Clinical trials: Apathy
Schizophrenia, Apathy
Study of the Effectiveness of Mental Contrasting and Implementation Intention in the Management of Apathy in Schizophrenia
Schizophrenia is a mental pathology that concerns 1% of the French population, characterized by heterogeneity of symptoms. One of them, apathy is defined as a multidimensional psychopathological state manifested by a decrease in…
- Trial name
- COMEIA (NCT04781179)
- Testing
- CM-II, Psychoeducation
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Montpellier
Alzheimer s Disease, Alzheimer Dementia (AD)
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed…
- Conditions
- Alzheimer s Disease, Alzheimer Dementia (AD), Alzheimer Dementia, Alzheimer Disease
- Trial name
- PRIME (NCT07279740)
- Testing
- intermittent theta burst stimulation (iTBS), Methylphenidate (MPH)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer Disease and Related Dementias
Home-based tDCS for Apathy in Alzheimer's Disease
The purpose of this study is to assess feasibility, acceptability, and safety of providing tDCS to Alzheimer's disease and related dementias (ADRD) patients with apathy and to assess the efficacy of tDCS for ADRD-related…
- Trial name
- NCT04855643
- Testing
- home-based active tDCS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Drug-naïve Patients With Parkinson's Disease, Apathy
Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi-center Study
Among the psychiatric symptoms observed in the premotor phase of Parkinson's disease (PD) and/or in "de novo" patients, apathy is relatively frequent (estimated to 23%).
- Trial name
- NCT01765257
- Testing
- AZILECT®
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease, Non-motor Symptoms
Objective Assessment of Behavioural Disorders in PD
The aim of this project is to measure behavioural disorders in Parkinson's disease (PD) patients in a more objective way, in order to facilitate the detection of those symptoms and improve the treatment of non-motor symptoms in…
- Trial name
- TECHNO-PARK (NCT04611581)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Effort Based Decision Making, Prosocial Behavior
Effort and Antidepressant Study Test
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task…
- Conditions
- Effort Based Decision Making, Prosocial Behavior, Apathy
- Trial name
- EAST (NCT06696482)
- Testing
- Escitalopram 10mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
PARKINSON DISEASE (Disorder), Apathy
Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy
This clinical trial's goal is to evaluate if the IRL757 is safe and has a good tolerability in participants with Parkinson's disease and experiencing apathy (a lack of interest or motivation).
- Conditions
- PARKINSON DISEASE (Disorder), Apathy, Safety
- Trial name
- LIFT-PD (NCT07461220)
- Testing
- IRL757
- Where
- 14 sites in Bulgaria, Germany and 2 more
- Volunteers
- 75 people
- Sponsor
- Integrative Research Laboratories AB
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Apathy, Diabetes
The Role of Apathy in Glycemic Control
In spite of several new medications and insulins for the control of blood sugars in patients with diabetes, a large number of patients do not have good control.
- Trial name
- NCT00844090
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- US Department of Veterans Affairs
Apathy, Bipolar Disorder
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by…
- Trial name
- ANACONDA (NCT06914284)
- Testing
- Actigraphy and MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Apathy, Stroke
Accelerated rTMS vs. Sham for Stroke Apathy
Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them.
- Conditions
- Apathy, Stroke, Stroke Sequelae, Stroke/Brain Attack
- Trial name
- NCT07113067
- Testing
- MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active), Brainsight Neuronavigation System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder
A Study of Patients With Major Depressive Disorder and Residual Apathy
The purpose of this study is to provide a comparison of the apathy, depression, and functional outcomes associated with switching to duloxetine or escitalopram in patients who have previously responded to treatment with a…
- Trial name
- NCT00985504
- Testing
- Duloxetine, Escitalopram
- Where
- 15 sites in Australia, Canada and 3 more
- Volunteers
- 483 people
- Sponsor
- Eli Lilly and Company
Behavioral Disorder
Evaluation of the Effectiveness of the TOVERTAFEL System on Behavioral Disorders
The prevalence of behavioral disorders is high in patients living in an institutional environment or hospitalized in a long-term care unit.
- Trial name
- TOVERTAFEL (NCT04421833)
- Testing
- TOVERTAFEL, USUAL activities
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease, Apathy
Methylphenidate for Apathy in Veterans With Parkinson's Disease
Apathy is one of the most common behavioral symptoms of Parkinson's disease. Patients with apathy show diminution in motivation and goal-directed behaviors, which is a fundamental aspect of human functioning, affecting dependency…
- Trial name
- MAV-PD (NCT05669170)
- Testing
- Psychosocial intervention, Methylphenidate
- Volunteers
- 60 people
- Sponsor
- Ralph H. Johnson VA Medical Center
Apathy in Dementia
The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRD
This is a research study to test two different interventions to decrease apathy in assisted living residents with some memory issues. Apathy makes older adults not feel like doing much activity.
- Trial name
- NCT06735950
- Testing
- Volunteering in Place Program, Recreational activity
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Insulin Sensitivity, Apathy
Lifestyle Intervention for Improving Insulin Resistance and Concern for Health
The primary objective of this study is to test the effect of a diet and exercise program in older adults with insulin resistance and a motivation disorder known as apathy. The main questions the study aims to answer are: 1.
- Trial name
- NCT05649176
- Testing
- Diet without soy, Diet with soy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pennington Biomedical Research Center
Lack of; Attention, With Hyperactivity (ADHD)
Treatment Plan for ADHD With Indifferent Traits
For children with ADHD aged 4-10 at the time of enrollment, starting from preschool, focusing on apathy and emotional control, using psycho-behavioral measurements, EEG experiments, and eye tracking technology to evaluate and…
- Trial name
- NCT05075447
- Testing
- Emotion Control Treatment Program
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Amyotrophic Lateral Sclerosis
Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of central and peripheral motor neurons. ALS leads to death usually within 3 to 5 years from the onset of the symptoms.
- Trial name
- NCT03892382
- Testing
- rTMS
- Where
- Poland
- Sponsor
- Jagiellonian University
Schizophrenia, Persistent Negative Symptoms
Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation
In its 2012's release guideline on therapy for schizophrenia, the EMA joined the FDA to acknowledge primary and persistent negative symptoms (PNS) as an unmet need in the treatment of schizophrenia.
- Conditions
- Schizophrenia, Persistent Negative Symptoms, Progressive Periodic Catatonia, Aviation
- Trial name
- SP-RENESA (NCT06184165)
- Testing
- Personalized rTMS
- Volunteers
- 160 people
- Sponsor
- University Hospital, Strasbourg, France
Parkinson's Disease
Rasagiline and Apathy in Parkinson's Disease
The purpose of this study is to determine whether rasagiline is effective in the treatment of apathy in patients with Parkinson's disease.
- Trial name
- NCT00755027
- Testing
- Rasagiline
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau