Clinical trials: Apathy
Apathy, Neurocognitive Disorders
Effects of t-DCS and Cognitive Training on Apathy in Elderly With Minor Neurocognitive Impairment
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique using a low intensity electric current to modify cortical excitability.
- Trial name
- FAME3 (NCT05232877)
- Testing
- tDCS
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Schizophrenia
Validation of a Tool for the Dimensional Assessment of Apathy in a Population Suffering From Schizophrenia.
Schizophrenia affects about 1% of the world's population. According to the WHO, it was one of the ten most worrying pathologies of the twenty-first century.
- Trial name
- HANDI-AS1 (NCT03801551)
- Testing
- Validate according to psychometric criteria, a dimensional measure of apathy in a population suffering from schizophrenia spectrum disorder and other psychotic disorders (according to DSM-5 criteria).
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Niort
Schizophrenia, Schizoaffective Disorder
Positive Emotions Program for Schizophrenia (PEPS)
This study evaluates the addition of a 8 session psychological program, called Positive Emotions Program for Schizophrenia (PEPS) to improve motivation and pleasure in adults with schizophrenia.
- Trial name
- PEPS-RCT (NCT02593058)
- Testing
- Positive Emotions Program for Schizophrenia, Treatment As Usual
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Institut et Haute Ecole de la Santé la Source
Obesity, Apathy
Role of Apathy in the Effectiveness of Weight Loss Interventions
The purpose of this study is to determine whether treating apathy with methylphenidate or medical Crisis counselling will increase adherence to weight loss programs thereby increasing their effectiveness
- Trial name
- NCT00548652
- Testing
- MOVE, medical crisis councelling, methyphenidate
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- VA Nebraska Western Iowa Health Care System
Dementia
VRx@Home: Study to Evaluate VR-therapy for PwD Living at Home
The investigators are designing and rigorously evaluating the first Virtual Reality-therapy program for people with dementia (PwD) living at home, administered by their informal caregivers (family/friends).
- Trial name
- VRx@Home (NCT04988360)
- Testing
- HMD: Immersive VR, Tablet: Non-immersive VR
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease, Apathy
Targeting Apathy With Music in Parkinson's Disease
Parkinson's Disease (PD) is often accompanied by non-motor symptoms that make treatment more difficult. One such symptom is apathy (lack of motivation and emotion).
- Trial name
- NCT05505019
- Testing
- Music listening, Podcast listening
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Frontotemporal Dementia
Intranasal Oxytocin for Frontotemporal Dementia
The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no…
- Trial name
- FOXY (NCT03260920)
- Testing
- Syntocinon
- Where
- 11 sites in United States, Canada
- Volunteers
- 112 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Parkinson Disease
Apathy in Parkinson Disease TMS Study
The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1.
- Trial name
- PDTMSAPATHY (NCT06087926)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Frontotemporal Dementia, Deep Brain Stimulation
Subgenual Cingulate Deep Brain STIMulation for Apathetic Behavioral Variant FRONtotemporal Dementia
Frontotemporal dementia (FTD), the most common dementia in individuals younger than 60 years of age, has no disease-modifying treatment.
- Trial name
- FRONSTIM (NCT05699330)
- Testing
- Bilateral subgenual cingulate deep brain stimulation (SGC DBS)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Apathy, Stroke Sequelae
Accelerated rTMS for Post-Stroke Apathy
This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to…
- Conditions
- Apathy, Stroke Sequelae, Stroke (CVA) or TIA, Stroke/Brain Attack
- Trial name
- NCT05878457
- Testing
- MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Idiopathic Parkinson's Disease
Trial to Evaluate The Efficacy Of Rotigotine on Parkinson's Disease-Associated Motor Symptoms And Apathy
This trial is being conducted to assess the effects of Rotigotine over Placebo on improvement of Apathy and motor symptoms in subjects with early-stage and advanced stage idiopathic Parkinson´s Disease.
- Trial name
- BRIGHT (NCT01782222)
- Testing
- Rotigotine
- Where
- 42 sites in United States, Austria and 5 more
- Volunteers
- 122 people
- Sponsor
- UCB BIOSCIENCES GmbH
Apathy in Dementia, Aged
Benefit of Virtual Reality Headset Use on Apathy in Older Adults With Major Neurocognitive Disorders
The goal of this clinical trial is to verify that virtual reality is tolerably compatible with apathetic pathologies in patients and residents with major neurocognitive disorders.
- Conditions
- Apathy in Dementia, Aged, Virtual Reality, Neurocognitive Disorders
- Trial name
- APATHIE_RV (NCT06047522)
- Testing
- Casque Lumeen
- Where
- 6 sites in France
- Volunteers
- 30 people
- Sponsor
- RIVAGES
Alzheimer Disease, Apathy in Dementia
rTMS for Apathy Clinical Trial
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm.
- Conditions
- Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment
- Trial name
- REACT (NCT05561205)
- Testing
- rTMS, methylphenidate
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Apathy, Behavior
Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
The purpose of this study is to provide relevant quantitative evaluation of apathy close to real life situation by means of a multimodal sensor system integrated.
- Conditions
- Apathy, Behavior, Frontotemporal Dementia
- Trial name
- ECOCAPTURE (NCT02496312)
- Testing
- Evaluation of Apathy Close to Real Life Situation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease, Apathy
Move to Improve Physical Activity in Parkinson's Disease
Apathy is a multi-dimensional behavior characterized by impairments to motivation, planning and initiation; collectively called, goal-directed behavior.
- Trial name
- MoTIvatE (NCT04051151)
- Testing
- Gameficiation
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Pennsylvania
Depression
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or…
- Trial name
- NCT00183729
- Testing
- Memantine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Eric Lenze
Stroke, Ischemic
Ready, Set, Goal: Motivation and Cognition in Stroke Patients
Apathy is a syndrome of reduced motivation, characterized by diminished goal-directed behaviours (e.g., lack of effort), decreased goal-oriented cognitions (e.g., lack of interest) and blunted affect.
- Trial name
- ACE (NCT03511300)
- Testing
- Goal-Setting Instructions, Standard Instructions
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke
Characterizing the Neural Bases of Motivational Disorders After Stroke
The aim of the study is to quantify elementary mechanisms of motivation, with innovative tools adapted to clinical settings, in healthy subjects, and in stroke patients.
- Trial name
- MOTI-stroke (NCT03741140)
- Testing
- Motivation tests
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease
Ecological Assessment of Apathy in Alzheimer's Disease and in Control Subjects: Video Recognition and Actigraphy
Cognitive and memory disorders are characterized of Alzheimer disease. In addition, psychologic and behavioural symptoms, called speak neuropsychiatric symptoms, are frequents and play an important role in prognostic and…
- Trial name
- NCT01384344
- Testing
- observational
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alzheimer's Disease, Apathy
Repetitive Transcranial Magnetic Stimulation for Apathy Treatment in Alzheimer's Disease
We aim to evaluate the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for apathy treatment in patients with Alzheimer's disease (AD).
- Trial name
- NCT01885806
- Testing
- Magnetic Stimulator Magstim Rapid 2
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais