Clinical trials: Antimicrobial Treatment
Acute Appendicitis
Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)
The ALACARTE study evaluates a strategy in which patients with acute uncomplicated appendicitis are given the choice between appendectomy and antibiotic therapy alone.
- Trial name
- ALACARTE (NCT07857252)
- Testing
- Shared decision-making, amoxicillin-clavulanate, Appendectomy
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Community-acquired Pneumonia
Delayed Antibiotic Treatment in Community-acquired Pneumococcal Pneumonia.
I. To investigate time measurement from emergency room admission to first antibiotic administration. II. To evaluate risk factors for prolonged time to first antibiotic administration. III.
- Trial name
- NCT01683487
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 122 people
- Sponsor
- University of Zurich
Burns
Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns
The aim of this study is to compare Mepitel Ag to Triple antibiotic ointment impregnated Adaptic gauze when used with the soft cast technique to assess overall time to healing, yeast infection rate and parents perception of pain…
- Trial name
- NCT02681757
- Testing
- triple antibiotic ointment dressing, Mepitel Ag
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Respiratory Disease, Acute Respiratory Infection
Dialogue Around Respiratory Illness Treatment
Unwarranted use of antibiotics for pediatric acute respiratory tract infections (ARTIs) and use of second-line, broad spectrum antibiotics for bacterial ARTIs has contributed to the rapid development of resistance in many strains…
- Conditions
- Respiratory Disease, Acute Respiratory Infection, Respiratory Infection, Upper Respiratory Infection
- Trial name
- DART (NCT02943551)
- Testing
- Online Tutorial, Webinars, Booster Sessions
- Where
- 20 sites in United States
- Volunteers
- 2,728 people
- Sponsor
- Seattle Children's Hospital
Congenital Cytomegaloviral (CMV) Disease
CMV CTLs in Neonates With CMV Infection
Patients with moderate or severe CMV disease less than 21 days old who have a maternal donor who has a CMV response to the peptivators will be screened. All patients will receive treatment with valganciclovir or ganciclovir.
- Trial name
- NCT05564598
- Testing
- CMV Cytotoxic T-Lymphocytes, Anti-viral Therapy
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- New York Medical College
Bacterial Conjunctivitis
Study of the Progression of Bacterial Conjunctivitis Symptoms Upon Antibiotic Treatment
The primary objective of this study is to investigate the initial antibiotic effects in the treatment of bacterial conjunctivitis symptoms in subjects one year of age and older.
- Trial name
- NCT00798577
- Testing
- Vigamox Ophthalmic Solution
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Helicobacter Pylori Infection
Comparison Between Ten Days Sequential Treatment and Traditional Three Combined Treatment of Helicobacter Pylori
The purpose of this study is to compare the eradication efficacy of 10-day triple therapy with 10-day sequential therapy with tetracycline or metronidazole.
- Trial name
- NCT01573975
- Testing
- 5RA-5RCM, 5RA-5RCT, 10RCA
- Where
- Taiwan
- Volunteers
- 345 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Complicated Intra-abdominal Infection
EXTENDed Antibiotic Durations Compared to Standard Durations for Patients With Complicated Intra-abdominal Infection.
A multicentre, open label, two-arm, parallel group, pragmatic, randomised controlled trial with internal pilot. A total of 1166 consenting adult patients with cIAI will be recruited and randomised on a 1:1 basis between 28-days…
- Trial name
- EXTEND (NCT05148702)
- Testing
- Antibiotic - standard duration, Antibiotic - fixed-extended-duration
- Where
- 36 sites in United Kingdom
- Volunteers
- 1,166 people
- Sponsor
- Lydia Flett
Endodontic Disease, Pulp Disease, Dental
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal…
- Conditions
- Endodontic Disease, Pulp Disease, Dental, Intracanal Medication
- Trial name
- NCT06207253
- Testing
- Diclofenac Sodium, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Acute Exacerbation of COPD
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
COPD is a common chronic disease. Its natural course is characterized by Acute exacerbations (AE). This may require hospitalization or even ICU/RESUSCITATION admission.
- Trial name
- MULTI-EXA (NCT05280132)
- Testing
- Personalized antibiotic treatment, Usual antibiotic treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
C. Difficile, Diarrhea
Impact of Oral Antibiotic Treatment on C. Difficile
The overall aim is to characterize and to compare the extent and quantity of C. difficile stool shedding, perianal colonization and environmental contamination in patients who received oral fidaxomicin, oral metronidazole, or…
- Conditions
- C. Difficile, Diarrhea, Enterocolitis
- Trial name
- C-Diff (NCT02057198)
- Testing
- Fidaxomicin, Metronidazole, Vancomycin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Diabete Type 2
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Methodology Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used.
- Trial name
- NCT07549373
- Testing
- 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Sharda University
Sepsis, PROM, Preterm (Pregnancy)
Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates
Preterm infants are born at less than 37 weeks of pregnancy. Sometimes a break or tear in the fluid filled bag that surrounds and protects the infant during pregnancy leads to an untimely birth.
- Conditions
- Sepsis, PROM, Preterm (Pregnancy), Early-Onset Neonatal Sepsis, Preterm Premature Rupture of Membrane
- Trial name
- SAUNA (NCT06377397)
- Testing
- Antibiotics
- Where
- 9 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Indian Council of Medical Research
Bone Infection, Joint Infection
Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections
For patients having a bone or joint infections, with or without device, optimal surgical therapy could be sometimes non-feasible, especially in the elderly population.
- Trial name
- NCT03403608
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Osteomyelitis
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.
The incidence of bone and joint infections (BJI) in children (osteomyelitis, septic arthritis and spondylodiscitis) is 22 per 100,000 children in France.
- Trial name
- POOMA (NCT04554108)
- Testing
- therapeutic strategy
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Infection, Joint Infection
Controlled Trial of Omadacycline Randomized Treatment Given for Bone and Joint Infection
The study design is a randomized, open-label, clinical trial of omadacycline vs Standard of Care (SOC) antibiotics for bone and join infection (BJI) treatment.
- Conditions
- Bone Infection, Joint Infection, Bone and Joint Infection
- Trial name
- CORGI (NCT05753215)
- Testing
- Omadacycline Pill, Standard of Care
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Comparison of Three Interventions for Antibiotic-Resistant Bacteria (ARB) Decolonization From the Gastrointestinal Tract
The aim of this research experiment is to evaluate the effectiveness of fecal microbiota transplantation (FMT) preceded by antibiotic pre-treatment versus probiotic therapy and a standard-of-care equivalent diet designed to…
- Trial name
- STOP-ARB3 (NCT07094984)
- Testing
- Fecal microbiota transplantation (FMT), Probiotic Therapy, Gut Microbiota Boosting Diet
- Where
- Poland
- Volunteers
- 360 people
- Sponsor
- Medical University of Warsaw
Infection, Bacterial, Antibiotic Side Effect
Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK)
Getting the right dose of antibiotic promptly is an important part of treating infections. Unfortunately, when an infection is severe (sepsis) the body changes how it processes antibiotics.
- Conditions
- Infection, Bacterial, Antibiotic Side Effect, Antibiotic Resistant Infection, Sepsis
- Trial name
- MD-PK (NCT05950984)
- Testing
- Drug Infusion Pump Monitoring
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- St George's, University of London
Vitamin d Deficiency
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.
Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (<30 ng/ml).
- Trial name
- NCT02138591
- Testing
- Blood draw pre-operatively, Blood draw post-operative Day 1, Blood draw post-operative Day 2
- Where
- United States
- Sponsor
- University of Missouri, Kansas City
Bacterial Infections.
A Single Dose Study To Investigate The Pharmacokinetics and Safety Of Dalbavancin In Hospitalized Children Aged 3 Months to 11 Years.
A phase one study to characterize the pharmacokinetics of dalbavancin in pediatric patients aged 3 months to 11 years (inclusive) following the intravenous administration of a single dose of dalbavancin.
- Trial name
- NCT01946568
- Testing
- Dalbavancin
- Where
- 12 sites in United States, Estonia
- Volunteers
- 36 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
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