Clinical trials: Aortic Dissection Aneurysm
Thoracic Aortic Aneurysm (TAA), Aortic Dissection
POCUS Screening for TAA in Hypertensive Patients in the ED
The investigators are going to recruit hypertensive patients in the emergency department of Prince of Wales Hospital. Point-of-care ultrasound of the aorta and measurements of the aortic diameter will be obtained.
- Trial name
- NCT06854588
- Testing
- Point-of-care ultrasound
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Aortic Aneurysm, Aortic Dissection
Cardiovascular Health Improvement Project
The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Bicuspid Aortic Valve (BAV), Heart Failure
- Trial name
- CHIP (NCT02306200)
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aortic Aneurysm, Aortic Aneurysm Abdominal
AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation
This study will test how well an artificial intelligence (AI) software called Aorta AIM measures the size of the aorta (the body's main blood vessel) from CT scans.
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Aortic Aneurysm and Dissection, Aortic Aneurysm, Thoracoabdominal
- Trial name
- AI-CARE (NCT07438327)
- Testing
- Aorta AIM Automated Measurement, Expert Radiologist Manual Measurement
- Where
- 3 sites in United States, Brazil
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aiatella Oy
Aortic Aneurysm, Aortic Aneurysm and Dissection
Multidisciplinary Analysis by Morphological and Mechanical Evaluation of the Aortic Wall in Patients Undergoing Cardiac Surgery.
Surgical indication in patients suffering from Ascending aorta aneurysm is currently based mainly on the maximum diameter of the aortic dilatation and on the yearly growth rate.
- Trial name
- NCT07422129
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Aortic Aneurysm, Aortic Dissection
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MAC:H-TAD (NCT04005976)
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Aortic Root Aneurysm, Aortic Root Dissection
Aortic Valve Sparing Root Replacement Versus Bentall
This study was designed to evaluate the hypothesis that the operative and midterm results of valve-sparing aortic root replacement are equivalent to those of the Bentall.
- Trial name
- NCT03604913
- Testing
- Aortic valve sparing operation, Bentall operation
- Where
- Egypt
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aortic Aneurysm and Dissection
MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta
The main objective is to compare the mitochondrial dynamic between patients operated for aneurysm of ascending aorta or type A aortic dissection (AAD) or control group
- Trial name
- MITAORTA (NCT05434481)
- Testing
- Mitochondrial dynamic analysis in the aorta samples and metabolomic profiling in the aortic diseases
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high…
- Conditions
- Bicuspid Aortic Valve, Thoracic Aortic Aneurysm, Aortic Dissection
- Trial name
- AoRTAS (NCT04083118)
- Testing
- clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aortic Aneurysm
Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta
An in-house calculator was developed to calculate the appropriate contrast dose, rather than standardly administering a 120ml dose.
- Trial name
- NCT05716568
- Testing
- Contrast dose reduction, CT-angiography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Screening, Aortic Aneurysm and Dissection
A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases
The primary hypothesis is that a tailored programme of genetic and imaging screening of first- and second-degree relatives of patients affected by non-syndromic forms of thoracic aortic diseases will identify individuals at risk…
- Conditions
- Screening, Aortic Aneurysm and Dissection, Genetic Disease
- Trial name
- ReST (NCT03861741)
- Testing
- WES, MRI, TTE
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Aortic Dissection, Family Research
Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups.
- Conditions
- Aortic Dissection, Family Research, Aortic Dissection, Familial, With or Without Aortic Aneurysm
- Trial name
- NCT04439565
- Testing
- movement
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese Medical Association
Marfan Syndrome, Loeys-Dietz Syndrome
Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes
The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes.
- Conditions
- Marfan Syndrome, Loeys-Dietz Syndrome, Thoracic Aortic Aneurysm and Dissection Syndromes, Ehlers-Danlos Type IV Syndrome
- Trial name
- NCT02213484
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aortic Aneurysm, Thoracic, Aneurysm, Dissecting
A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection
This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection
- Trial name
- ARSGBTAAD (NCT03010514)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Aneurysm Dissecting
Gender-related Differences in Chinese Patients With AAD
Few data exist on gender-related differences in clinical features, management, and outcomes of acute aortic dissection (AAD) in China.
- Trial name
- NCT02200835
- Volunteers
- 2,015 people, healthy volunteers welcome
- Sponsor
- General Hospital of Beijing PLA Military Region
Connective Tissue Disease, Dissecting Aneurysm
Study of Heritable Connective Tissue Disorders
The purposes of this study are to identify the genes responsible for inherited connective tissue disorders and learn about the range of medical problems they cause.
- Conditions
- Connective Tissue Disease, Dissecting Aneurysm, Ehlers Danlos Syndrome, Marfan Syndrome
- Trial name
- NCT00001641
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)