Clinical trials: Antimicrobial Treatment
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cellulitis of Leg
Cellulitis Optimal Antibiotic Treatment
To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most…
- Trial name
- COAT (NCT05584007)
- Testing
- Flucloxacillin Only Product in Oral Dose Form
- Where
- United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Southampton
Critical Care, Infection
Real-world Multicentre Study of AZtreonam-AVIbactam Treatment With Infections or Suspected Infections Caused by Multidrug-resistant Gram-negative Bacteria
The AZAVI study is a multicenter observational registry (ICU and Infectious Diseases departments), designed to evaluate the real-world use of aztreonam-avibactam for suspected or documented infections caused by…
- Conditions
- Critical Care, Infection, Antibiotic Resistance, Infectious Diseases
- Trial name
- AZAVI (NCT07176247)
- Testing
- Aztreonam-Avibactam
- Where
- France
- Volunteers
- 100 people
- Sponsor
- French Society for Intensive Care
Pneumonia
Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP
Investigators will recruit patients suspected of community-acquired pneumonia at Haukeland University Hospital, Bergen, into a pragmatic randomized controlled trial to assess if provision of ultra-rapid, high-quality accurate…
- Trial name
- CAPNOR (NCT04660084)
- Testing
- Ultra-rapid molecular point-of-care testing
- Where
- Norway
- Volunteers
- 374 people
- Sponsor
- Haukeland University Hospital
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Bacterial Resistance, Infection Resistant to Multiple Drugs
SATURN 04 Nosocomial Acquisition Study
The study is the WP4 of the EU-funded (7th FW) project SATURN (Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria). A total of 6 surgical and 6 medical wards will participate in the study.
- Conditions
- Bacterial Resistance, Infection Resistant to Multiple Drugs, Staph Aureus Methicillin Resistant Colonization, Infection Due to ESBL Bacteria
- Trial name
- SATURN (NCT01208519)
- Where
- 3 sites in Italy, Romania and 1 more
- Volunteers
- 16,680 people
- Sponsor
- Catholic University of the Sacred Heart
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Helicobacter Pylori Infection
Auto Fecal Microbial Transplant Post Helicobacter Pylori Antibiotic Therapy
Current guidelines mandate Helicobacter pylori (H. Pylori) eradication with 2-3 antibiotics for 14 days ,This may result in multiple side effects and in eradication of important bacterial species to human health, exposing humans…
- Trial name
- NCT05329636
- Testing
- Fecal Microbial Transplant (FMT), Auto Fecal Microbial Transplant (FMT) via enema
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Community-acquired Pneumonia
Procalcitonin Versus C-reactive Protein to Guide Therapy in Community Acquired Pneumonia
In this study the investigators aim to test if C-reactive protein (CRP) or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht community-acquired pneumonia.
- Trial name
- CAP-Marker (NCT01018199)
- Testing
- CRP, PCT
- Where
- Brazil
- Sponsor
- Federal University of Minas Gerais
Bacterial Infections
Bacteriophage Therapy of Difficult-to-treat Infections
A retrospective, observational analysis of the first one hundred consecutive cases of bacteriophage therapy of difficult-to-treat infections, facilitated by a Belgian consortium.
- Trial name
- BT100 (NCT05498363)
- Testing
- Bacteriophage therapy
- Volunteers
- 100 people
- Sponsor
- Queen Astrid Military Hospital
Osteomyelitis
Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis
The Infectious Diseases Society of America (IDSA) 2012 guidelines for the diagnosis and treatment of diabetic foot infections state that for the treatment of diabetic foot osteomyelitis "No data support the superiority of any…
- Trial name
- CRO-OSTEO (NCT02168816)
- Testing
- Intravenous Antibacterial Agent, Oral Antibacterial Agent
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Loyola University
CF - Cystic Fibrosis, Klebsiella Pneumoniae Infection
Safety of Combined Intravenous Antibiotic and Bacteriophage Therapy in Adults With Cystic Fibrosis and Antibiotic-Resistant Lung Infections
This is a Phase 1, open-label, multi-center pilot study evaluating the safety and microbiological activity of intravenous (IV) bacteriophage therapy in combination with standard IV antibiotics in adults with cystic fibrosis (CF)…
- Conditions
- CF - Cystic Fibrosis, Klebsiella Pneumoniae Infection, E Coli Infections, Staphylococcus Aureus Infection
- Trial name
- NCT07280598
- Testing
- Intravenous Bacteriophage Cocktail plus Standard IV Antibiotics
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Febrile Neutropenia
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance
This clinical trial focuses on children with cancer who face infections after receiving chemotherapy. Chemotherapy affects the bone marrow, leading to a decrease in the production of certain white blood cells, particularly those…
- Trial name
- DAR-ARC (NCT06293677)
- Testing
- Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
The goal of this clinical trial is to learn if an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS).
- Trial name
- NCT07768267
- Testing
- Biocidin REMOVE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Heart-Assist Devices, Infections
Complications in Pediatric Mechanical Circulatory Assistance: Evaluation of Infection Management.
Heart failure is a major cause of mortality and morbidity in children. Heart transplantation can significantly improve the prognosis of patients with severe heart failure, but access is limited by a shortage of transplants.
- Conditions
- Heart-Assist Devices, Infections, Heart Transplant Infection
- Trial name
- VADINFECT (NCT06464016)
- Testing
- Ventricular Assist Device with Berlin Heart EXCOR
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Claude Bernard University
Immunoglobulin A
Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy
Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and…
- Trial name
- NCT02912520
- Testing
- Anti-Bacterial Agents
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Hemodialysis
Prophylactic Antibiotic Treatment in Hemodialysis
The purpose of this study is to assess the efficacy of prophylactic antibiotic treatment on blood stream infections and severe culture negative infections, in patients on newly started hemodialysis(HD), with a central venous…
- Trial name
- PANTHEM (NCT05248620)
- Where
- 7 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Infectious Diseases, Respiratory Tract Infections
Safety of Discontinuing Patient Antibiotic Treatment
There is no evidence that discontinuing antibiotic therapy for non-bacterial infections is safe. The main objective of this study is to determine whether discontinuation of antibiotic therapy when a clinician no longer considers…
- Trial name
- STOP-AB (NCT02900820)
- Testing
- Discontinuing antibiotic therapy, Continuing antibiotic therapy
- Where
- 5 sites in Spain
- Volunteers
- 430 people
- Sponsor
- Spanish Society of Family and Community Medicine
Community-acquired Pneumonia
Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia
The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with community-acquired pneumonia.
- Trial name
- BICAP (NCT00818610)
- Testing
- Beta lactam (amoxicillin / clav. acid OR cefuroxime), Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
- Where
- 6 sites in Switzerland
- Volunteers
- 601 people
- Sponsor
- Swiss National Fund for Scientific Research
Pneumonia
Hospitalised Pneumonia With Extended Treatment (HOPE) Study
An intervention study to determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia
- Trial name
- HOPE (NCT02783859)
- Testing
- Amoxicillin-clavulanic Acid
- Where
- 5 sites in Australia, Malaysia and 1 more
- Volunteers
- 314 people
- Sponsor
- Menzies School of Health Research
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