Clinical trials: Aortic Arch
Aortic Arch; Aneurysm, Dissecting
Study of the Thoraflex™ Hybrid Device for the Treatment of Aneurysm/Dissection of the Descending Thoracic Aorta
The purpose of this national observational study is to evaluate the Thoraflex™ Hybrid vascular prosthesis in the replacement of the aortic arch and the treatment of aneurysm/dissection of the descending thoracic aorta in relation…
- Trial name
- NCT03735472
- Testing
- Thoraflex™ Hybrid
- Where
- 37 sites in France
- Volunteers
- 351 people
- Sponsor
- Vascutek Ltd.
Aorta Dissection, Aorta Aneurysm
Total Endovascular Aortic Arch Re-construction Study(TEARS)
The purpose of this study is to investigate the short to mid term efficacy and safety of a newly-developed branched stent graft in patients who had complex aortic lesions, such as ascending aortic/arch aneurysm, pseudo-aneurysm…
- Trial name
- NCT01496833
- Testing
- Ankura Branched/Fenestrated Stent Graft
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xijing Hospital
Aortic Aneurysm, Thoracic, Aorta, Lesion
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
The objective of this study is to determine whether the GORE® TAG® Thoracic Branch Endoprosthesis is safe and effective in treating lesions of the aortic arch and descending thoracic aorta.
- Trial name
- SSB 11-02 (NCT02777528)
- Testing
- GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure
- Where
- 39 sites in United States, Japan
- Volunteers
- 79 people
- Sponsor
- W.L.Gore & Associates
Behcet's Disease, Churg-Strauss Syndrome
VCRC Patient Contact Registry Patient-Reported Data Validation Study
The purpose of this study is to provide validation of patient-reported data in the VCRC Patient Contact Registry by comparing patient-reported data with data provided by the physician who is the primary provider caring for the…
- Conditions
- Behcet's Disease, Churg-Strauss Syndrome, Giant Cell Arteritis, Wegener Granulomatosis
- Trial name
- NCT02190942
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- University of South Florida
Takayasu Arteritis
Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis
Assessing disease activity in people with Takayasu's arteritis is difficult, as most people with the disease do not exhibit visible, measurable symptoms.
- Trial name
- NCT00744952
- Where
- 5 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- Peter Merkel
Thoracic Aortic Aneurysms, Dissecting, Aneurysm
Endovascular Treatment of Thoracic Aortic Disease
The purpose of this study is to assess the role endovascular therapy to treat aortic disease involving the ascending aorta, the aortic arch, and the visceral segment of the aorta (or thoracoabdominal aorta)
- Conditions
- Thoracic Aortic Aneurysms, Dissecting, Aneurysm, Ascending Aorta Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- EVOLVE Aorta (NCT00583817)
- Testing
- Endovascular stent-graft implantation
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Matthew Eagleton
Takayasu Arteritis
Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis
The purpose of this study is to demonstrate that [18F]FDG PET is a a better method than clinical and laboratory values for the identification and assessment of inflammatory activity in patients with Takayasu Arteritis (TA)…
- Trial name
- NCT01532167
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Aortic Aneurysm, Aortic Aneurysm and Dissection
A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta
The Goal of this Clinical Study is to evaluate the safety and effectiveness of the Rapidlink device in the repair or replacement of the supra-aortic vessels during open surgical repair of aortic disease affecting the thoracic…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm and Dissection, Aortic Diseases, Aneurysm of Aorta, Thoracic
- Trial name
- RAPID (NCT07078383)
- Testing
- Rapidlink
- Where
- 21 sites in United States, Austria and 3 more
- Volunteers
- 150 people
- Sponsor
- Vascutek Ltd.
Acute Type A Aortic Dissection, Hypothermia
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China.
- Conditions
- Acute Type A Aortic Dissection, Hypothermia, Total Aortic Arch Replacement, Frozen Elephant Trunk
- Trial name
- AHEAD (NCT07150559)
- Testing
- Arch-Clamping Technique under Mild Hypothermia, Arch-Clamping Technique under Moderate Hypothermia, Total Arch Replacement combined Frozen Elephant Trunk Implantation using Bilateral Antegrade Cerebral Perfusion under Moderate Hypothermic Circulatory Arrest
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Dissection
the Aorta Arch Stent Graft System Combined With the Endovascular Needle System in Situ Fenestration
A prospective, multi-center, single-group target value method to evaluate the safety and effectiveness of the Aorta Arch Stent Graft System combined with the Endovascular Needle System in situ fenestration technology in the…
- Trial name
- NCT05126446
- Testing
- the Aorta Arch Stent Graft System combined with the Endovascular Needle System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Aortic Aneurysm, Thoracic
NICardipine Neuroprotection in AortiC Surgery (NICNACS)
Objective The objective of this study is to discover whether an infusion of nicardipine is able to reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass (CPB) for aortic surgery.
- Trial name
- NICNACS (NCT00508118)
- Testing
- Nicardipine, 0.9% saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Penetrating Ulcer of Aorta, Aneurysm Aortic
Evaluation of the Valiant Captivia Physician Fenestrated Stent Graft System in Aortic Arch and Descending Thoracic Aorta Pathologies
The study objectives are to assess safety and effectiveness, measured acutely and at the 30-day visit after implantation of the Valiant Captivia physician fenestrated Stent Graft.
- Conditions
- Penetrating Ulcer of Aorta, Aneurysm Aortic, Type B Aortic Dissection, Residual Dissection After Type A Repair
- Trial name
- EVERGREEN (NCT05479305)
- Testing
- The Valiant Captivia Stent Graft
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Ceric Sàrl
Coarctation of Aorta
Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
- Trial name
- NCT02835703
- Testing
- Surgical repair of coarctation of aorta
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Pericarditis, Tako-TSUBO Cardiomyopathy
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
INFLAME-BANK is a French multicenter prospective observational ancillary study of the international EACVI-INFLAME project. It aims to establish a biobank and perform immunophenotyping and proteomic analyses in patients with…
- Conditions
- Pericarditis, Tako-TSUBO Cardiomyopathy, Myocarditis, Inflammatory Cardiomyopathies
- Trial name
- INFLAME-BANK (NCT07737470)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Arch Replacement, Hemi Arch Replacement
Neurologic Injury Following Aortic Arch Replacement
Investigators are seeking to learn how well different cooling temperatures along with different blood flow pathways to the brain reduce the risk of injury to the brain in participants planning to undergo elective aortic arch and…
- Trial name
- NCT02750423
- Testing
- DHCA+RCP, MHCA + SACP
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Giant Cell Arteritis, Takayasu Arteritis
Biologics in Refractory Vasculitis: A Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis
Vasculitis occur when the body's immune system, rather than protecting the body, attacks blood vessels, causing injury to the vessel and the part of the body it supplies with blood.
- Conditions
- Giant Cell Arteritis, Takayasu Arteritis, Cogan Syndrome, Relapsing Polychondritis
- Trial name
- BIOVAS (NCT05168475)
- Testing
- Rituximab, Infliximab, Tocilizumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis
One-Time DNA Study for Vasculitis
The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels.
- Conditions
- Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis, Granulomatosis With Polyangiitis (Wegener's), Microscopic Polyangiitis
- Trial name
- NCT01241305
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
AAT9
Further Evaluation of Safety and Performance of the NEXUS Aortic Arch Stent Graft System and the Custom-Made NEXUS Multibranch™ Aortic Arch Stent Graft System
The goal of this observational study is to collect clinical information on how safe, and how well the NEXUS Aortic Arch Stent Graft System and the Custom-Made NEXUS DUO™ Aortic Arch Stent Graft System work for the treatment of…
- Trial name
- ARCUS (NCT05636527)
- Where
- 18 sites in Belgium, Cyprus and 8 more
- Volunteers
- 70 people
- Sponsor
- Endospan Ltd.
Congenital Disorders
Aortic Arch Reconstruction
Abnormalities of the aorta have been identified in patients who have undergone repair of coarctation of the aorta by various surgical techniques.
- Trial name
- NCT00277940
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Healthcare of Atlanta