Clinical trials: Anxiety Depression Disorder
Major Depressive Disorder, Anxiety Disorders
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration
The current study will test the causal relationship between elevated levels of cortisol and the serotonin transporter gene (5-HTTLPR) as these factors influence sensitivity to environmental threat.
- Trial name
- 5-HTTLPR (NCT01710202)
- Testing
- Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Schizophrenia, Depression
Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses
This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses.
- Conditions
- Schizophrenia, Depression, Bipolar Disorder, Anxiety Disorders
- Trial name
- NCT00458094
- Testing
- Physical activity intervention with peer support (PA+PS), Physical activity intervention without peer support (PA)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Artificial Intelligence (AI), Depression - Major Depressive Disorder
Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress
Emotional Distress, such as anxiety and depression, is an essential issue worldwide. There have been several evidence-based psychotherapies that are effective in improving emotional distress, such as Acceptance and Commitment…
- Conditions
- Artificial Intelligence (AI), Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT06735807
- Testing
- Generated AI-based intervention (Emohaa), group ACT, wailist (delayed intervenion)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central University of Finance and Economics, China
Domestic Violence, Depression
Cortisol Evaluation in Abuse Survivors
This study looks at the biological effect of domestic violence and abuse (DVA) on women's mental health. The mechanisms through which DVA causes mental disorders are very poorly understood.
- Conditions
- Domestic Violence, Depression, Anxiety, Panic Disorder
- Trial name
- CEASE (NCT01632553)
- Where
- 2 sites in United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Bristol
Major Depression, Generalized Anxiety Disorder
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines
The hypothesis of this study is that symptoms of anxiety, depression and insomnia; and indices of psychosocial function will all improve, while BZ use will decrease significantly during a twelve-week trial period of substituting…
- Trial name
- NCT01244711
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Overweight, Obesity
Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
The Fit2Play prospective cohort study examines the effects of a park-based youth physical activity afterschool program on youth participant fitness and mental health outcomes.
- Conditions
- Overweight, Obesity, Hypertension, Prehypertension
- Trial name
- F2P (NCT06595251)
- Testing
- Fit2Play curriculum
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression in Adolescence, Depression in Adults
INNOV5-MH-MAROC: Integrated Mental Health Care for Adolescents and Adults in Primary Care Centers and Schools in Morocco
Depression and anxiety are highly prevalent among adolescents and adults in Morocco, while access to evidence-based care in primary care centers and schools remains limited.
- Conditions
- Depression in Adolescence, Depression in Adults, Anxiety, Mental and Behavioural Disorders
- Trial name
- INNOV5-MH (NCT07258095)
- Testing
- INNOV5 Integrated Mental Health Program, Enhanced Treatment as Usual (TAU+)
- Where
- Switzerland
- Volunteers
- 146 people
- Sponsor
- Swiss Medical Academy Maroc
Depression, Anxiety
A Gratitude Intervention App to Reduce Symptoms of Depression, Anxiety and Stress
The goal of this clinical trial is to examine whether a newly developed gratitude intervention app can effectively improve psychological functioning, as measured by depression, anxiety, and stress symptoms, positive and negative…
- Conditions
- Depression, Anxiety, Stress
- Trial name
- NCT06621745
- Testing
- Gratitude Intervention App
- Where
- Canada
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Chronic Pain, Migraine Disability
Chronic Pain in the General Population of Chile
The present study seeks to follow up the cohort of adults representative of Chile's urban population whose levels of chronic pain were evaluated in March 2023 (baseline) as part of the Mental Health Thermometer (MHT) study.
- Conditions
- Chronic Pain, Migraine Disability, Neuropathic Pain, Fibromyalgia
- Trial name
- RDC (NCT06353100)
- Where
- Chile
- Volunteers
- 2,365 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Delirium, Anxiety and Depression
Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit
Artificial intelligence (AI), now an integral part of healthcare services and presents numerous opportunities. Customized treatment plans, clinical decision support systems, predictive analysis for disease prevention, patient…
- Conditions
- Delirium, Anxiety and Depression, Intensive Care Units (ICUs), Artificial Intelligence (AI)
- Trial name
- AINURSE-OP (NCT07171944)
- Testing
- Structured orientation program, Human Nurse
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Koç University
Depressive Disorders, Anxiety Disorders
Stress, Anxiety, and Mood Group Therapy
The purpose of this study is to identify cognitive mechanisms that might facilitate treatment response for individuals experiencing depression and/or anxiety.
- Trial name
- NCT03855683
- Testing
- Unified Protocol for The Treatment of Emotional Disorders
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Palo Alto University
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
End of Life, Pain
Virtual Reality at End-of-life
The purpose of this research is to determine the effect that repeated, personalized virtual reality experiences have on symptom severity, comparing self-reported symptom severity both pre and post each session, and overtime…
- Conditions
- End of Life, Pain, Nausea, Fatigue
- Trial name
- NCT06149429
- Testing
- Personalized virtual reality experience
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- State University of New York at Buffalo
Angling, Supportive Therapeutic
Investigation of the Effects of Angling as Supportive Therapy in Schizophrenia Treatment on Serum Parameters, Anxiety, Depression, and Quality of Life
This study aims to evaluate the effects of recreational fishing (angling) as a supportive therapeutic intervention in individuals diagnosed with schizophrenia.
- Conditions
- Angling, Supportive Therapeutic, Schizophrenia
- Trial name
- NCT07682935
- Testing
- recreational fishing (angling)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without…
- Trial name
- NCT07065240
- Testing
- SPT-300
- Where
- 61 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Seaport Therapeutics
Anxiety, Depression
Mindfulness-based Cognitive Therapy to Improve Emotional Wellbeing and Glycaemic Control in Diabetes
Type 1 and 2 diabetes are challenging conditions to manage. Anxiety and depression are common among this group and are associated with poorer diabetes control.
- Conditions
- Anxiety, Depression, Diabetes
- Trial name
- MILESTONE (NCT02600091)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Aberdeen
Autism, Autism Spectrum Disorder
The Supplementation Therapy in Autism and Response to Treatment Study
In addition to the "core" symptoms of ASD (i.e., impaired communication, impaired reciprocal social interaction and restricted, repetitive and stereotyped patterns of behaviors or interests), it is estimated that up to 70% of…
- Conditions
- Autism, Autism Spectrum Disorder, Autism Spectrum Disorder High-Functioning, Asperger Syndrome
- Trial name
- START (NCT06187090)
- Testing
- Oral Ultramicronized-Palmitoylethanolamide (um-PEA; 600 mg per day) in tablet form
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Udine
Arthropathy, Anxiety
Virtual Reality in Orthopedic Rehabilitation
The study's objective is to evaluate the efficacy of implemented Virtual Reality therapy for patients who have undergone lower limb arthroplasty and are in inpatient rehabilitation.
- Conditions
- Arthropathy, Anxiety, Stress
- Trial name
- NCT06002139
- Testing
- Immersive Virtual Reality Therapy, Conventional rehabilitation
- Where
- Poland
- Volunteers
- 68 people
- Sponsor
- Joanna Szczepańska-Gieracha
Anxiety, Depression
Compassion Training and Mindfulness Training for Social Well-Being and Mental Health
Study Design, Aims, and Population: The present study is a three-arm randomized controlled trial (RCT). The primary aim is to test the relative efficacy of two 8-week online interventions - Compassion Cultivation Training (CCT)…
- Conditions
- Anxiety, Depression, Stress, Burnout
- Trial name
- NCT05227794
- Testing
- Compassion Cultivation Training (CCT), Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Yale University
Childhood Depression, Childhood Anxiety
Integrative Coping Group for Children
The purpose of this study is to examine whether an integrative group-based intervention will help children experiencing psychological and physical distress.
- Conditions
- Childhood Depression, Childhood Anxiety, Pediatric Pain, Migraines
- Trial name
- ToPSY (NCT01813669)
- Testing
- Integrative Coping Group
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
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