveolar bone.
- Conditions
- Periodontitis, Periodontal Pocket, Diabetes Mellitus
- Trial name
- NCT03374176
- Testing
- Amoxicillin 500 mg / Metronidazole 250 mg, Clindamycin 300 mg
- Volunteers
- 42 people
- Sponsor
- Centro Universitario de Tonalá
Gram-negative Bacteremia, Urinary Tract Infection Bacterial
Shortened Antibiotic Treatment of 5 Days in Gram-negative Bacteremia
GNB5 is an investigator-initiated multicentre non-inferiority randomized controlled trial which aims to assess the efficacy and safety of shortened antibiotic for patients hospitalized with a Gram negative bacteremia with a…
- Trial name
- GNB5 (NCT04291768)
- Testing
- Shortened antibiotic treatment, Standard antibiotic treatment
- Where
- 13 sites in Denmark
- Volunteers
- 380 people
- Sponsor
- Thomas Benfield
Infections, Bacterial, Pharmacokinetics
Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment
The primary aim of the study is to determine the proportion of individuals receiving beta-lactam antibiotics at Imperial College Healthcare NHS Trust in whom drug concentration targets are achieved.
- Conditions
- Infections, Bacterial, Pharmacokinetics, Drug Monitoring, Drug-Related Side Effects and Adverse Reactions
- Trial name
- DATATDM (NCT06427317)
- Where
- United Kingdom
- Volunteers
- 323 people
- Sponsor
- Imperial College London
Community-acquired Pneumonia
The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)
The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice.
- Trial name
- CAP-D (NCT06295120)
- Testing
- Phenoxymethylpenicillin 1.2 MIE 4 times daily
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Research Unit for General Practice in Aalborg
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