Clinical trials: Apical Periodontitis
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Acute Apical Periodontitis of Pulpal Origin
Assessment of Masseter Muscle With Ultrasonography
In teeth that remain decayed for a long time, the muscles in that area atrophy because the patient cannot use the decayed area much. As a result, muscle length and mass decrease.
- Trial name
- NCT06734559
- Testing
- Patients who have not antibiotic treatment for acute apical periodontitis in the last month and have not taken any anti-inflammatory medication in the past 24 hours., patients who have not acute apical periodontitis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection
- Trial name
- NCT05718596
- Testing
- sweeps laser to use irrigation activation, PUI to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Apical Periodontitis, Postoperative Pain
Effect of Diode Laser on Post-operative Pain After Endodontic Treatment in Teeth With Apical Periodontitis
Aim: This study aims to assess the effect of root canal disinfection with a 980 µm diode laser following chemomechanical root canal preparation on the severity of pain after root canal treatment (RCT).
- Trial name
- NCT04486196
- Testing
- Medency Primo Diode Laser Device (Medency, Vicenza, Italy), 2.5% NaOCl, %17 EDTA, Distilled water, 30-gauge, side-opening needle (Canal Clean, Biodent, South Korea),
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periapical Periodontitis
Research of Revascularization in Immature Teeth With Periapical Periodontitis
Revascularization is an alternative new treatment of immature permanent teeth with necrotic pulp nowadays while apexification is the traditional therapy.
- Trial name
- NCT01799187
- Testing
- revascularization, apexification
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Junqi Ling
Apical Periodontitis
Effect of Different Instrumentation Technique on Endodontic Outcome
Aim: To evaluate and compare the outcome of primary endodontic treatment following use of different instrumentation techniques. Materials and methods: Study subjects were recruited from the pool of patients referred for the…
- Trial name
- NCT03278054
- Testing
- Root Canal Treatment with hand instruments, Root canal treatment with Protaper instruments, Root canal treatment with hybrid instrumentation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pain
Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment.
Aim to compare Incidence of flare-ups and apical healing after single-visit or two-visits treatment of teeth with necrotic pulp and apical periodontitis after a two-year control period.
- Trial name
- FlareUp (NCT02815189)
- Testing
- Ibuprofen for post operative pain, Acetaminophen 325 mg for Flare up
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Apical Periodontitis
Effect of Various Sealers on Healing of Teeth With Apical Periodontitis
This study will compare the effect of three different sealers on healing of teeth with apical periodontitis after primary root canal treatment.
- Trial name
- NCT03397875
- Testing
- Zinc oxide based sealer, Epoxy resin based sealer, Bioactive silicone based sealer
- Where
- India
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Post Operative Pain, Chronic Apical Periodontitis of Pulpal Origin
The Effect of Using Reciprocal Files Alone and With Different Files on Postoperative Pain
This study aims to investigate the effects of using the Wave One Gold file alone and in combination with different files on postoperative pain in patients with asymptomatic apical periodontitis.
- Trial name
- NCT06833515
- Testing
- one flare+wave one gold glider+wave one gold, wave one gold glider+wave one gold, wave one gold
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Harran University
Apical Periodontitis, Dental Pulp Necrosis
Postoperative Pain and PTN and Reciproc
In this clinical trial, the researchers will investigate the effect of single-file reciprocating file system (Reciproc) versus multi-file rotational file systems (ProTaper Next) on the postoperative pain in adult patients who…
- Trial name
- NCT03380585
- Testing
- Reciprocating single-file system, Rotational multi-file system.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Apical Periodontitis, Assessment, Pain
Reciprocation vs Rotational Single-file Systems in Postoperative Pain
In this study, the researchers will investigate the effect of single-file reciprocating versus single-file rotational file systems on the postoperative pain in adult patients who have necrotic pulp and apical periodontitis.
- Conditions
- Apical Periodontitis, Assessment, Pain, Dental Pulp Necrosis
- Trial name
- NCT02929511
- Testing
- Reciprocating single-file system, Rotational single-file system., Active comparator Protaper multi-file system
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Pulpitis - Irreversible
Intraligmentary Dexamethasone in Lower First Molars With Irreversible Pulpitis and Apical Periodontits
Using intraligmentary dexamethasone to reduce the pain intensity during and after root canal preparation
- Trial name
- NCT05928611
- Testing
- Inferior alveolar nerve block with dexamethasone, Buccal infiltratation with dexamethasone, Inferior alveolar nerve block
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain
Comparative Evaluation of the Efficacy of Intraoral Cryotherapy Versus Intracanal Cryotherapy on Postoperative Pain
The aim of this study is to clinically compare the efficacy of intraoral cryotherapy versus intracanal cryotherapy after single visit root canal therapy in lower molars with irreversible pulpitis and symptomatic apical…
- Trial name
- NCT05041738
- Testing
- Intraoral Cryotherapy, Intracanal Cryotherapy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Inflammation
Clinical and Biochemical Effects Of Cryotherapy Protocols On Mandibular Premolars With Symptomatic Apical Periodontitis
Pain is the major reason for patients' visits to dental clinics.Medications have side effects. Treatments including cryotherapy have been suggested to prevent these side effects.This study will compare the effect of oral and…
- Trial name
- NCT07138365
- Testing
- oral Cryotherapy, Intra radicular Cryotherapy, cold irrigation
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Effect of Photobiomodulation Using Diode Laser
The Effect of Photobiomodulation Using Low-Level Diode Laser Therapy on Postoperative Pain in Symptomatic Lower Molar Teeth With Irreversible Pulpitis and Apical Periodontitis; a Randomized Controlled Clinical Trial
this study aims to assess the effect of photobiomodulation using low-level diode laser therapy on postoperative pain after single-visit root canal treatment of mandibular molars with symptomatic irreversible pulpitis and apical…
- Trial name
- NCT06396130
- Testing
- Photobiomodulation by low level diode laser, Mock Laser Application
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament
This is a Pilot Phase III single-blind randomized controlled clinical trial in patients, aged 18 years and older, presenting with symptoms of apical periodontitis.
- Trial name
- NCT03700788
- Testing
- Chlorhexidine, Calcium Hydroxide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Postoperative Pain
Occlusal Reduction and Postoperative Pain
The purpose of this randomized clinical study was to evaluate the impact of occlusal reduction on the incidences of post-instrumentation and post-obturation pain. Forty four patients were included in this study.
- Trial name
- NCT03117062
- Testing
- occlusal reduction
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Trauma
Revitalization of Traumatized Immature Permanent Teeth
This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining/regaining…
- Trial name
- NCT06043453
- Testing
- revitalization
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Post Operative Pain, Apical Periodontitis
Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth
This randomized clinical trial aimed to evaluate post-operative pain (PP) in single-rooted teeth with asymptomatic apical periodontitis following final irrigation with sonic activation systems (EDDY and EndoActivator), with and…
- Conditions
- Post Operative Pain, Apical Periodontitis, Asymptomatic Infections
- Trial name
- NCT07170098
- Testing
- EDDY sonic irrigation system, EndoActivator (EA) sonic irrigation system, 980-nm diode laser
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University