Clinical trials: Apical Periodontitis
Healthy
Antibacterial Effect of NaOCl With Etidronic Acid in Apical Periodontitis Treatment
Sodium hypochlorite (NaOCl), the most commonly used irrigation solution during chemomechanical preparation, plays a significant role in eliminating bacteria within root canals.
- Trial name
- NCT06597825
- Testing
- root canal irrigation solutions (NaOCl+EDTA, NaOCl+HEDP)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Symptomatic Irreversible Pulpitis
Effect of Cryotherapy on Postoperative Pain
the aim of the study is to evaluate the effect of cryotherapy on postoperative pain in molar teeth with irreversible pulpitis and apical periodontitis
- Trial name
- NCT03716635
- Testing
- cryotherapy, normal saline
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Periodontitis
Association of Apical Periodontitis With Hs-CRP and Hemogram Indices
There is lack of evidence on resolution of signs of systemic inflammatory markers by successful elimination of periapical inflammation by endodontic treatment.
- Trial name
- NCT04980768
- Testing
- Root canal treatment
- Where
- India
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Disease
Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth
The patients will be randomly assigned into two equal groups Group : OneShape Group: ProtaperNext Endodontics procedure steps: Patient will be anesthetized by using infiltration local anesthesia or nerve block according to the…
- Trial name
- RCT2019 (NCT04200638)
- Testing
- ProTaper Next
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Post Operative Pain, Inflammation
The Effect of Intra Oral Cryotherapy in Patients With Symptomatic Apical Periodontitis
The participants were divided into two groups: Group I (cryotherapy) (n =10) after the completion of the mechanical preparation intra oral cryotherapy was applied.
- Trial name
- NCT06082479
- Testing
- intraoral cryotherapy,ice gel
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Radiographic Healing of Periapical Lesions Following Ultrasonic Activation of Heated Sodium Hypochlorite Without Instrumentation of Root Canals
Minimally Invasive Root Canal Treatment With Active Disinfection on Single Rooted Teeth With Periapical Lesions
A novel form of root canal treatment RCT, referred as minimally invasive endodontics MIE, has emerged recently to adopt a unique approach that emphasize reducing tooth structural changes post-treatment (32).
- Trial name
- NCT06467643
- Testing
- non-instrumented root canal treatment with passive ultrasonic activation of heated sodium hypochlorite, conventional root canal treatment with passive ultrasonic activation of heated sodium hypochlorite
- Where
- Lebanon
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Microbial Colonization
Investigate"Clinically" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis
The objective of this study is to investigate "clinically" the effectiveness of Boswellia based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of…
- Trial name
- NCT06466538
- Testing
- Calcium hydroxide, Leddermix, Boswellia
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Apical Periodontitis
Sclerostin Regulation in Apical Periodontitis Lesions in Apical Periodontitis Lesions
Our aim was to examine the relationship between inflammatory bone resorption associated with the severity of AP and gingival crevicular fluid (GCF) and blood sclerostin and PGE2 levels in cases of AP.
- Trial name
- NCT06512103
- Testing
- Apical periodontitis group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Kidney Diseases, Periapical Lesions
Association of Apical Periodontitis With Chronic Kidney Disease
This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy…
- Trial name
- NCT05818657
- Testing
- levels of CKD markers, Oral health status, apical periodontitis, systemic inflammatory marker, Oral health status, apical periodontitis
- Where
- India
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Root Canal Infection, Pain, Postoperative
Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the effect of low-level laser therapy (LLLT) and intracanal cryotherapy applications on postoperative pain in endodontic interventions of primary molar teeth with apical periodontitis.
- Conditions
- Root Canal Infection, Pain, Postoperative, Cryotherapy Effect, Laser
- Trial name
- NCT05476445
- Testing
- Control, Laser, Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Non Vital Teeth, Persistent Symptomatic Apical Periodontitis
To Evaluate and Compare the Effect of Orthograde and Retrograde MTA Root End Filling After Periapical Surgery in Posteriors
To evaluate and compare the effect of orthograde and retrograde MTA root end filling on clinical, 2D and 3D radiographic success and quality of life after periapical surgery in posteriors- A Randomised Control Trial
- Trial name
- NCT07808424
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Asymptomatic Apical Periodontitis
Comparison of the Effects of Bio Ceramic and Epoxy Resin-based Sealers on Postoperative Pain After Root Canal Treatment
This study aims to compare the effect of bio ceramic sealer and resin-based sealer on the intensity and occurrence of post operative pain in single rooted teeth with asymptomatic apical periodontitis.
- Trial name
- NCT06543004
- Testing
- AH plus sealer, Bioceramic sealer
- Where
- Qatar
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Primary Health Care Corporation, Qatar
Periapical Periodontitis
Adrenomedullin Upregulation in Apical Periodontitis
The aim of the present study was to investigate the relationship between Apical periodontitis (AP) severity and inflammatory markers (IL-12, TNF-alpha), and Mid-Regional Pro Adrenomedullin (MR-proADM) in patients with AP.
- Trial name
- NCT05297747
- Testing
- Apical periodontitis, Chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pulp Necroses, Apical Periodontitis
"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial.
- Conditions
- Pulp Necroses, Apical Periodontitis, Pulp Disease, Dental
- Trial name
- NCT06129643
- Testing
- Conventional group, Dual laser group, Combined group
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Post Operative Pain
Effectiveness of Cryotherapy on Endodontic Pain
This is a randomized , prospective , control trial to assess the effectiveness of intracanal cryotherapy on post operative pain after root canal treatment in patients with symptomatic apical periodontitis
- Trial name
- Cy (NCT06785753)
- Testing
- Irrigation Solution
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pulp and Periapical Tissue Disease
Gingival Crevicular Fluid Biomarkers and Healing After Root Canal Treatment in Asymptomatic Apical Periodontitis
This prospective observational cohort study will evaluate whether changes in gingival crevicular fluid osteoprotegerin (OPG) , RANKL/OPG ratio ,IL10,IL8and CxCL10 after primary nonsurgical root canal treatment are associated with…
- Trial name
- NCT07468643
- Testing
- Primary Nonsurgical Root Canal Treatment
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu