Clinical trials: Antimicrobial Treatment
Acne
Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne
The purpose of the study is to determine the development of microbial resistance when using one of two topical acne therapies for the treatment of facial acne vulgaris.
- Trial name
- NCT00841776
- Testing
- Duac, Ziana gel
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Stiefel, a GSK Company
Intensive Care Unit Syndrome
Bedside Therapeutic Monitoring of β-Lactam Levels in Newborns, Children and Adolescents Admitted to Intensive Care.
This study evaluate the capacity of the MON4STRAT device for drug monitoring of β- lactam antibiotic concentrations in newborns, children, and adolescents admitted in intensive care units with a health care-associated infection.
- Trial name
- MON4STRAT (NCT03404089)
- Testing
- pharmacokinetic device
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Lille
Antibiotic
The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection.
This study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of Gram-positive bacterial infections. And optimize the dosing regimen based on these data.
- Trial name
- NCT04546815
- Testing
- Daptomycin
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jiangsu Hengrui Pharmaceutical Co., Ltd.
Periodontal Diseases, Antibiotics
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Periodontitits is a bacteria induced inflammatory disease that destroys the supporting tissues of the tooth and leads to tooth loss.
- Conditions
- Periodontal Diseases, Antibiotics, Pharmacokinetics
- Trial name
- AMA (NCT04669717)
- Testing
- 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 7 days, 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 3 days, 1/d 500 mg Azithromycine Pfizer for 3 days
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Aggressive Periodontitis, Generalized
Comparison Between Surgical Access and Repeated Applications of APDT
The aim of this study will be to compare the approach of repeated applications of APDT versus surgical therapy for the treatment of residual pockets in generalized agressive periodontitis.
- Trial name
- NCT03140059
- Testing
- Open flap debridement, Repeated application of aPDT
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Clostridium Enterocolitis, Pseudomembranous Colitis
Vancomycin vs. Nitazoxanide to Treat Recurrent C. Difficile Colitis
The purpose of this study is to compare the outcome of treatment with nitazoxanide vs. vancomycin for diarrheal disease due to Clostridium difficile in patients who have failed previous treatment with metronidazole.
- Conditions
- Clostridium Enterocolitis, Pseudomembranous Colitis, Antibiotic-Associated Colitis
- Trial name
- NCT00304889
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Intra-Abdominal Infection
T.E.A. Study Three Days Ertapenem Versus Three Days Ampicillin- Sulbactam
The aim of the study was to compare the activity (efficacy and safety) of Ertapenem administered according to a short treatment for three days versus a short treatment for three days with AS in patients with an community acquired…
- Trial name
- TEA (NCT00630513)
- Testing
- Ertapenem, Ampicillin-Sulbactam
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- University of Bologna
Helicobacter Pylori Infection
Bismuth Quadruple Therapy Versus Standard Triple Therapy
The goal of this clinical trial is to compare the standard triple therapy with Bismuth quadruple therapy in children infected with Helicobacter pylori.
- Trial name
- BismoHelP (NCT06143124)
- Testing
- Bismuth Subcitrate
- Where
- Slovenia
- Volunteers
- 216 people
- Sponsor
- University Medical Centre Ljubljana
Neonatal Infection, Neonatal SEPSIS
Reduction of Intravenous Antibiotics In Neonates
Randomized controlled open-label non-inferiority trial comparing complete intravenous antibiotic treatment with a short iv. course followed by oral antibiotics in neonates (0-28 days) with probable bacterial infection.
- Trial name
- RAIN (NCT03247920)
- Testing
- Amoxicillin Clavulanate, Antibiotics
- Where
- 18 sites in Netherlands
- Volunteers
- 510 people
- Sponsor
- Franciscus Gasthuis
Chronic Leg Ulcers, Wound Healing
Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers
Some leg ulcers do not seem to respond that well to the standard treatments that we currently use. One reason for this may be that there are high levels of bacteria in the ulcer which may be slowing down the rate of healing.
- Trial name
- NCT00825760
- Testing
- Topical PPA904 gel and light
- Where
- 4 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Photopharmica
Acute Appendicitis
Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPACIII (NCT03234296)
- Testing
- Ertapenem
- Where
- Finland
- Volunteers
- 147 people
- Sponsor
- Turku University Hospital
Respiratory Infections
Improving Antibiotic Use in Acute Care Treatment
Purpose The emergence and rapid rise in antibiotic resistance among common bacteria are adversely affecting the clinical course and health care costs of community-acquired infections.
- Trial name
- IMPAACT (NCT00144040)
- Testing
- Physician & patient education on appropriate antibiotic use, Rapid C-reactive protein testing to guide antibiotic treatment
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
Sepsis, Septic Shock
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin).
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT04991376
- Testing
- Blood-specific miRNA levels
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- University Hospital Ostrava
Blepharitis
Efficacy and Safety Study of a Steroid/Antibiotic Combination Eyedrop to Treat Non-Bacterial Blepharitis
The purpose of this study is to evaluate the clinical efficacy and safety of ISV-502 compared to AzaSite® alone, Dexamethasone alone, and vehicle in the treatment of subjects with Non-bacterial Blepharitis.
- Trial name
- DOUBle (NCT01408082)
- Testing
- ISV-502 (1.0% azithromycin and 0.1% dexamethasone combined), Azasite, Dexamethasone
- Where
- 45 sites in United States
- Volunteers
- 917 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Bacterial Conjunctivitis
Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis
The purpose of this clinical trial is to demonstrate the superiority of fusidic acid 1% over placebo in adults and children with confirmed bacterial conjunctivitis and to further establish the safety profile of fusidic acid 1%…
- Trial name
- NCT06911424
- Testing
- Fusidic Acid 1%
- Where
- 38 sites in United States
- Volunteers
- 400 people
- Sponsor
- Baxis Pharmaceuticals, Inc.
Infection
Pharmacokinetic Evaluation of Fluoroquinolone Antibiotics Administered Intravenously in Intensive Care Patients With Normal Renal Function and With Renal Hyperfiltration
At the intensive care unit (ICU) fluoroquinolone antibiotics, like levofloxacin, are frequently used for the treatment of infections. Adequate blood levels are required for a good efficacy of the antibiotic.
- Trial name
- NCT01109823
- Testing
- intravenous administration of levofloxacin
- Where
- 2 sites in Belgium
- Volunteers
- 14 people
- Sponsor
- University Ghent
Sjogren Syndrome, Xerostomia
Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome
This thesis study will investigate whether the regular use of antibacterial photodynamic therapy can alleviate dry mouth symptoms in patients with Sjogren's syndrome and thus be a potential addition to regular oral self-care…
- Trial name
- NCT06877546
- Testing
- Lumoral treatment
- Where
- Finland
- Volunteers
- 16 people
- Sponsor
- Koite Health Oy
Osteomyelitis; Vertebra
SAVE- Oral Antibiotics for Treatment of Vertebral Osteomyelitis
Background The current Danish National Guideline for treatment of pyogenic vertebral osteomyelitis (PVO) recommends 6 weeks antibiotic (AB) treatment, with a 2-week intravenous (IV) AB lead-in followed by 4 weeks oral AB for…
- Trial name
- SAVE (NCT06250023)
- Testing
- Early shift til oral antibiotic treatment for osteomyelitis
- Where
- Denmark
- Volunteers
- 530 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sinusitis
Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis
The purpose of this study is to determine the best duration(3 versus 6 weeks) of antibiotics as part of maximal medical therapy for treating chronic sinusitis and thus preventing patients from having to have sinus surgery.
- Trial name
- NCT01825408
- Testing
- Doxycycline, Azithromycin, Augmentin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Community-Acquired Infection, Cross Infection
Computerized Decision Support System for Antibiotic Treatment
We developed a computerized decision support system for prescription of antibiotics to inpatients. The purpose of the study is to assess the performance of the system in different wards, in three different hospitals, in three…
- Trial name
- NCT00233376
- Testing
- Access to an antibiotic decision support system, Distribution of local antibiotic guidelines
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Rabin Medical Center
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