Clinical trials: Antipsychotic
Schizophrenia
The Danish Region Midt Schizophrenia Cohort
The objective of this study is to recruit patients at the first diagnosis with a schizophrenia spectrum disorder (SSD) and ultra-high risk patients (UHR), defined as patients with drug abuse and psychotic symptoms indicating a…
- Trial name
- RMS (NCT06431009)
- Testing
- Treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 350 people
- Sponsor
- University of Aarhus
Neurodevelopmental Disorders, Irritability
AP Metabolism Transcriptomics
It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear…
- Trial name
- NCT06814314
- Testing
- Transcriptomic investigation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Schizophrenia
A Study of Paliperidone Enantiomer Disposition With Different Formulations and the Bioavailability of Immediate- and Extended-release Paliperidone
The purpose of this study is to characterize the pharmacokinetics of paliperidone in plasma and urine after intravenous (i.v.) administration of the racemate, administration of the immediate-release (IR) racemate oral solution…
- Trial name
- NCT00796276
- Testing
- IR OROS paliperidone and ER OROS paliperidone
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia, Dual Diagnosis
Alcoholism and Schizophrenia: Effects of Clozapine
The purpose of this study is to examine the short - term effects of clozapine on alcohol use in persons with schizophrenia and an alcohol use disorder.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00169026
- Testing
- Clozapine versus typical (conventional) and atypical antipsychotic medications
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Bipolar Disorder
Efficacy and Safety of Psychopharmacotherapy in Patients With Schizophrenia or Bipolar Disorders
The purpose of this study is to investigate the efficacy and safety of long-term psychopharmacotherapy in schizophrenia or bipolar disorder in terms of psychopathology and side effects.
- Trial name
- NCT00330226
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Alzheimer Disease, Dementia Alzheimers
An Electronic Clinical Decision Support Tool to Reduce Low-value Antipsychotic Prescriptions
The goal of this study will be to design, implement and test the impact of a quality improvement (QI) intervention that uses an EHR CDS tool among physicians newly ordering an antipsychotic medication for older adults with ADRD.
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT04851691
- Testing
- EHR CDS, Usual Care
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of California, Los Angeles
Schizophrenia, Psychotic Disorders
A Study of the Effectiveness and Safety of Risperidone Compared With Haloperidol and Placebo in Patients With Chronic Schizophrenia
The purpose of the study is to evaluate the effectiveness and safety of different doses of risperidone (an antipsychotic medication) compared with placebo and with a fixed 20 mg/day dose of a standard antipsychotic, haloperidol…
- Trial name
- NCT00249132
- Testing
- risperidone
- Volunteers
- 523 people
- Sponsor
- Janssen, LP
Unipolar Depression
The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression
Recently published work has examined the effects of "atypical antipsychotics" in SSRI-treatment resistant patients. In these studies, patients with unipolar depression who were treated with SSRI's, but not responsive to treatment…
- Trial name
- NCT00517387
- Testing
- Quetiapine XR
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Schizophrenia
Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics
The purpose of this study is to understand, with the use of functional magnetic resonance imaging, the neural correlates involved in appetite control and the mechanism of weight gain in patients with schizophrenia treated with…
- Trial name
- NCT00290121
- Testing
- Olanzapine
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Schizophrenia, Schizoaffective Disorder
Research Into Antipsychotic Discontinuation and Reduction Trial
Psychosis and schizophrenia are common and costly mental health problems. Psychosis is the name given to a group of mental conditions in which cause people to perceive or interpret things differently from those around them.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Delusional Disorder, Schizophreniform Disorders
- Trial name
- NCT03559426
- Testing
- Antipsychotic Reduction, Antipsychotic Maintenance
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- University College, London
Schizophrenia
Efficacy of Selegiline in Negative Symptoms of Schizophrenia
Antipsychotic drugs are effective in treating the positive symptoms of schizophrenia; however their efficacy in treating negative symptoms is limited.
- Trial name
- NCT00456976
- Testing
- Selegiline
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Tabriz University
Schizophrenia
A Study of the Efficacy (Effectiveness) of Paliperidone Palmitate in the Prevention of Recurrence of the Symptoms of Schizophrenia.
The purpose of this study is to evaluate the efficacy of paliperidone palmitate compared with placebo in the prevention of recurrence of the symptoms of schizophrenia and to assess the safety and tolerability of paliperidone…
- Trial name
- NCT00111189
- Testing
- Paliperidone Palmitate
- Where
- 55 sites in United States, Costa Rica and 7 more
- Volunteers
- 414 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Tardive Dyskinesia
Xenazine in Late Dyskinetic Syndrome With Neuroleptics
Late dyskinetic syndrome with neuroleptics, or tardive dyskinesia, is the appearance of abnormal involuntary movements (AIM) in patients treated with antipsychotics for at least three months.
- Trial name
- Xeladys (NCT01543321)
- Testing
- Tetrabenazine
- Where
- 19 sites in France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Schizophrenia
A Bioequivalence Study of 15 mg ER OROS Paliperidone
The purpose of this study is to evaluate the bioequivalence between the Phase 3 and the to-be-marketed formulations of extended release (ER) OROS paliperidone and to evaluate the effect of food on the highest to be marketed…
- Trial name
- NCT00892489
- Testing
- ER OROS Paliperidone
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depression, Affective Disorders, Psychotic
Routine Plasma Level Determination to Compare Actual vs Expected Plasma Levels at Psychiatric Inpatient Admission
Compliance with treatment is notoriously low in psychiatric patients. Traditional methods of monitoring compliance, however, may underreport nonadherence to treatment.
- Trial name
- NCT00627510
- Testing
- Routine psychiatric inpatient treatment
- Where
- Austria
- Volunteers
- 161 people
- Sponsor
- Medical University Innsbruck