Clinical trials: Antimicrobial Treatment
Diabetic Foot Ulcer
Efficacy and Safety of Garamycin® Sponge in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection
The purpose of this study is to determine whether Garamycin Sponge (Gentamicin-Collagen sponge) in combination with antibiotics is safe and effective in treating moderate and severe diabetic foot infections.
- Trial name
- NCT01951768
- Testing
- Garamycin Sponge (Gentamicin-Collagen sponge), Systemic Antibiotic
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- University Hospital, Geneva
Community-acquired Pneumonia
Short-course Antimicrobial Therapy for Paediatric Respiratory Infections
Randomized controlled double-blind non-inferiority clinical trial to determine whether five days of high-dose amoxicillin leads to comparable rates of early clinical cure compared with 10 days of high-dose amoxicillin for…
- Trial name
- SAFER (NCT02380352)
- Testing
- Amoxicillin
- Where
- 2 sites in Canada
- Volunteers
- 281 people
- Sponsor
- Hamilton Health Sciences Corporation
Prosthetic Joint Infection, Antibiotic Resistant Infection
Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk Patients
One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.
- Trial name
- NCT03848091
- Testing
- Antibiotic pretreatment
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hospices Civils de Lyon
Open Fracture, Post-Op Wound Infection
Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens
To demonstrate noninferiority of three different empiric antimicrobial regimens compared to the traditional antimicrobial regimen for the management of grade III open fractures as well as evaluate outcomes among these groups.
- Trial name
- NCT03560232
- Testing
- Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mercy Health Ohio
Pneumonia, Bacterial
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin fosfomycin inhalation system (AFIS) versus aerosolized placebo to treat Gram-negative pneumonia in mechanically ventilated patients receiving IV…
- Trial name
- IASIS (NCT01969799)
- Testing
- Amikacin fosfomycin inhalation solution
- Where
- 41 sites in United States, France and 5 more
- Volunteers
- 143 people
- Sponsor
- Cardeas Pharma
Prostate, Cancer
Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle
Objective: To determine the response to rapid hormonal cycling in patients with non-castrate prostate cancer.
- Conditions
- Prostate, Cancer, Hormonal Cycling
- Trial name
- NCT00586898
- Testing
- GnRH, Ketoconazole, Bicalutamide
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bacterial Vaginosis
Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis
Bacterial vaginosis (BV) is the most common cause of vaginitis in women of childbearing age. Women with symptomatic BV may present with malodorous discharge that is off-white, thin, and homogenous and has a fishy smell especially…
- Trial name
- NCT02042287
- Testing
- Vaginal lactic acid and glycogen gel, Metronidazole
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Wound Infection-deep, Post Operative Wound Infection
A Phase I/II Double-Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of RUT058-60
This is a double-blind, randomized, parallel-group, controlled, multi-center study to evaluate the safety and efficacy of RUT058-60 (Group A) as an intra-cavity lavage compared to sterile saline (Group B) in adult subjects…
- Trial name
- NCT02280395
- Testing
- RUT058-60, Sterile saline for irrigation
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Pulmatrix Inc.
Low Back Pain, Modic Changes Type I or II Seen on MRI
Antibiotics In Modic Changes
Low-back pain (LBP) is the single leading cause for disability worldwide, affects all age groups and has increased from 58 million years lived with disability (YLDs) in 1990 to 83 million YLDs in 2010.
- Trial name
- AIM (NCT02323412)
- Testing
- Amoxicillin (Amoksicillintrihydrat)
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
COPD Exacerbation, COPD
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
This study the investigators will examine whether procalcitonin-guided treatment regarding antibiotic therapy is non-inferior to usual care in patients who are admitted because of an acute COPD exacerbation when it comes to…
- Conditions
- COPD Exacerbation, COPD, Acute Copd Exacerbation
- Trial name
- PRECISION (NCT05854901)
- Testing
- Procalcitonin, Physician's decision
- Where
- 11 sites in Netherlands
- Volunteers
- 693 people
- Sponsor
- Erasmus Medical Center
Carbapenem Resistant Bacterial Infection, Acinetobacter Baumannii Infection
Cefiderocol vs Best Available Therapy for Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex Infections: A Target Trial Emulation
This study aims to compare 28-day mortality among patients with carbapenem resistant A. baumannii infections in two hypothetical target trials where patients receive 7 days of a cefiderocol-based treatment strategy or 7 days of a…
- Conditions
- Carbapenem Resistant Bacterial Infection, Acinetobacter Baumannii Infection, Antimicrobial Drug Resistance
- Trial name
- NCT07226557
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Vertebral Osteomyelitis, Spondylodiscitis
Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
The optimal treatment of uncomplicated native vertebral osteomyelitis (NVO) is unknown. While some authors recommend surgical treatment (consisting of spinal debridement, decompression and instrumentation using hardware…
- Conditions
- Vertebral Osteomyelitis, Spondylodiscitis, Surgical Procedure, Unspecified
- Trial name
- NCT04436328
- Testing
- Surgical treatment, Antimicrobial treatment
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Periodontitis, Surgery
Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether the use of a systemic antimicrobial (metronidazole) as an adjunct to periodontal surgery provides additional clinical and microbiological beneficial effects compared to…
- Trial name
- NCT03880448
- Testing
- Metronidazole, periodontal surgery
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Optimal Tailored Treatment for H. Pylori Infection
The efficacy of the current standard triple therapy is at an unacceptably low level. Resistance to antibiotics is suspected to be the major cause of the low efficacy of standard triple therapy.
- Trial name
- NCT04462133
- Testing
- Dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR)
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Otitis, Bronchiolitis
Pediatric and Ambulatory Research in Infectious Diseases
Many ambulatory networks are mainly based on diagnoses made by first-line physicians not specifically trained to join the network.
- Conditions
- Otitis, Bronchiolitis, Influenza, Pharyngitis
- Trial name
- PARI (NCT04471493)
- Where
- France
- Volunteers
- 400,000 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Serious Gram-Positive Bacterial Infections
Optimised Dalbavancin Dosing for Serious Gram-Positive Bacterial Infections
Serious infections caused by gram-positive bacteria often require several weeks of antibiotic treatment, which may involve prolonged hospitalisation, intravenous treatment and long-term vascular access.
- Trial name
- EDGAR (NCT07858526)
- Testing
- dalbavancin
- Where
- 2 sites in Australia
- Volunteers
- 50 people
- Sponsor
- Kirby Institute
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China.
- Trial name
- NCT03708848
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Periodontitis, Periodontal Pocket
Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Periodontitis is an inflammation of the supporting structures of the teeth, usually caused by specific or groups of microorganisms that results in the progressive destruction of the periodontal ligament and alveolar bone.
- Conditions
- Periodontitis, Periodontal Pocket, Diabetes Mellitus
- Trial name
- NCT03374176
- Testing
- Amoxicillin 500 mg / Metronidazole 250 mg, Clindamycin 300 mg
- Volunteers
- 42 people
- Sponsor
- Centro Universitario de Tonalá
Infectious Disease
Antibiotic Stewardship in Infectious Disease Departement
Consensual antibiotic protocols have been developed and validated locally by infectious disease specialists, internists and emergency physicians, in order to encourage their compliance.
- Trial name
- NCT03636711
- Testing
- antibiotic protocol, according to a syndromic approach
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gingival Recession, Gingival Recession, Generalized
Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Adjunctive Therapies
The aim of this study was to evaluate the effect of two different treatment agents used in conjunction with subepithelial connective graft technique on root coverage outcomes in multiple recession defects.
- Trial name
- NCT03462368
- Testing
- Control, antimicrobial photodynamic therapy, Photobiomodulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
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