Clinical trials: Anxiety Disorders
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety, Depression
Connection to Care: Pilot Study of a Mobile Health Tool for Patients With Depression and Anxiety
This is a pilot feasibility study of a mobile health tool (smartphone app) for primary care patients receiving treatment for depression or anxiety delivered in an integrated primary care-based behavioral health program.
- Trial name
- NCT02497755
- Testing
- App for smartphone, smartphone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Washington
Anxiety Disorders, Complex Regional Pain Syndrome Type II
Regional Anesthesia Military Battlefield Pain Outcomes Study
The purpose of this study is to examine the short and long-term benefits of implementing early regional anesthesia techniques for pain control after a major traumatic injury to one or more extremities during combat in the…
- Conditions
- Anxiety Disorders, Complex Regional Pain Syndrome Type II, Depressive Disorders, Post-Traumatic Stress Disorder
- Trial name
- RAMBPOS (NCT00431847)
- Testing
- Regional Anesthesia, Standard Pain Management Protocol
- Where
- 3 sites in United States
- Volunteers
- 386 people
- Sponsor
- VA Office of Research and Development
Social Anxiety Disorder
Ketamine Infusion for Social Anxiety Disorder
Social Anxiety Disorder (SAD) is common and causes significant impairment. First-line treatments for Social Anxiety Disorder are only partially effective.
- Trial name
- NCT02083926
- Testing
- Ketamine, Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Generalized Anxiety Disorder
Cognitive-Behavioral Therapy and Escitalopram for Generalized Anxiety Disorder(GAD)
The goals of this pilot study are as follows: 1) To disseminate and examine the effectiveness of a manualized, individual, cognitive-behavioral psychotherapy (CBT) for adults with Generalized Anxiety Disorder(GAD), 2) to test the…
- Trial name
- NCT00219349
- Testing
- Cognitive Behavioral Therapy, escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Depression, Anxiety
IntelliCare Study: Artificial Intelligence in a Mobile (AIM) Intervention for Depression
This study will evaluate and compare a smartphone intervention for depression and anxiety that uses machine learning to tailor treatment for participants with the same intervention without the machine learning component.
- Trial name
- AIM (NCT02801877)
- Testing
- IntelliCare, Hub App with the Recommender System, Coaching
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- Northwestern University
Smoking, Pain
Pain and Smoking Study
This purpose of this study is to test the telephone delivery of a cognitive behavioral intervention (CBI), for smoking cessation among Veteran smokers with chronic pain
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS (NCT02971137)
- Testing
- Smoking Cessation plus CBI, Smoking Cessation Standard
- Where
- 2 sites in United States
- Volunteers
- 371 people
- Sponsor
- VA Office of Research and Development
HIV Infections, Behavioral Symptoms
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese…
- Conditions
- HIV Infections, Behavioral Symptoms, Depression, Anxiety
- Trial name
- VITAL (NCT04790201)
- Testing
- Friendship Bench Delivered by Professional Counselor, Friendship Bench Delivered by Lay Counselor, Enhanced Usual Care
- Where
- Vietnam
- Volunteers
- 77 people
- Sponsor
- University of North Carolina, Chapel Hill
Obsessive-Compulsive Disorder
Tolcapone in Obsessive Compulsive Disorder
The proposed study will consist of a 5-week double-blind cross-over study trial of tolcapone in 20 people (ages 18-65). The study will be divided into an initial 2 week phase and a second 2 week phase, with one of the 2 week…
- Trial name
- NCT03348930
- Testing
- Tolcapone 200 MG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Alcohol Dependence, Anxiety Disorder
Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder
The proposed design is a single-group open-label trial. Qualified consenting participants with active alcohol dependence and primary or secondary anxiety disorder will receive monitored disulfiram and lorazepam, in the context of…
- Trial name
- NCT00721526
- Testing
- disulfiram plus lorazepam
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of New Mexico
PTSD, Panic Attacks
Exposure Therapy For Veterans With PTSD And Panic Attacks
To evaluate the feasibility, acceptability and effectiveness of Multiple Channel Exposure Therapy-Veterans (MCET-V) as a treatment for returning service members with comorbid PTSD and panic disorder (PD).
- Trial name
- NCT01033136
- Testing
- Multiple Channel Exposure Therapy - Veterans, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Anxiety Disorders
Transdiagnostic CBT for Comorbid Alcohol Use and Anxiety Disorders
Almost 18 million US adults have alcohol use disorders (AUD), with one third of these individuals also diagnosed with anxiety disorders (AXD).
- Trial name
- NCT03230006
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Take Control
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston University Charles River Campus
Depressive Symptoms, Anxiety Generalized
Digital Data in Mental Health Therapy
The Use of Patient Electronic Communication in Psychiatric Evaluation and Treatment intends to better understand how digital data, social media, and electronic communication can be used in mental health therapy.
- Trial name
- NCT04011540
- Testing
- Digital data
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Anxiety Disorders, Social Phobia
Child and Adolescent Anxiety Disorders (CAMS)
This randomized, controlled trial compared the efficacy of the medication sertraline (Zoloft®), cognitive-behavioral therapy, the combination of these treatments, and placebo for youth with anxiety disorders.
- Conditions
- Anxiety Disorders, Social Phobia, Generalized Anxiety Disorder
- Trial name
- NCT00052078
- Testing
- Sertraline (SRT), Cognitive Behavioral Therapy (CBT)
- Where
- 6 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obsessive-Compulsive Disorder
Digital Health Interventions for Obsessive Compulsive Disorder (OCD)
The investigators are testing two digital health interventions for obsessive compulsive disorder (OCD). The investigators hope that these digital health programs will increase access to treatment for OCD.
- Trial name
- NCT04136626
- Testing
- Perspectives OCD, The Health and Well-Being Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Social Anxiety
Augmenting Exposure Therapy for Social Anxiety With Transcranial Direct Current Stimulation
This study will examine whether transcranial direct current stimulation (tDCS) can be used to improve outcomes from exposure therapy for social anxiety disorder, and facilitate extinction of fear responding toward individuals…
- Trial name
- NCT03743571
- Testing
- transcranial direct current stimulation, exposure therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Nevada, Reno
Anxiety Disorders, Depression
LGBTQ-affirmative CBT for Youth
This study will adapt LGBTQ-affirmative cognitive behavior therapy (CBT) - previously only used with adults - for youth aged 12-17 years.
- Conditions
- Anxiety Disorders, Depression, LGBTQ
- Trial name
- NCT05408858
- Testing
- LGBTQ-affirmative cognitive behavioral group therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Anxiety Depression
Guided Group Telehealth to Deliver Evidence-based Therapeutic Care to Black College Students
The goal of this study is to address the mental health crisis among college students by creating a promising solution for group teletherapy, which is equivalent to individual teletherapy in terms of treatment outcomes.The main…
- Trial name
- NCT07237217
- Testing
- Cognitive Behavioral Therapy (CBT) Coping Skills Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Veronica Tetterton
Fragile x Syndrome
Ganaxolone Treatment in Children With Fragile X Syndrome
This Phase 2 proof-of-concept study is a double-blind, randomized, placebo-controlled, crossover study to investigate ganaxolone treatment in children with fragile x syndrome (FXS).
- Trial name
- NCT01725152
- Testing
- Ganaxolone
- Where
- 2 sites in United States, Belgium
- Volunteers
- 59 people
- Sponsor
- Marinus Pharmaceuticals
Cigarette Smoking, Nicotine Dependence
Treatment of Smoking Among Individuals With PTSD
This study will examine the effect of combining prolonged exposure, a cognitive-behavioral treatment program for post-traumatic stress disorder (PTSD) with medication (varenicline) and counseling treatments for smoking cessation.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
- Trial name
- NCT00937235
- Testing
- Varenicline, Medication Management Counseling, Prolonged Exposure
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania