Clinical trials: Antimicrobial Treatment
Periodontitis, Chronic, Periodontal Diseases
Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions
The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.
- Conditions
- Periodontitis, Chronic, Periodontal Diseases, Periodontal Bone Loss
- Trial name
- NCT03264118
- Testing
- Scaling and root planing, Toluidine Blue O
- Where
- 2 sites in Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo
Medication Adherence
Antibiotic Adherence Practices in Dermatologic Surgery
This multi-center prospective observational cohort study will examine the prevalence of non-adherence along with analyze the risk factors of non-adherence for patients presenting to dermatologic surgery.
- Trial name
- NCT04117724
- Testing
- Survey
- Where
- 9 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Substance Use Disorders, Infection, Soft Tissue
Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use
Standard of care for patients with opioid use disorder and complicated infections is discharge to subacute nursing facilities on IV antibiotics until completion of treatment course.
- Conditions
- Substance Use Disorders, Infection, Soft Tissue, Bacteremia, Osteomyelitis Acute
- Trial name
- AIM-STOP (NCT05521880)
- Testing
- Oritavancin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Maryland, Baltimore
Influenza, Human
A Study of Intravenous Zanamivir Versus Oral Oseltamivir in Adults and Adolescents Hospitalized With Influenza
The purpose of this study is to test the safety and efficacy of zanamivir given intravenously and how well it works at two different doses in hospitalized adolescents and adults with flu.
- Trial name
- ZORO (NCT01231620)
- Testing
- Zanamivir, Oseltamivir
- Where
- 170 sites in United States, Australia and 26 more
- Volunteers
- 626 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
Full Mouth Disinfection and Antibiotics for Periodontitis in High or Moderate Disease Activity Rheumatoid Arthritis
The purpose of this study is to determine whether full mouth disinfection in combination with one week antibiotic amoxicillin plus metronidazole antibiotic therapy is improving periodontitis and disease activity of rheumatoid…
- Trial name
- FMD-ABRA (NCT02096120)
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Urinary Tract Infections, Pediatric Disorder
Assessment of the Efficacy on the 5th Day of Antibiotic Therapy for Febrile Urinary Tract Infections Among Children From 3 Months to 18 Years Old
The main objective is to describe the rate of asymptomatic patients after 5 days of effective antibiotic therapy in an uncomplicated febrile urinary tract infection in children between 3 months and 18 years of age.
- Trial name
- PEDIU5 (NCT04667546)
- Testing
- Survey
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Infection, Pneumonia
A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)
The primary objective of this study is a comparison between MK0787B and standard therapy.
- Trial name
- NCT00445094
- Testing
- MK0787B, imipenem/cilastatin sodium / Duration of Treatment: 7 Days, Comparator: amikacin / Duration of Treatment: 3 Days, Comparator: tazocin / Duration of Treatment: 3 Days
- Volunteers
- 120 people
- Sponsor
- Merck Sharp & Dohme LLC
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland
Scrub Typhus
Scrub Typhus Antibiotic Resistance Trial
Study type: Randomized Control Treatment Trial Study population: Male and female patients with ≥15 years of age and acute scrub typhus Duration: 2 years Study Design: Prospective, open-label, randomized-controlled treatment trial…
- Trial name
- START (NCT03083197)
- Testing
- Doxycycline 7 days, Doxycycline 3 days, Azithromycin 3 days
- Where
- 5 sites in Thailand
- Volunteers
- 177 people
- Sponsor
- University of Oxford
Multiple Erythema Migrans
Antibiotic Treatment of Multiple Erythema Migrans
The purpose of this study is to compare the efficacy and safety of 15-day ceftriaxone versus 15-day doxycycline treatment in patients with multiple erythema migrans.
- Trial name
- NCT01163994
- Testing
- ceftriaxone, doxycycline, erythema migrans patients treated with doxycycline
- Where
- Slovenia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Severe Sepsis
Study of Procalcitonin (PCT)-Guided Antibiotic Use in Severe Sepsis Patients Without Obvious Infection
A recent study has demonstrated that in low respiratory infections, a strategy using prescription of antibiotics based on the pro-calcitonin level allows decreasing recourse to antibiotics by 47% without prognostic modification.
- Trial name
- Pro-SEPS (NCT01025180)
- Testing
- Procalcitonin level
- Where
- 9 sites in France
- Volunteers
- 62 people
- Sponsor
- Brahms France
Cystic Fibrosis
Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
The aim of this study is to investigate the efficacy of antibiotic therapy with any antibiotic (IV) and IV (Nebcin®) tobramycin for 5 days followed by Solution for nebuliser inhalation (Tobi®) for 9 days and antibiotic cures…
- Trial name
- TOBRAMUC (NCT03066453)
- Testing
- Tobi Inhalant Product, Nebcin
- Where
- 7 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Staphylococcal Bacteraemia
DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia
This is a Phase 2b clinical study, multicenter, randomized, open-label, assessor-blinded, superiority study. The study will compare dalbavancin to standard of care antibiotic therapy for the completion of therapy in patients with…
- Trial name
- NCT04775953
- Testing
- Cefazolin, Dalbavancin, Daptomycin
- Where
- 24 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pressure Injury, Venous Leg Ulcer
Pivotal Study of an Antimicrobial Wound Dressing to Treat Chronic Wounds
The goal of this clinical trial is to assess the impact that the NanoSALV wound dressing can have on managing severe chronic wounds and feasibility for patients, providers, and health systems in different health care settings…
- Conditions
- Pressure Injury, Venous Leg Ulcer, Pressure Injury Stage 2, Pressure Injury Stage III
- Trial name
- NCT05619237
- Testing
- NanoSALV Catalytic
- Where
- 4 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Chester Ho, MD
Cystic Fibrosis
Longitudinal Analysis of Respiratory and Intestinal Microbiome in Cystic Fibrosis
Respiratory und intestinal microbiome will bei analyzed during a period of 6 months. In a retrospective analysis it will be looked for correlations between microbiome and cf therapy (e.g.
- Trial name
- NCT03335202
- Testing
- analysis of microbiome
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Kiel
Small Intestinal Bacterial Overgrowth
Antibiotic Treatment Trial for Small Intestinal Bacterial Overgrowth
This is a randomized, double-blind, placebo-controlled study to evaluate the efficacy of ciprofloxacin versus metronidazole versus placebo in eradication of small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT02458781
- Testing
- Metronidazole, Ciprofloxacin
- Volunteers
- 180 people
- Sponsor
- San Antonio Military Medical Center
UTI - Lower Urinary Tract Infection, Antibiotic Resistant Infection
Efficacy of Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infection (uUTI)
This is a prospective, Phase 4, open label, multi-center study of the clinical and microbiologic efficacy of ciprofloxacin for the treatment of uncomplicated urinary tract infections in adult women.
- Trial name
- NCT03366207
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Iterum Therapeutics, International Limited
Endocarditis, Bacterial
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis
Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis.
- Trial name
- SATIE (NCT04222257)
- Testing
- Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Carmen Olmos Blanco
Puerperal Infection
Prophylactic Antibiotic After Perineal Tear
Current World Health Organization guidelines recommend routine antibiotic prophylaxis for women with perineal tear 3rd and 4th degree but not for 2nd degree because of insufficient evidence of effectiveness.
- Trial name
- PATPET (NCT04763486)
- Testing
- Cefazolin (Cefamezin)
- Where
- Israel
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
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