Clinical trials: Antimicrobial Treatment
Population Modeling of Anti-infective Drugs
Translational PKPD Modeling of Anti-infective Drugs Used in Pediatric Units.
Pharmacokinetic and pharmacodynamic modeling (PKPD) is becoming an essential tool for optimizing pharmacotherapy. Building mechanistic models allows determining the relationship between the dose, concentration, pharmacological…
- Trial name
- NCT05426499
- Testing
- Patients requiring cefotaxime treatment, Patients requiring meropenem treatment, Patients requiring fluconazole treatment
- Where
- 4 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Poznan University of Medical Sciences
Infection, Pneumonia
To Evaluate the Treatment Effect of an Anti-Infective Agent for Different Kinds of Infections (0826-052)
To collect clinical response data with the use of ertapenem in approved indications.
- Conditions
- Infection, Pneumonia, Urinary Tract Infection
- Trial name
- NCT00398099
- Testing
- MK0826, ertapenem sodium / Duration of Treatment: 14 Days
- Volunteers
- 30 people
- Sponsor
- Merck Sharp & Dohme LLC
Urinary Tract Infections, Bacteremia
Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs
To evaluate if the combination of pivmecillinam and clavulanic acid (PAC) is non-inferior to ciprofloxacin, trimethoprim-sulfamethoxazole or ertapenem as step down oral therapy in patients with febrile UTI caused by extended…
- Conditions
- Urinary Tract Infections, Bacteremia, Antibiotic Resistant Infection
- Trial name
- PACUTI (NCT05224401)
- Testing
- Pivmecillinam and amoxicillin/clavulanic acid, Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility
- Where
- 5 sites in Sweden
- Volunteers
- 330 people
- Sponsor
- Lund University
Bacterial Infection With One or More Extended Spectrum Betalactamases Remaining Susceptible to Temocillin
Study of Adverse Effects Occuring in Patients Receiving an Antibiotic Treatment With Temocillin
The Temocillin prescription frequency may be increased in order to reduce the use of carbapenems to reduce the progressive increase in carbapenem resistance observed in recent years.
- Trial name
- Témocilline (NCT03599999)
- Testing
- Adverse events detection
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Periodontal Disease
Periodontal Disease Treatment of a Physically Challenged Population
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush.
- Trial name
- PDT (NCT01718912)
- Testing
- metronidazole-nystatin oral rinse
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oravital Inc
Bacterial Infections
Evaluation of the Artificial Intelligence-based Prescription Support Software iAST® for the Choice of Empirical and Semi-targeted Antibiotic Treatment
Inadequate treatment of infections frequently leads to complications that cause new visits to the doctor, lengthen hospital stays and can lead to sepsis, even causing the death of affected patients.
- Trial name
- EVIAST (NCT06174519)
- Testing
- Medical device simulation
- Where
- Spain
- Volunteers
- 325 people
- Sponsor
- Pragmatech AI Solutions
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Invasive Fungal Infections, Invasive Bacterial Infection
PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised.
We seek to characterise the burden and outcomes of and understand the current experience of people who inject drugs admitted to hospital with invasive injecting-related infections, in order to implement and evaluate strategies to…
- Conditions
- Invasive Fungal Infections, Invasive Bacterial Infection, Injection Site Infection, Infection, Bacterial
- Trial name
- PATH (NCT06220370)
- Testing
- Observational
- Volunteers
- 300 people
- Sponsor
- Kirby Institute
Pneumonia, Bronchopneumonia
Duration of Antibiotic Therapy in Community - Acquired Pneumonia
The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject's clinical response compared to a local standard approach in patients coming from the…
- Conditions
- Pneumonia, Bronchopneumonia, Pleuropneumonia, Pneumonia, Bacterial
- Trial name
- DURATION (NCT01492387)
- Testing
- Discontinuation of antibiotic therapy
- Where
- 15 sites in Italy
- Volunteers
- 892 people
- Sponsor
- University of Milan
Appendicitis
TRIAD Appendicitis Decision-making Surveys
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative.
- Trial name
- TRIAD (NCT05887414)
- Testing
- Baseline, 30 Day Follow Up
- Where
- 17 sites in United States
- Volunteers
- 2,542 people
- Sponsor
- University of Washington
Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit
Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock
The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated…
- Trial name
- SSS (NCT02473263)
- Testing
- Ceftriaxone, Piperacillin tazobactam, Norepinephrine
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart-Assist Devices, Infections
Complications in Pediatric Mechanical Circulatory Assistance: Evaluation of Infection Management.
Heart failure is a major cause of mortality and morbidity in children. Heart transplantation can significantly improve the prognosis of patients with severe heart failure, but access is limited by a shortage of transplants.
- Conditions
- Heart-Assist Devices, Infections, Heart Transplant Infection
- Trial name
- VADINFECT (NCT06464016)
- Testing
- Ventricular Assist Device with Berlin Heart EXCOR
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Claude Bernard University
Periodontitis, Periodontal Diseases
The Influence of Local Antibiotic Therapy on the Outcomes Following Periodontal Regeneration Procedures.
Assessmnet of the influence of local antibiotic therapy on the clinical, radiological, microbiological parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) following periodontal regeneration…
- Trial name
- ANBperio (NCT07027137)
- Testing
- SRP+ANB+SURG, SRP+SURG
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Periodontitis, Halitosis
Adjunctive Effect of Photodynamic Therapy on Halitosis
The present study aims to evaluate bad breath in patients undergoing gingival treatment combined with tongue scraping and laser and to assess its potential benefits for both periodontal and microbiological condition.
- Trial name
- NCT06764342
- Testing
- Full-mouth scaling combined with antimicrobial photodynamic therapy, full-mouth scaling
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Pulmonary Sepsis
Personalized Optimization of Antibiotic Therapy in Pulmonary Sepsis Critically Ill Patients Through Application of Rapid Microbiological Diagnostic Technologies and Pharmacokinetic/Pharmacodynamic Modelling
Severe community-acquired and nosocomial pneumonia are associated with substantial morbidity and mortality. Early and appropriate antimicrobial therapy (AAT) is consistently the most effective intervention for reducing mortality.
- Trial name
- IDAST (NCT06956053)
- Testing
- Rapid ID/AST method, Conventional biological methods
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Urinary Tract Infections
Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).
- Trial name
- NCT00084201
- Testing
- Cranberry juice, Amoxicillin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Primary IgA Nephropathy
Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis in the world.There is to date no curative therapy for patients with IgAN.It is considered that dendritic cells, Toll-like receptor (TLR) 9 and…
- Trial name
- HCQIgAN (NCT02765594)
- Testing
- Hydroxychloroquine Sulfate, Valsartan
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Peking Union Medical College Hospital
Peri Implant Mucositis, Dental Implant Rehabilitation
Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses
The goal of this clinical trial is to learn whether a home-use light device helps control gum inflammation around dental implants in adults who have a full set of fixed teeth attached to implants.
- Conditions
- Peri Implant Mucositis, Dental Implant Rehabilitation, Prosthesis and Implant Dentistry, Implant Supported Prosthesis
- Trial name
- NCT07763431
- Testing
- Dual-light antibacterial photodynamic therapy, Supportive peri-implant care
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Infection, Sepsis
KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill Patients
The study aims to compare the efficacy and safety of an absolute procalcitonin (PCT) value-guided antibiotic initiation protocol and a protocol using the kinetics of PCT (the difference between the actual and the previous day…
- Trial name
- KIPRUN (NCT07211620)
- Testing
- Kinetics, Absolute
- Where
- 2 sites in Hungary
- Volunteers
- 250 people
- Sponsor
- Semmelweis University
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