Clinical trials: Anxiety Symptoms, open to volunteers
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Depressive Symptoms, Perinatal Loss
e-Perinatal Butterfly: An Embedded Study for Parents Experiencing Perinatal Loss
This study is part of the e-Perinatal project and is embedded within the parent e-Perinatal cluster randomized controlled trial (NCT07613008). No additional randomization is performed for this embedded study.
- Conditions
- Depressive Symptoms, Perinatal Loss, Perinatal Grief, Anxiety Symptoms
- Trial name
- e-Butterfly (NCT07898176)
- Testing
- e-Perinatal Butterfly, Standard routine maternal care
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Seville
Anxiety Symptoms, Anxiety Disorders
TOUCHminds: Help-seeking in Adolescents With Anxiety
Adolescents frequently experience clinical and subclinical anxiety symptoms, yet many avoid seeking professional help. While universal interventions exist to promote help-seeking, targeted programs for adolescents with elevated…
- Trial name
- TOUCHminds (NCT07366580)
- Testing
- TOUCHminds - Web-Based Intervention
- Where
- Portugal
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depression and Anxiety Symptoms, Multiple Sclerosis
An Online Tailored Cognitive Therapy-Based Intervention for Depression in Multiple Sclerosis: ACTION-MS Online
Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease.
- Trial name
- ACTION-MS onli (NCT07875309)
- Testing
- ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression., The 'Health and Wellbeing in MS' website
- Where
- 2 sites in Australia, Canada
- Volunteers
- 240 people
- Sponsor
- University of Melbourne
Post-traumatic Stress Symptoms, Anxiety
Psychological Prehabilitation for Complex Gastrointestinal Surgery
The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI.
- Conditions
- Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
- Trial name
- PREPARE-GI (NCT07865052)
- Testing
- PREPARE-GI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Mental Health, Parenting / Maternal Behavior
Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation
This study examines online programs for parents navigating divorce or separation. Researchers will study whether a self-guided mindfulness app called Healing Hearts, followed by a self-guided online parenting program called the…
- Conditions
- Mental Health, Parenting / Maternal Behavior, Parenting Anxiety, Parenting Behavior
- Trial name
- NCT07871916
- Testing
- Healing Hearts, electronic New Beginnings Program, Curated internet resources
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Functional Neurological Disorders, Multiple Sclerosis
Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS.
- Trial name
- FTNF-SEP (NCT07849816)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Depression - Major Depressive Disorder, Generalized Anxiety Disorder
Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders
The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms…
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder, Generalized Anxiety, Anxiety
- Trial name
- UltraPsyBrief (NCT06909669)
- Testing
- Group ultra-brief transdiagnostic cognitive-behavioral therapy, Group brief transdiagnostic cognitive-behavioral therapy, Individual ultra-brief transdiagnostic cognitive-behavioral therapy
- Where
- 2 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Universidad de Córdoba
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
HBOT Effects on First Responders' Cognition and Well-Being
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury.
- Conditions
- Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT07852728
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Stress, Anxiety
Effects of Probiotic Supplementation on Stress and Anxiety in Students
This randomized, double-blind, placebo-controlled study evaluates the efficacy and safety of an 8-week probiotic supplementation (Lactobacillus plantarum LP140 and Bifidobacterium breve BB010 in total daily dose 1 × 10¹⁰ CFU or…
- Conditions
- Stress, Anxiety, Sleep, Gastro-intestinal Symptoms in Healthy Subjects
- Trial name
- PROfoS (NCT07470645)
- Testing
- Probiotics
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Depression and Anxiety Symptom, Anger
Implementing BEAM: A Scalable Digital Mental Health Program, for Families of Children Referred to Neurodevelopmental Services
Families of children with neurodevelopmental differences (NDDs) experience disproportionately high levels of parenting stress and mental health difficulties, including elevated depression, anxiety, and caregiver burden.
- Conditions
- Depression and Anxiety Symptom, Anger, Parenting, Stress (Psychology)
- Trial name
- NCT07837791
- Testing
- The Building Emotional Awareness and Mental Health (BEAM) Program
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Anxiety Symptoms, Screen Time
Effects of Digital Detox on Mental Health in Young Adults
The goal of this clinical trial is to learn whether a short, self-guided program for cutting down smartphone screen time can reduce symptoms of depression in young adults.
- Conditions
- Anxiety Symptoms, Screen Time, Depressive Symptoms
- Trial name
- NCT07827703
- Testing
- App-based smartphone screen time restriction program
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Bergen
Substance Use Disorders, Posttraumatic Stress Symptom
Safe & Sound Protocol in Adults With Trauma and SUD
This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma.
- Conditions
- Substance Use Disorders, Posttraumatic Stress Symptom, Anxiety
- Trial name
- NCT07219056
- Testing
- Safe and Sound Protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Caron Treatment Centers
Anxiety, Anxiety Disorders and Symptoms
Video Game Play to Alleviate Adolescent Anxiety
Adolescence is a critical period for the onset and maintenance of anxiety disorders, which raises the importance of intervening early; one possibility of doing so is via digital interventions.
- Trial name
- NCT05923944
- Testing
- Eco-Rescue, Bejelewed 3
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Pancreatic Neoplasms, Pancreatic Cancer
Five-Element Music Therapy for Psychological Distress in Pancreatic Cancer Chemotherapy
Ziwu Liuzhu Five-Element Music Therapy is a non-pharmacological intervention grounded in the traditional Chinese medicine theory of "five tones corresponding to the five viscera and five emotions," integrated with the…
- Conditions
- Pancreatic Neoplasms, Pancreatic Cancer, Anxiety, Depression and/or Anxiety Symptoms
- Trial name
- FEMT-PC (NCT07796906)
- Testing
- Ziwu Liuzhu Five-Element Music Therapy, Mindfulness-Based Stress Reduction
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
PTSD Symptoms, Anxiety Symptoms
Clinician Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center Responders in Florida
This study examines mental health challenges among World Trade Center (WTC) General Responders, who continue to experience significant psychological trauma from the WTC collapse.
- Conditions
- PTSD Symptoms, Anxiety Symptoms, Depression Symptoms, Sleep Disturbance
- Trial name
- PTSDCoach911 (NCT06648928)
- Testing
- Clinician Supported PTSD Coach, Self Managed PTSD Coach
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Florida International University