Clinical trials: Aphasia, Nonfluent
Primary Progressive Aphasia
Language in Primary Progressive Aphasia
The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.
- Trial name
- NCT00537004
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Northwestern University
Stroke, Aphasia
Effects of rTMS Based on Brain Activation During Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of high or low-frequency repetitive transcranial magnetic stimulation based on brain activation with functional near infrared spectroscopy in poststroke…
- Trial name
- NCT02556385
- Testing
- High frequency rTMS, Low frequency rTMS
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Bundang Hospital
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley
Aphasia, Acquired, Aphasia
Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia
The goal of this clinical trial is to establish the feasibility and fidelity of a high-intensity exercise program for individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia Non Fluent
- Trial name
- NCT06185023
- Testing
- Low-intensity physical exercise, High-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of California, Berkeley
Aphasia, Broca's Aphasia
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia…
- Trial name
- STARS (NCT07688551)
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of South Carolina
Broca's Aphasia
Virtual Reality Based Sensorimotor Speech Therapy
The purpose of this study is to determine whether VR based language rehabilitation scenario based on the core premises of ILAT has a beneficial effect on the linguistic performance (faster retrieval of the target lexicon and…
- Trial name
- NCT02928822
- Testing
- VR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Universitat Pompeu Fabra
Non Fluent Aphasia in Subacute Stroke
Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
To investigate the therapeutic effect of dual hemisphere repetitive transcranial magnetic stimulation (rTMS) on post-stroke non fluent aphasia.
- Trial name
- NCT01850836
- Testing
- repetitive transcranial magnetic stimulation
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Assiut University
Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American…
- Conditions
- Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT04363684
- Where
- 26 sites in United States, Canada
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Non-fluent Aphasia, Glioma
High-frequency nrTMS on the Contralateral Broca Mirror Area for Glioma Patients With Early Postoperative Aphasia
The goal of this randomized clinical controlled trial is to determine whether the application of high frequency neuronavigated repetitive transcranial magnetic stimulation (nrTMS) on the contralateral of Broca's area can…
- Trial name
- NCT05788445
- Testing
- nrTMS treatment
- Volunteers
- 48 people
- Sponsor
- Beijing Neurosurgical Institute
Aphasia, Broca
Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients
Aphasia is one of the most disabling complications in language production in patients with left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously recovery after several weeks or months.
- Trial name
- Aphasia-ACV (NCT02241213)
- Testing
- Transcranial Magnetic Stimulation (TMS-r)
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Cardiovascular de Colombia
Aphasia, Aphasia Non Fluent
Speech Entrainment for Aphasia Recovery
After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia.
- Conditions
- Aphasia, Aphasia Non Fluent, Stroke
- Trial name
- SpARc (NCT04364854)
- Testing
- SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Medical University of South Carolina
Predicted Tauopathies, Including, Progressive Supranuclear Palsy
Davunetide (AL-108) in Predicted Tauopathies - Pilot Study
The primary objective of the study is to obtain preliminary safety and tolerability data with davunetide (NAP, AL-108) in patients with a tauopathy (frontotemporal lobar degeneration [FTLD] with predicted tau pathology…
- Conditions
- Predicted Tauopathies, Including, Progressive Supranuclear Palsy, Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17, Corticobasal Degeneration Syndrome
- Trial name
- NCT01056965
- Testing
- davunetide (AL-108, NAP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Nonfluent Aphasia, Stroke
Augmenting Language Therapy for Aphasia: Levodopa
The purpose of this study is to evaluate the effectiveness of the medication levodopa, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e.
- Trial name
- NCT01429077
- Testing
- levodopa/carbidopa
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Aphasia, Non-fluent
Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- REMAP (NCT04102228)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Stroke Rehabilitation, Aphasia, Broca
Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation
The goal of this Interventional Study is to develop and test the Indian Adaptation of Melodic Intonation Therapy (MIT) for Indian patients in with post-stroke Non-Fluent Aphasia (PSNFA).
- Trial name
- NCT06323330
- Testing
- Speech rehabilitation
- Where
- 3 sites in India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Aphasia, Stroke
Galantamine Treatment for Nonfluent Aphasia in Stroke Patients
Cognitive impairment after stroke is common and has a major effect on morbidity and quality of life. Acetylcholinesterase inhibitors have demonstrated benefit in vascular dementia, but efficacy in treating more circumscribed…
- Trial name
- NCT01129479
- Testing
- Galantamine
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Stroke, Broca's Aphasia
Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia.
The primary objective of this feasibility study is to evaluate the safety and effectiveness of targeted sub-threshold epidural cortical stimulation delivered concurrent with speech-language rehabilitation activities to enhance…
- Trial name
- NCT00170703
- Testing
- Cortical Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Northstar Neuroscience
Stroke
Dextroamphetamine and tDCS to Improve the Fluency
The proposed study aims to evaluate safety and efficacy of combined dextroamphetamine (Dexedrine) and transcranial direct current stimulation (tDCS) with melodic intonation therapy (MIT) for treatment of aphasia after stroke.
- Trial name
- NCT02514044
- Testing
- Dexedrine, Active tDCS, Speech Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Primary Progressive Aphasia, Nonfluent Progressive Aphasia
Language Treatment for Progressive Aphasia
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking.
- Conditions
- Primary Progressive Aphasia, Nonfluent Progressive Aphasia, Semantic Dementia
- Trial name
- NCT00957710
- Testing
- Errorless learning
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baycrest
Aphasia, Broca
Effects of PACE Technique in Patients With Aphasia
Aphasia, a communication disorder often resulting from him brain injury such as stroke, impacts an individual's ability to understand or produce language.
- Trial name
- NCT07521098
- Testing
- experimental, control group conventional therapy
- Where
- Pakistan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Riphah International University