Clinical trials: Apathy in Dementia
Apathy in Dementia
The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRD
This is a research study to test two different interventions to decrease apathy in assisted living residents with some memory issues. Apathy makes older adults not feel like doing much activity.
- Trial name
- NCT06735950
- Testing
- Volunteering in Place Program, Recreational activity
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Apathy, Behavior
Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated.
The purpose of this study is to provide relevant quantitative evaluation of apathy close to real life situation by means of a multimodal sensor system integrated.
- Conditions
- Apathy, Behavior, Frontotemporal Dementia
- Trial name
- ECOCAPTURE (NCT02496312)
- Testing
- Evaluation of Apathy Close to Real Life Situation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Apathy, Apathy in Dementia
SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study
SENS'REM is a pilot feasibility study evaluating a new non-drug therapeutic program based on multisensory reminiscence using immersive virtual reality in older adults living in nursing homes or long-term care units who present…
- Trial name
- SENS'REM (NCT07468305)
- Testing
- Multisensory Virtual Reality Reminiscence Intervention
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Apathy, Behavioral Variant Frontotemporal Dementia (bvFTD)
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
Apathy is defined as a quantitative reduction in voluntary and goal-directed behavior. To address this, the investigators propose an ethological approach to assess apathy objectively and quantitatively by observing patients in…
- Conditions
- Apathy, Behavioral Variant Frontotemporal Dementia (bvFTD), Disinhibition, Depression - Major Depressive Disorder
- Trial name
- ECOCAPTURE (NCT03272230)
- Testing
- ECOCAPTURE, Cognitive and Behavioral experimental tasks, Neuropsychological assessment
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Apathy, Apathy in Dementia
Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)
The goal of this trial is to learn whether home-based robotic interventions can reduce apathy in people with cognitive decline. Apathy means reduced motivation, interest, or initiative in daily life.
- Trial name
- RAPHAel (NCT07404410)
- Testing
- telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- Giovanna Zamboni
Alzheimer Disease, Apathy in Dementia
rTMS for Apathy Clinical Trial
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm.
- Conditions
- Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment
- Trial name
- REACT (NCT05561205)
- Testing
- rTMS, methylphenidate
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Apathy in Dementia
A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy
The purpose of this study is to determine whether CVL-871 is safe and tolerable in patients with Dementia-Related Apathy and if CVL-871 shows changes in clinical measurements of apathy.
- Trial name
- NCT04958031
- Testing
- CVL-871 1.0 mg, CVL-871 3.0 mg
- Where
- 20 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- AbbVie
Neurocognitive Disorders, Mild, Cognitive Impairment, Mild
Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders
This study aims to observe the effects of daily personalized digital reminiscence sessions, conducted with the help of a digital conversational agent, and to determine whether these sessions lead to improvements in symptoms such…
- Conditions
- Neurocognitive Disorders, Mild, Cognitive Impairment, Mild, Depression Mild, Apathy
- Trial name
- NCT07237009
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- KompanionCare SAS
Alzheimer s Disease, Alzheimer Dementia (AD)
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed…
- Conditions
- Alzheimer s Disease, Alzheimer Dementia (AD), Alzheimer Dementia, Alzheimer Disease
- Trial name
- PRIME (NCT07279740)
- Testing
- intermittent theta burst stimulation (iTBS), Methylphenidate (MPH)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer Disease, Apathy in Dementia
TMS as a Treatment for Apathy in Alzheimer's Disease
This proposal will demonstrate that non-invasive brain stimulation is able to modulate cortico-striatal circuits in neurodegenerative patients with apathy, and that doing so results in circuit-specific increases in FC and DA…
- Trial name
- NCT05389644
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Alzheimer's Disease
Improving Function, Quality of Life, Glycemia in Diabetics With Dementia
The primary purpose of this study is to determine if the study medication Methylphenidate (Ritalin) will improve subject's blood-sugar control by improving their motivation more than placebo.
- Conditions
- Diabetes Mellitus, Alzheimer's Disease, Apathy, Dementia
- Trial name
- NCT00792662
- Testing
- Methylphenidate
- Sponsor
- University of Nebraska
Alzheimer Disease 10, Dementia
Cognitive Stimulation Therapy
The concept of cognitive stimulation in AD is one of the most popular approaches. Cognitive Stimulation Therapy (CST) is stated to be evidence-based best practice with robust clinical trials, administered according to specific…
- Conditions
- Alzheimer Disease 10, Dementia, Apathy, Anxiety
- Trial name
- NCT05808530
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Hasan Kalyoncu University
Apathy in Dementia, Aged
Benefit of Virtual Reality Headset Use on Apathy in Older Adults With Major Neurocognitive Disorders
The goal of this clinical trial is to verify that virtual reality is tolerably compatible with apathetic pathologies in patients and residents with major neurocognitive disorders.
- Conditions
- Apathy in Dementia, Aged, Virtual Reality, Neurocognitive Disorders
- Trial name
- APATHIE_RV (NCT06047522)
- Testing
- Casque Lumeen
- Where
- 6 sites in France
- Volunteers
- 30 people
- Sponsor
- RIVAGES
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Apathy, Alzheimer's Dementia
Repetitive Transcranial Magnetic Stimulation for Apathy in Alzheimer's Dementia
Alzheimer's Dementia (AD) is a major public health problem. Apathy, a profound loss of motivation, is seen in majority of patients with AD.
- Trial name
- NCT02190084
- Testing
- Neurostar repetitive transcranial magnetic stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Central Arkansas Veterans Healthcare System
Dementia, Accidental Falls
Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.
Falls in the elderly are a very common and serious health problem with devastating consequences. Those with dementia are 5 times more likely to experience falls than older people without significant cognitive impairment.
- Conditions
- Dementia, Accidental Falls, Apathy
- Trial name
- NCT01825577
- Testing
- Transdermal Methylphenidate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- St. Louis University
Emotions, Dementia
Dementia Associated Apathy.
We want to determine if patients with dementia show any kind of emotion while they look at a defined selection of photos. These are photos taken from a international image-platform and mixed with photos (biographic) that show…
- Conditions
- Emotions, Dementia, Apathy
- Trial name
- NCT03293537
- Testing
- Skin conductance and Heart rate measurement
- Where
- Switzerland
- Volunteers
- 133 people
- Sponsor
- Zurich University of Applied Sciences
Apathy, Alzheimer's Disease
Apathy in Dementia Methylphenidate Trial (ADMET)
The Apathy in Dementia Methylphenidate Trial (ADMET) is a masked, placebo-controlled trial that will examine the efficacy and safety of methylphenidate for the treatment of clinically significant apathy in patients with…
- Trial name
- ADMET (NCT01117181)
- Testing
- Methylphenidate, Psychosocial intervention
- Where
- 3 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Apathy in Dementia
Bupropion for the Treatment of Apathy in Alzheimer's Dementia
Apathy in dementia prevents successful application of non-pharmacological treatments, accelerates cognitive and functional decline and increases disease-related costs by earlier need for full-time care.
- Trial name
- APA-AD (NCT01047254)
- Testing
- Elontril
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bonn
Alzheimer's Disease, Apathy
Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study
The purpose of the study is to determine the efficacy of methylphenidate over placebo in treating apathy in patients with Alzheimer's dementia.
- Conditions
- Alzheimer's Disease, Apathy, Dementia
- Trial name
- NCT00495820
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development