Clinical trials: Antiretroviral Therapy
HIV Infection
Antiretroviral-Sparing Concept With HIV-specific T Cell Precursors With High Proliferative Capacity (PHPC)
PHPC-02 is a phase II, randomized, placebo-controlled trial designed to investigate whether therapeutic immunization during highly active antiretroviral therapy (HAART) induces elevations of HIV-specific T cell precursors with…
- Trial name
- PHPC-02 (NCT00918840)
- Testing
- DermaVir, HAART
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Genetic Immunity
HIV-1 Infection
Study to Evaluate the Safety and Efficacy of a Single Tablet Regimen of Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate Compared With a Single Tablet Regimen of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naive Adults
The purpose of the study was to evaluate the safety and efficacy of the emtricitabine (FTC)/rilpivirine (RPV)/tenofovir disoproxil fumarate (TDF) single-tablet regimen (STR) compared with the efavirenz (EFV)/FTC/TDF STR in HIV-1…
- Trial name
- NCT01309243
- Testing
- FTC/RPV/TDF, EFV/FTC/TDF
- Where
- 151 sites in United States, Australia and 12 more
- Volunteers
- 799 people
- Sponsor
- Gilead Sciences
HIV Infection
Aspirin and Antiretroviral Therapy in HIV Infected Patients
The purpose of this study is to examine the effects of HIV treatment (antiretroviral therapy) and aspirin use on risk for cardiovascular disease among HIV infected persons.
- Trial name
- NCT00783614
- Testing
- Aspirin 325mg, Antiretroviral therapy (ART)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Hennepin Healthcare Research Institute
Neoplasms, Tumors
Laboratory-Treated Autologous Lymphocytes, Aldesleukin, and Sargramostim (GM-CSF) in Treating Advanced Solid Tumors
RATIONALE: Giving autologous lymphocytes that have been treated in the laboratory with antibodies may stimulate the immune system to kill tumor cells. Aldesleukin may stimulate the lymphocytes to kill tumor cells.
- Conditions
- Neoplasms, Tumors, Solid Tumors, Metastatic Cancer
- Trial name
- NCT01081808
- Testing
- EGFRBi-armed autologous activated T cells
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Roger Williams Medical Center
HIV Infection, Adherence
Social Norms and Priming to Improve Adherence to Antiretroviral Therapy and Retention in Care
Interventions incorporating constructs from behavioral economics and psychology have the potential to enhance HIV 'treatment as prevention' (TasP) strategies.
- Trial name
- NCT02938533
- Testing
- Intervention
- Where
- 2 sites in Tanzania
- Volunteers
- 438 people
- Sponsor
- University of California, Berkeley
HIV Infection
Safety and Efficacy of a Switch to Doravirine/Islatravir in Participants With HIV-1 (MK-8591A-017)
This study will evaluate the safety and efficacy of a switch to MK-8591A (a fixed dose combination of doravirine and islatravir) in human immunodeficiency virus -1 (HIV-1)-infected participants virologically suppressed on a…
- Trial name
- NCT04223778
- Testing
- DOR/ISL, ART
- Where
- 78 sites in United States, Australia and 13 more
- Volunteers
- 672 people
- Sponsor
- Merck Sharp & Dohme LLC
Bone Loss
BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study
The primarily objective of this study is to assess the effect of switching from Tenofovir Disoproxil Fumurate (TDF) to TAF based ART on bone mass and turnover among women on DMPA for contraception.
- Trial name
- BONE:STAR (NCT03916328)
- Testing
- B/F/TAF, TDF/3TC/EFV or DTG or NVP, DMPA
- Where
- Uganda
- Volunteers
- 330 people
- Sponsor
- MU-JHU CARE
HIV, Community Health Workers
The Impact of Home Delivery of Antiretroviral Therapy on Virological Suppression
Home delivery of antiretroviral therapy (ART) by community health workers (CHWs) has the potential to reduce key barriers to ART care retention.
- Conditions
- HIV, Community Health Workers, Antiretroviral Therapy, Highly Active
- Trial name
- NCT02711293
- Testing
- ART home delivery, Enhanced nutrition counseling
- Where
- Tanzania
- Volunteers
- 2,172 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV Infections
A Comparison of Two Ways to Manage Anti-HIV Treatment (The SMART Study)
The purpose of this study is to compare two ways of using anti-HIV drugs to help health care providers and patients decide how to best use anti-HIV treatments over many years.
- Trial name
- NCT00027352
- Where
- 223 sites in United States, Argentina and 24 more
- Volunteers
- 6,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load
The purpose of this study is to determine if HIV-specific canarypox vaccine and/or interleukin-2 (IL-2) will control viral load (amount of HIV in the blood) after HIV treatment is withdrawn for a certain time period.
- Trial name
- NCT00013663
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), Aldesleukin
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
Pilot Test of a Couple-Based Medication Adherence Intervention for HIV-Positive Women and Their Male Partners in South Africa
The purpose of this study is to collect quantitative data related to developing and testing a couple-based intervention (CBI) for HIV-positive women's medication adherence in the region of Kwazulu-Natal, South Africa.
- Trial name
- NCT03809364
- Testing
- START Together
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- University of Maryland, College Park
HIV Care Loss to Followup, HIV Antiretroviral Therapy (ART) Adherence
Developing and Testing a Digital Health Tool for INterseCtional Stigma Assessment and Reduction at Multiple Levels and mUltiple DimEnsions (INCLUDE) to Improve HIV Care in ART Centers in Nepal
People living with HIV (PLWH) have poor clinical outcomes when they are excluded from care due to intersectional stigma related to HIV, mental health (MH), and other dimensions.
- Conditions
- HIV Care Loss to Followup, HIV Antiretroviral Therapy (ART) Adherence, HIV Stigma, Mental Health Conditions
- Trial name
- INCLUDE (NCT07370298)
- Testing
- INCLUDE
- Where
- Nepal
- Volunteers
- 88 people
- Sponsor
- Possible
HIV Infections, Acquired Immunodeficiency Syndrome
Safety and Efficacy of an Investigational Drug in Human Immunodeficiency Virus (HIV)-Infected Patients Failing Current Antiretroviral Therapies (0518-005)(COMPLETED)
This study will investigate the safety and efficacy of different doses of an investigational drug (MK0518) as a therapy for HIV-infected patients failing current antiretroviral therapies.
- Trial name
- NCT00105157
- Testing
- Comparator: MK0518, MK0518
- Volunteers
- 179 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children
The primary objective of this study is to assess the efficacy of switching to tenofovir disoproxil fumarate (TDF) compared to continuing stavudine or zidovudine in maintaining virologic suppression in HIV-1 infected children.
- Trial name
- NCT00528957
- Testing
- Tenofovir DF, Zidovudine, Stavudine
- Where
- 9 sites in United States, Panama and 1 more
- Volunteers
- 97 people
- Sponsor
- Gilead Sciences
Hyperlipidemia, HIV Infections
Rosuvastatin Versus Pravastatin in HIV Patients Treated With Boosted Protease Inhibitors (PI) (ANRS126)
In HIV hypercholesterolemic patients treated with protease inhibitors, some drugs of the statin group are used to control cholesterol level.
- Trial name
- NCT00117494
- Testing
- Pravastatin, Rosuvastatin
- Where
- France
- Volunteers
- 86 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
Evaluating the Safety and Antiviral Activity of Monoclonal Antibody VRC01 in Infants With HIV Receiving Combination Antiretroviral Therapy
The purpose of this study was to evaluate the safety and antiviral activity to promote clearance of HIV-1 infected cells of VRC01 in infants with HIV beginning combination antiretroviral therapy (cART).
- Trial name
- NCT03208231
- Testing
- VRC01, Combination Antiretroviral Therapy (cART)
- Where
- 7 sites in Botswana, Brazil and 2 more
- Volunteers
- 61 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Tuberculosis
Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in Vietnam
The overall aim of the project is to evaluate rifabutin (RBT) as a replacement for rifampicin (RMP), for the combined treatment of tuberculosis and HIV infection.
- Trial name
- NCT00651066
- Testing
- rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 1, rifabutin in combination with lopinavir boosted by ritonavir - dosing schedule 2
- Where
- Vietnam
- Volunteers
- 47 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
Effect of Nutritional Intervention on the Lipid Profile of HIV-Positive Patients Who Start HAART: a Randomized Trial
Highly active antiretroviral therapy (HAART) in HIV-positive patients is associated with the development of dyslipidemia, a risk factor for cardiovascular events.
- Trial name
- NCT00429845
- Testing
- Nutritional
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
HIV Testing Rate, Acceptance of Immediate ART
Thai MSM/TG Test and Treat Study
Objectives 1. To determine the uptake of universal HIV testing among Thai men who have sex with men (MSM) and transgender women (TG) 2.
- Trial name
- NCT01869595
- Where
- Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Antiretroviral Treatment Outcomes
Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression
The HIV/AIDS pandemic remains among the investigators greatest public health challenges. In the absence of an effective vaccine, focus has shifted to other prevention strategies such as pre-exposure prophylaxis.
- Trial name
- TOAST (NCT01387022)
- Testing
- Tenofovir, lamivudine and efavirenz
- Where
- South Africa
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
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