Clinical trials: Aphasia Rehabilitation
Stroke, Acute, Expressive Aphasia
Music After Stroke To Enhance Rehabilitation
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities.
- Conditions
- Stroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive Disorder
- Trial name
- MASTER (NCT04441515)
- Testing
- Ipod with music, ipod with books to listen, ipod only with usual care
- Volunteers
- 12 people
- Sponsor
- Pace University
Chronic Aphasia
Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study
This Phase II study aims to ascertain the effectiveness of HD-tDCS for adjunctive treatment of anomia in chronic aphasia post stroke.
- Trial name
- NCT02540109
- Testing
- HD-tDCS (Soterix Medical, Active)
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Soterix Medical
Chronic Aphasia
Computerised Therapy in Chronic Stroke
The few studies looking systematically into the neurophysiological and neuropsychological components of available therapies for chronic aphasia are highly heterogeneous in nature.
- Trial name
- CATChES (NCT01928602)
- Testing
- TherAppy Language App, Mind-Games
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Aphasia, Stroke
Cerebellar Brain Stimulation Plus Language Therapy for People at Risk of Poor Aphasia Recovery After Stroke
This pilot study tests whether a mild form of brain stimulation to the cerebellum, combined with computer-based language therapy, helps people recover language after a stroke when a poor natural recovery is predicted.
- Conditions
- Aphasia, Stroke, Anomia
- Trial name
- PART-CN (NCT07912242)
- Testing
- Cathodal cerebellar transcranial direct current stimulation, Computerized language therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Aphasia
Efficacy of Low-frequency rTMS in Aphasia
In a randomized controlled trial, efficacy of low-frequency, inhibitory rTMS will be examined in rehabilitation of acquired aphasia.
- Trial name
- NCT05450341
- Testing
- rTMS over right frontal target, rTMS over right temporal target
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Anomic Aphasia
Virtual Reality Training for Aphasia Rehabilitation
Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language.
- Trial name
- Aphasia360 (NCT05793879)
- Testing
- Video 360, Standard videos
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Aphasia, Stroke
Adaptive Trial Scheduling in Naming Treatment for Aphasia
Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life.
- Trial name
- NCT05653466
- Testing
- Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition, Low-Item Non-Adaptive Spacing Condition
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Consciousness Disorders, Severe Acquired Brain Injury
Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)
Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard…
- Trial name
- NCT07711119
- Testing
- Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA)
- Where
- 4 sites in Italy
- Volunteers
- 79 people
- Sponsor
- Alfonso Magliacano
Aphasia, Stroke
Intention Treatment for Anomia
Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia).
- Trial name
- NCT04267198
- Testing
- Intention Treatment for Anomia
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Aphasia, Stroke
Aphasia Rehabilitation: Modulating Cues, Feedback & Practice
The purpose of this study is to evaluate how changing different conditions of the speech-language treatment (such as cues, feedback, complexity and practice schedule) affects the language outcome of study subjects with aphasia…
- Trial name
- NCT01597037
- Testing
- Script training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia, Acquired
Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke
Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment.
- Trial name
- ORACLE (NCT03287544)
- Testing
- Combined rehabilitation, Linguistic rehabilitation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Toulouse
Aphasia, Language Disorders
Evaluation of the Effects of Response Elaboration Training for Aphasia
The purpose of this study is to evaluate the effects of Response Elaboration Training (RET), which is a speech/language therapy for aphasia.
- Conditions
- Aphasia, Language Disorders, Speech Disorders
- Trial name
- NCT00125216
- Testing
- Response Elaboration Training
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Strategy Training
Strategy Training for People With Aphasia After Stroke
One-third to one-half of acute strokes result in newly acquired cognitive impairments. Approximately 30 to 40% of people in the acute phase of stroke also sustain communication impairments.
- Trial name
- NCT03593876
- Testing
- Strategy Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Aphasia, Acquired, Stroke
Rehabilitation of Post-stroke Aphasia by Targeting Phonological, and Lexico-semantic Deficits With Speech Output Tasks
Aphasia in brain-damaged adult patients refers "to the more or less complete loss of the ability to use language" resulting from acquired brain damage, typically of the left hemisphere.
- Conditions
- Aphasia, Acquired, Stroke, Anomia
- Trial name
- PHOLEXSEM (NCT06451731)
- Testing
- PHOLEXSEM, PACE
- Volunteers
- 44 people
- Sponsor
- Istituto Auxologico Italiano
Stroke
Cerebellar Stimulation for Aphasia Rehabilitation
The optimal site of neuromodulation for post-stroke aphasia has yet to be established. This study will investigate whether multiple sessions of cerebellar transcranial direct current stimulation (tDCS) boosts language therapy in…
- Trial name
- CeSAR (NCT05093673)
- Testing
- Cathodal Cerebellar tDCS, Semantic Feature Analysis (SFA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Aphasia, Cerebrovascular Accident
Treating Intention In Aphasia: Neuroplastic Substrates
The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories.
- Trial name
- NCT00567242
- Testing
- Word-finding with intention component, Word-finding with no intention component
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Stroke, Aphasia
Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke.
- Trial name
- MOTOLANG-AVC (NCT05776368)
- Testing
- Syntactic comprehension battery (BCS), Montreal Cognitive Assessment (MOCA), Purdue Pegboard Test
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Aphasia
Combining Language Therapy With rTMS in Aphasia
With the present RCT, the investigators aimed at finding an optimal protocol for the neurorehabilitation of chronic post-stroke aphasia by combining two promising methods, ILAT (Intensive language action therapy) and 1-Hz rTMS to…
- Trial name
- ILAT+rTMS (NCT03629665)
- Testing
- Intensive Language-Action Therapy (ILAT), Repetitive navigated Transcranial Magnetic Stimulation during naming training
- Volunteers
- 17 people
- Sponsor
- Paula Heikkinen
Stroke-induced Aphasia
Overcoming Learned Non-Use in Chronic Aphasia
In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech.
- Trial name
- NCT02012374
- Testing
- Intensive Language Action Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Stroke
Treatment for Word Retrieval Impairments in Aphasia
In this study the investigators are examining the effectiveness of two different speech therapy protocols for word retrieval impairments experienced by individuals with stroke-induced aphasia.
- Trial name
- NCT00764400
- Testing
- Word Retrieval Treatments for Aphasia
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Old Dominion University