Clinical trials: Aortic Surgery
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Elective Endovascular Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours, Elective Open Abdominal Aortic Surgery With an Expected Surgical Duration Exceeding 2 Hours
The Hypotension Prediction Index Versus Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery
The standard procedure during general anesthesia is to monitor vital functions, including cardiovascular functions such as cardiac electrical activity, using continuous ECG recording, blood pressure measurement with a…
- Trial name
- HYPE-AORTA (NCT07510451)
- Testing
- HPI guided heamodynamic monitoring, Standard Heamodynamic Managament according to APCO Monitoring
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Aortic Dissection Type A, Acute Kidney Injury Cardiac Surgery
Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery
This single-centre retrospective observational cohort study evaluated the association between preoperative cuff-derived ankle-brachial index (ABI) and postoperative acute kidney injury (AKI) in adults undergoing emergency repair…
- Trial name
- NCT07668830
- Testing
- Preoperative Ankle-Brachial Index
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cardiac and Aortic Surgery
Echography to Predict Radial Artery Catheterization Failure (EPRAC)
In patients undergoing cardiac or aortic surgery, the placement of a radial KTA is sometimes difficult, the purpose of this study is to do an ultrasound in order to evaluate the diagnostic values of the internal diameter of the…
- Trial name
- EPRAC (NCT04730479)
- Where
- France
- Volunteers
- 330 people
- Sponsor
- University Hospital, Montpellier
Endovascular Surgery, Medical Quality
Type B Aortic Dissection Quality Control Platform
This study aims to establish a multicenter, prospective, observational registry database for type B aortic dissection based on approximately 60 regional sentinel hospitals across China.
- Conditions
- Endovascular Surgery, Medical Quality, Prognostic Early Warning, Stanford Type B Aortic Dissection
- Trial name
- NCT07745309
- Testing
- Endo vascular repair
- Volunteers
- 2,375 people
- Sponsor
- Chang Shu
Intensive Care Unit, Coronary Artery Bypass Grafting (CABG)
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy. A total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil/kg body weight…
- Conditions
- Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
- Trial name
- MODIFY CSX (NCT06279793)
- Testing
- Fish Oil, Intravenous 0.9% Sodium Chloride
- Where
- 10 sites in Germany
- Volunteers
- 550 people
- Sponsor
- GCP-Service International West GmbH
Cardiac Surgery, Coronary Artery Bypass Graft
Micro- and Macro-Circulation in Cardiac Surgery Patients
The hypothesis under the study is that there could be a link between a dysfunction in peripheral microcirculation, sublingual microcirculation or cardiovascular control and the development of post cardiac surgery major…
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft, Surgical Aortic Valve Replacement
- Trial name
- MiMaC (NCT05706545)
- Testing
- Acquisition of cardiovascular signals and microcirculation sidestream darkfield images
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Aortic Dissection, Surgery (Cardiac)
Immune-Inflammatory Markers in Aortic Dissection
Identifying early on which patients with acute aortic dissection require closer monitoring may help with care planning. If simple, inexpensive values obtained from routine blood tests can provide additional information for…
- Conditions
- Acute Aortic Dissection, Surgery (Cardiac), Systemic Immune-inflammation Index, Postoperative Death
- Trial name
- NCT07683260
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Bursa City Hospital
Cardiac Surgery, Peri Operative Medicine
Risk Factors of Atrial Fibrillation After Cardiac Surgery
Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death.
- Conditions
- Cardiac Surgery, Peri Operative Medicine, Thoracic Surgery, Cardiopulmonary Bypass
- Trial name
- PFAS (NCT07625033)
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Echocardiography, Aortic Valve
Short- and Medium-term Results of New Generation Aortic
Over the past decade, aortic valve replacement surgery has undergone significant changes in terms of both the approaches and the prostheses used.
- Conditions
- Echocardiography, Aortic Valve, Cardiac Surgery, Mortality
- Trial name
- RVANG (NCT05055089)
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Aortic Aneurysm, Surgery
Evaluation of the Effectiveness of Ischemic Pre-conditioning on the Morbidity and Mortality of Open Surgery of Thoracoabdominal Aortic Aneurysms.
Patients having a planned open surgery of thoracoabdominal aortic aneurysms and enrolled in the study will be randomized the day of the surgery in 2 groups: Arm 1 : Patients with aortic clamping with pre-conditioning Arm 2 …
- Trial name
- EPICATA (NCT03718312)
- Testing
- clamping with pre-conditioning (PCl)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Rouen
Aki After Ascending Aortic Surgeries
Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB).
- Trial name
- NCT06958367
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Coronary Arterial Disease (CAD), Valve Replacement
Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery
Evacuation of pericardial blood by posterior pericardiotomy or use of a posterior pericardial chest tube lowers postoperative atrial fibrillation (POAF) rates after cardiac surgery by 45-68%.
- Conditions
- Coronary Arterial Disease (CAD), Valve Replacement, Aortic Surgery
- Trial name
- PROPER (NCT06800781)
- Testing
- Prolonged treatment with posterior pericardial chest tube plus standard care
- Where
- Sweden
- Volunteers
- 624 people
- Sponsor
- Region Skane
Aortic Surgery, Extracorporeal Circulation
Clindamycin as an Alternative to Vancomycin in Patients Undergoing Aortic Cardiac Surgery With Extracorporeal Circulation (ECC)
Antibiotic prophylaxis is essential for all types of cardiac surgery under Extracorporeal Circulation (ECC), in order to reduce the incidence of surgical site infection (SSI).
- Trial name
- CLINDAPASS (NCT07267013)
- Testing
- Clindamycin
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG)
Metabolic Profile and Tissue Perfusion in Patients Undergoing Open Heart Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the present study is to investigate the protective effect of minimal invasive versus the conventional extracorporeal circulation on tissue homeostasis as evidenced by the preservation of tissue metabolism and cerebral…
- Conditions
- Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG), Cardiac Surgery
- Trial name
- MiECC MET (NCT07516938)
- Testing
- Real-time tissue oximetry monitoring
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Aortic Coarctation, Retrospective Studies
Prevalence and Risk Factors for Hypertension and Recoarctation in Patients Operated for Aortic Coarctation
Multicenter Retrospective Study Over a 14-Year Period From 2010 to 2024
- Conditions
- Aortic Coarctation, Retrospective Studies, Cohort Studies, Hypertension
- Trial name
- PRECOHA (NCT07499609)
- Where
- France
- Volunteers
- 901 people
- Sponsor
- Institut Saint Pierre
Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm
Terumo Aortic Global Endovascular Registry
Multi-arm, multi-center, open label, prospective observational registry designed to obtain safety and performance data on the use of CE marked and custom Terumo Aortic endovascular grafts.
- Conditions
- Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
- Trial name
- TiGER (NCT04246463)
- Testing
- Thoracic, Abdominal, Custom Device
- Where
- 58 sites in United States, Belgium and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Vascutek Ltd.
Valve Disease, Heart, Atrial Fibrillation (AF)
Apixaban VS Warfarin in AF Pts First Three Months After Repair or BIO AVR MVR
SAFE-HEART is a single-centre, randomized controlled trial comparing the safety and efficiency of Apixaban versus Warfarin in the early period (3 months) after repair or bioprosthetics of the mitral and aortic valve cardiac…
- Conditions
- Valve Disease, Heart, Atrial Fibrillation (AF), Valve Replacement Surgery, Aortic Valve Surgery
- Trial name
- SAFE-HEART (NCT07434661)
- Testing
- Apixaban, Warfarin
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cardiac Surgery, Heart Surgery
Safety and Performance Evaluation of CPB Venous and Arterial Cannulas
This is a two-phase study evaluating the Eurosets arterial and venous cannulas for use during cardiopulmonary bypass (CPB) procedures. Phase 1 is a pilot study focused on assessing cannula safety.
- Conditions
- Cardiac Surgery, Heart Surgery, Cardiopulmonary Bypass, Coronary Surgery
- Trial name
- NCT07354841
- Testing
- Eurosets Venous and Arterial Cannula, Control Arterial and Venous Cannulas
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Eurosets S.r.l.
Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Demographic and Interpopulation Variations in Evaluation and Results of TAVI
The aim of the project is to evaluate demographic, clinical, and laboratory variations in patients with aortic stenosis treated with TAVI in different countries.
- Conditions
- Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation), Computed Tomography, Inflammatory Response During Cardiac Surgery
- Trial name
- DIVER-TAVI (NCT07258706)
- Testing
- laboratory biomarker analysis, Computed tomography of aortic root and aorta
- Where
- 5 sites in Italy, Poland and 3 more
- Volunteers
- 800 people
- Sponsor
- Poznan University of Medical Sciences