Clinical trials: Antimicrobial Treatment
Cystic Fibrosis
Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation
This study plans to learn more about the effect of oral antibiotics for an outpatient pulmonary exacerbation (respiratory illness) on sputum (mucus) bacterial infections, lung function, airway inflammation and quality of life.
- Trial name
- NCT02480270
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Cellulitis, Erysipelas
Duration of ANtibiotic Therapy for CEllulitis
Cellulitis is among the most common infections leading to hospitalization, yet the optimal duration of therapy remains ill defined.
- Trial name
- DANCE (NCT02032654)
- Testing
- Flucloxacillin
- Where
- 11 sites in Netherlands
- Volunteers
- 151 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Otitis Media
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
This clinical trial was conducted in a population where tympanic membrane perforation occurs in 60% infants in the first year of life.
- Trial name
- COMIT1 (NCT00539149)
- Testing
- Amoxycillin
- Where
- Australia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Bacterial Infections
Experimental Phage Therapy of Bacterial Infections
The primary purpose of this experimental therapy is to treat, with the aid of bacteriophages, patients with non-healing postoperative wounds or bone, upper respiratory tract, genital or urinary tract infections in whom extensive…
- Trial name
- NCT00945087
- Testing
- Bacteriophage preparation
- Where
- Poland
- Sponsor
- Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences
Appendicitis, Surgery
Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation
The RIPASA score is a Clinical Prediction Rule (CPR) for the diagnosis of acute appendicitis. Since its inception in 2009, the RIPASA score has been validated in various population in healthcare institutions around the world and…
- Trial name
- RIPASA-TWO (NCT03169114)
- Testing
- Amikacin Injection, Appendicectomy
- Where
- Brunei
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Raja Isteri Pengiran Anak Saleha Hospital
Acute Cholecystitis
Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy
Acute cholecystitis is frequent in the elderly, or in patients with gall stones. Most cases of severe or recurrent cholecystitis need surgery as final therapy.
- Trial name
- ACDC (NCT00447304)
- Testing
- moxifloxacin, cholecystectomy
- Where
- Germany
- Volunteers
- 644 people
- Sponsor
- Heidelberg University
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Urinary Tract Infections
INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI
Women have problems with oral antibiotics, including vagina and bowel infections. Also, bacteria causing urinary infections are becoming more resistant to oral antibiotis.
- Trial name
- INSTANT (NCT03299387)
- Testing
- Nitrofurantoin, Gentamicin
- Sponsor
- Mayo Clinic
Acute Otitis Media
Acute Otitis Media (AOM) Therapy Trial in Young Children
The purpose of this study is to learn whether or not all children with ear infections (acute otitis media or AOM) should be treated with antibiotics.
- Trial name
- NCT00377260
- Testing
- amoxicillin-clavulanate
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Pittsburgh
Infections, Bacterial
To Evaluate Plasma and Pulmonary Pharmacokinetics of GSK2140944
Antimicrobial penetration can be assessed through evaluation of antimicrobial concentrations in various lung compartments, including bronchial mucosal tissue, epithelial lining fluid (ELF), and alveolar macrophages (AM).
- Trial name
- NCT01934205
- Testing
- GSK2140944 (Single dose), GSK2140944 (Multiple dose)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Urinary Tract Infection (UTI)
The INSPIRE-ASP UTI Trial
The INSPIRE-ASP UTI trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts…
- Trial name
- NCT03697096
- Testing
- Routine Care, INSPIRE CPOE Smart Prompt
- Where
- 59 sites in United States
- Volunteers
- 55,412 people
- Sponsor
- Harvard Pilgrim Health Care
Peritoneal Dialysis-related Infection
PDRI Rates Among CAPD Patients at a Tertiary University Hospital: A 5-Year Retrospective Study
Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection rates, causative pathogens…
- Trial name
- NCT04950179
- Testing
- PDRI patients
- Where
- Thailand
- Volunteers
- 135 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Neutropenia, Febrile, Pediatric Cancer
Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study
Pediatric patients with febrile neutropenia coming to Department of Medical Oncology with low risk features (culture awaited), will be started on intravenous antibiotics (Inj Cefoperazone+ Sulbactam ± Amikacin) on outpatient…
- Trial name
- DALFEN (NCT03003273)
- Testing
- stoppage of antibiotics, amoxycillin/clavulanic acid, levofloxacin
- Where
- India
- Volunteers
- 142 people
- Sponsor
- All India Institute of Medical Sciences
Ocular Inflammation, Infection Associated Blepharitis
Antibiotic Steroid Combination Compared With Individual Administration in the in the Treatment of Ocular Inflammation and Infection
To evaluate the efficacy and safety of fixed combination of azithromycin 1.5% + 0.5% Loteprednol eye drops for the treatment of ocular inflammation and infection associated bacterial blepharitis and / or keratitis and / or…
- Conditions
- Ocular Inflammation, Infection Associated Blepharitis, Keratitis, Conjunctivitis, Bacterial
- Trial name
- NCT01721694
- Testing
- azithromycin 1.5% + Loteprednol 0,5% (separately)
- Where
- Brazil
- Sponsor
- Adapt Produtos Oftalmológicos Ltda.
Dental Plaque
Antimicrobial Photodynamic Therapy With Erythrosine and Blue Light on Dental Biofilm Bacteria
The objective of this study is to investigate the effect of Antimicrobial Photodynamic Therapy mediated by Erythrosine and blue LED in the reduction of bacteria in dental biofilm.
- Trial name
- NCT05805761
- Testing
- Conventional Treatment, Antimicrobial Photodynamic Therapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Staphylococcus (S.) Aureus Infection
Staphylococcus Aureus Caught in Action at the Site of Infection
This study is to obtain a comprehensive view of S. aureus adaptations in the infected human host and (i) to improve the understanding of the interface between antibiotic therapy, resistance development and virulence factor…
- Trial name
- PROSA (NCT04781569)
- Testing
- data collection, blood draw, nose swabs
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
SURGICAL SITE INFECTION
Early Short-term Antibiotic Therapy in Penetrating Abdominal Trauma, 3 vs 7 Days
Abdominal penetrating trauma represents a frequent cause of consult into emergency rooms in Venezuela. Accidents and violence at Hospital "Miguel Perez Carreño" along april 2009 were represented by gunshots and stabbing wounds…
- Trial name
- NCT01203046
- Testing
- Ertapenem
- Volunteers
- 56 people
- Sponsor
- Silvia M. Pinango L.
Acute Male Urinary Tract Infection
Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection
This study will investigate the treatment of urinary tract infection (UTI) in men. The investigators are looking to see if shorter duration of antibiotics (7 days) is not inferior to a longer duration of antibiotics (14 days).
- Trial name
- PROSTASHORT (NCT02424461)
- Testing
- Ceftriaxone, Ofloxacine
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Community-acquired Pneumonia (sCAP)
Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea
This study aims to provide high-level evidence for appropriate empirical antibiotic use tailored to the clinical reality in Korea by conducting a randomized controlled trial comparing monotherapy with piperacillin/tazobactam and…
- Trial name
- ACTSCAP (NCT06977347)
- Testing
- Piperacillin/Tazobactam, Piperacillin/tazobactam + Levofloxacin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- CHOSEOK YOON
Pulp Disorder
Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic
The pulp therapy in primary teeth is still necessary even with all odontopediatrics evolution in prevention and minimal intervention, aiming to keep the tooth free of inflammation or infection and in a functional state until its…
- Trial name
- NCT03839485
- Testing
- Endodontic treatment using Guedes-Pinto Paste, Endodontic using Guedes-Pinto Paste without antibiotic
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
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