Clinical trials: Aortic Stiffness
Rheumatoid Arthritis, Stiffness, Aortic
Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis
The investigators will study the effects of methotrexate on blood pressure, arterial stiffness and endothelial function in patients with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Stiffness, Aortic, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03254589
- Testing
- Methotrexate, Sulfasalazine, Other DMARDs
- Where
- Australia
- Volunteers
- 124 people
- Sponsor
- Flinders University
Hypertension, Cardiovascular Diseases
The Effects of Strawberries on Blood Pressure in Postmenopausal Women
Cardiovascular disease (CVD) is the leading cause of death in the US. Statistics show that approximately 91% of individuals with CVD have vascular dysfunction.
- Conditions
- Hypertension, Cardiovascular Diseases, Vascular Diseases
- Trial name
- NCT02099578
- Testing
- 25 g of Freeze-dried Strawberry Powder, 50 g of Freeze-dried Strawberry Powder
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Type 1 Diabetes
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes.
- Trial name
- WBH002 (NCT05653518)
- Testing
- Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Arterial Calcification, Aortic Stiffness
Short and Long-term Results of Arterial Stiffness and Central Aortic Pressure After Kidney Transplantation
Central blood pressure and pulse wave velocity were measured using a Complior Analyse device in Short and Long-term after kidney transplantation.
- Conditions
- Arterial Calcification, Aortic Stiffness, High Blood Pressure (& [Essential Hypertension])
- Trial name
- PWV/CP/KTx (NCT02443454)
- Testing
- Device: Complior Analyse System, Tanita BC 418- Bioelectrical impedance analysis
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Prehypertension, Gout
Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure
High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures.
- Conditions
- Prehypertension, Gout, Pulse Wave Velocity, Hypertension
- Trial name
- NCT01472692
- Testing
- Febuxostat
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aortic Stiffness, Hypertension
Validation of the Schiller BR-102 Plus PWA Device to Measure Central and Peripheral Hemodynamics
The significance of parameters of the central hemodynamic is based upon their strong association with left ventricular hypertrophy and target organ damage at the heart.
- Trial name
- BR-102 (NCT02596165)
- Testing
- Pulse wave analysis measurement with Schiller BR-102 Plus PWA device
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Basel
Hypertension, Aortic Aneurysm
Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
Aortic stiffness is an important imaging biomarker of vascular aging. The ascending aorta is the most elastic segment, and it is excluded by reference non-invasive method carotid to femoral pulse wave velocity (PWV).
- Conditions
- Hypertension, Aortic Aneurysm, Bicuspid Aortic Valve, Marfan Syndrome
- Trial name
- InSide-CC (NCT05711693)
- Testing
- Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
End Stage Renal Disease, Arterial Stiffness
The Effect of Nocturnal Haemodialysis on Arterial Stiffness
Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance.
- Trial name
- NCT00641875
- Testing
- Nocturnal Hemodialysis
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Aortic Coarctation, Arterial Stiffness
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV)…
- Conditions
- Aortic Coarctation, Arterial Stiffness, PULSE WAVE VELOCITY, Functional Magnetic Resonance Imaging
- Trial name
- LOVE-COARCT (NCT03262753)
- Testing
- Surgery, Balloon dilation, Stent
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Aortic Aneurysm, Abdominal
Impact of Grafts and Endografts for Abdominal Aneurysms on Arterial Stiffness.
The purpose of this study is to evaluate by non-invasive methods the change in central hemodynamics and arterial stiffness produced by grafts and endografts after abdominal aortic aneurysm repair.
- Trial name
- NCT02642952
- Testing
- non-invasive methods
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
First, investigators must determine the physiological standards across age classes of myocardial stiffness estimated by Elastography in ultrafast (estimated right ventricular stiffness [VD] and left ventricular [LV]).
- Trial name
- NCT02619825
- Testing
- Echography, Elastography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Obesity Adult Onset
Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses to Exercise in Obese Males
It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals.
- Trial name
- NCT04465110
- Testing
- Grape Seed Extract
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Bicuspid Aortic Valve
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging
The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients…
- Trial name
- IRM-BAO (NCT03474159)
- Testing
- Magnetic Resonance Imaging, Transthoracic echocardiography, Echography UltraFast
- Where
- France
- Volunteers
- 100 people
- Sponsor
- French Cardiology Society
Coronary Arterial Disease (CAD), Arterial Stiffness
SCAPIS 2 Cardio - Vibrometer Based Pulse Wave Analysis and CVD Risk Assessment
This clinical investigation will evaluate a novel contactless technology for assessing arterial stiffness and pulse wave characteristics and explore its potential in assessment of coronary artery disease, aortic stenosis and…
- Conditions
- Coronary Arterial Disease (CAD), Arterial Stiffness, Aortic Valve Disease, Heart Failure
- Trial name
- NCT07001007
- Testing
- Coronary Computer Tomography (CCTA), Laser Doppler Vibrometry and single-lead ECG, Echocardiography
- Where
- Sweden
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Arteriopathic Disease, Arterial Calcification
The Effects of Hemodialysis Session on Vascular Stiffness
Central blood pressure and pulse wave velocity were measured using a Complior Analyse device before and immediately after the end of the dialysis session.
- Conditions
- Arteriopathic Disease, Arterial Calcification, Complication of Hemodialysis, Aortic Stiffness
- Trial name
- PWV/CP/HD (NCT02443376)
- Testing
- Complior Analyse System, BCM- Body Composition Monitor
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Thoracic Aortic Dissection
Trial of Exercise in Aortic Dissection Survivors
The primary objective of this study is to test the safety and mental health benefits of a guided exercise program for people who survived an acute aortic dissection. This study is designed to answer several questions: 1.
- Trial name
- NCT05610462
- Testing
- Guided Exercise Training Program, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hypertension, Diabetes
Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries
The study is being done to see if a drug shown to lower the risk of heart failure is also effective in reducing the stiffness of the arteries.
- Trial name
- EFFORT (NCT00829296)
- Testing
- nebivolol, Metoprolol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Hypertension
Watermelon Supplementation and Arterial Stiffness
Increased abdominal obesity (waist circumference) and systolic blood pressure (BP) are main risk factors for the metabolic syndrome. Approximately 60% of adults in the United States are prehypertensive or hypertensive.
- Trial name
- NCT01185041
- Testing
- Watermelon Extract
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Florida State University
Cardiovascular Disease, Chronic Kidney Disease
Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease (CVD) in older adults with…
- Trial name
- NCT00874432
- Testing
- angiotensin converting enzyme inhibitor, lisinopril
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aortic Stenosis
Role of Elastin Metabolites in Aortic Remodelling in AS
Around 1-2% of people are born with a 'bicuspid' aortic valve, with only two cusps instead of the common 'tri-leaflet' valve. People with this valve develop dysfunction of the valve (narrowing or leakage) at a much earlier age.
- Trial name
- ELASTIC-AS (NCT03883490)
- Testing
- ECG, Blood test and biobanking, Trans-thoracic Echocardiogram
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Leicester