Clinical trials: Anxiety Disorders
Social Anxiety Disorder (SAD)
A Randomized, Controlled Study of Two At-Home Self-Guided Virtual Reality Interventions for Adults With Social Anxiety Disorder.
This study is to compare two Virtual Reality (VR)-based interventions, BVR-100 and BES-100, for the treatment of Social Anxiety Disorder (SAD).
- Trial name
- BVR-100-102 (NCT06037668)
- Testing
- BVR-100, BES-100
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Sumitomo Pharma America, Inc.
Obsessive-compulsive Disorder
Stepped Care for Treating Obsessive-Compulsive Disorder
This study will determine the effectiveness and cost-effectiveness of a stepped-care treatment program for people with obsessive-compulsive disorder.
- Trial name
- NCT00316355
- Testing
- Traditional CBT, Stepped-Care CBT
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hartford Hospital
Emotional Distress, Burnout, Professional
A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers
This is a pilot randomized waitlist control trial assessing if the feasibility of using a mobile mindfulness app to treat emotional distress and burnout amongst nurses taking care of COVID-19 patients.
- Conditions
- Emotional Distress, Burnout, Professional, Stress, Job, Anxiety
- Trial name
- LIFT-HCW (NCT04816708)
- Testing
- LIFT Mindfulness
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Duke University
Anxiety, Pain
Presence of a Companion During Performance of Neuraxial Labor Analgesia
The purpose of the study is to evaluate if maternal anxiety is improved when a parturient gets her choice with regard to the presence of a companion during epidural catheter placement for labor analgesia.
- Conditions
- Anxiety, Pain, Health Knowledge, Attitudes, Practice
- Trial name
- Companion (NCT02982213)
- Testing
- Companion Present
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Northwestern University
Generalized Anxiety Disorder
Duloxetine for the Treatment of Generalized Anxiety Disorder
This is a 15 week study comparing how well duloxetine and placebo treatments improve generalized anxiety disorder
- Trial name
- NCT00803361
- Testing
- Duloxetine
- Where
- 7 sites in China
- Volunteers
- 210 people
- Sponsor
- Eli Lilly and Company
Social Anxiety Disorder
PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge - 2
This Phase 3 clinical trial is designed to evaluate the efficacy, safety, and tolerability of the acute administration of 3.2 µg of PH94B to relieve symptoms of anxiety in adult subjects with social anxiety disorder (SAD) during…
- Trial name
- Palisade-2 (NCT05011396)
- Testing
- PH94B Nasal Spray
- Where
- 15 sites in United States
- Volunteers
- 228 people
- Sponsor
- VistaGen Therapeutics, Inc.
MDD
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment
To investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in active adults with MDD, 18 to 35 years old, who are experiencing an inadequate selective serotonin reuptake inhibitor (SSRI)/serotonin…
- Trial name
- NCT02013609
- Testing
- Brexpiprazole
- Where
- 24 sites in United States
- Volunteers
- 48 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hoarding Disorder
Cognitive Rehab and Exposure Treatment for Hoarding
This project will utilize a novel behavioral intervention for hoarding disorder that takes into account age and neurocognitive factors.
- Trial name
- CREST (NCT02402647)
- Testing
- Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST), Exposure Therapy (ET)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Fear Conditioning
Influence of Escitalopram on Fear Conditioning
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking an antidepressant medication. This medication is called Lexapro (Escitalopram).
- Trial name
- NCT01398514
- Testing
- Escitalopram
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sars-CoV2, Serum; Disease
Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonié in the Context of the COVID-19 Pandemic
The question of the immune response of the population, particularly of professional populations in contact with vulnerable populations (such as those with chronic conditions such as cancer), is an important issue.
- Trial name
- PRO-SERO-COV (NCT04426006)
- Testing
- PRO-SERO-COV
- Where
- France
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut Bergonié
Self-Injurious Behavior, Deliberate Self-Harm
A Study Examining Adolescents With Non-Suicidal Self-Injury
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI).
- Trial name
- RDoC (NCT02947308)
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Chronic Low Back Pain, Negative Affectivity
Treating Negative Affect in Low Back Pain Patients
This study will examine how the use of antidepressant, physical therapy, and combination of both affects pain, function, and depression outcomes in chronic low back pain patients.
- Trial name
- TNA-LBP (NCT04747314)
- Testing
- Antidepressant, Enhanced Fear Avoidance Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 308 people
- Sponsor
- Ajay Wasan, MD, Msc
Child Anxiety, Anxiety Disorders
Kids FACE FEARS Comparative Effectiveness Research
The Kids FACE FEARS (Kids Formats of Anxiety Care Effectiveness study For Extending the Acceptability and Reach of Services) is a large-scale, streamlined, pragmatic Randomized Controlled Trial (RCT) evaluating Therapist-Led CBT…
- Conditions
- Child Anxiety, Anxiety Disorders, Anxiety, Anxiety Symptoms
- Trial name
- NCT03707158
- Testing
- Therapist-Led CBT (telehealth, office-based, or hybrid), Guided Online CBT
- Where
- 8 sites in United States
- Volunteers
- 305 people
- Sponsor
- Boston Medical Center
Depression, Anxiety
Community Intervention to Improve Depressive Symptoms Among Older Adults (VIDACTIVA)
The goal of this pilot trial is to test how feasible is to conduct a large clinical trial that evaluate both implementation and effectiveness outcomes of a community-based interventions for older adults with depression in…
- Trial name
- VIDACTIVA1 (NCT06065020)
- Testing
- VIDACTIVA sessions, Standard Care
- Where
- Peru
- Volunteers
- 72 people
- Sponsor
- Universidad de San Martín de Porres
Acute Coronary Syndrome, Coronary Artery Disease
Remote-delivered MBCT for SCAD Survivors
Spontaneous coronary artery dissection (SCAD) is an important cause of cardiac events, primarily affecting young healthy women with no cardiovascular risk factors.
- Conditions
- Acute Coronary Syndrome, Coronary Artery Disease, Anxiety, Sleep
- Trial name
- NCT04983680
- Testing
- MBCT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Arachnophobia, Cynophobia
Telemedicine-Based Virtual Reality Clinic for the Treatment of Phobias
The purpose of this study is to assess the feasibility of conducting a randomized controlled efficacy trial comparing the delivery of exposure therapy via a telemedicine-based virtual reality clinic (Doxy.me VR) vs.
- Conditions
- Arachnophobia, Cynophobia, Ophidiophobia
- Trial name
- NCT06302868
- Testing
- Telemedicine Exposure Therapy Using Photos and Videos, Telemedicine-Based Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of South Florida
Panic Disorder
Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder
This is a 5-year double blind, randomized, controlled, trial conducted at three treatment sites, aimed at showing the acute and longer-term effects of DCS augmentation of exposure-based CBT for panic disorder relative to placebo…
- Trial name
- DCSPanic (NCT00790868)
- Testing
- d-cycloserine
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- Boston University Charles River Campus
Opioid-use Disorder, Stress Related Disorder
Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment (R33 Phase)
This will be a randomized controlled trial (RCT) designed to compare live-online Mindful Recovery Opioid Care Continuum (M-ROCC) groups with a live-online control group on the primary outcome of number of biochemically confirmed…
- Conditions
- Opioid-use Disorder, Stress Related Disorder, Anxiety, Pain Interference
- Trial name
- Mindful-OBOT (NCT04278586)
- Testing
- Live-Online M-ROCC, Live-Online Control
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Cambridge Health Alliance
Anxiety Disorders
Transdiagnostic Cognitive Behavioral Treatment for Anxiety
This study is a randomized controlled trial examining the effectiveness of a transdiagnostic cognitive behavioral treatment (CBT) in improving Veterans' community reintegration and quality of life.
- Trial name
- NCT03810456
- Testing
- Intensive Cognitive Behavior Therapy (iCBT), Standard Cognitive Behavior Therapy (sCBT)
- Where
- United States
- Volunteers
- 359 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorder of Adolescence
Sequencing CBT for Child Anxiety: CBT Plus Sertraline Versus Switch to Sertraline
The purpose of this study is to determine whether cognitive behavioral therapy (CBT) in combination with sertraline (SRT) is more effective than SRT alone in treating children and adolescents with anxiety disorders (after an…
- Trial name
- NCT01977729
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University