Clinical trials: Apical Periodontitis, open to volunteers
Diabete Type 2
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Methodology Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used.
- Trial name
- NCT07549373
- Testing
- 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Sharda University
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Apical Periodontitis
Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment
This study will compare three methods of activating the final irrigation solution in reducing living bacteria inside the root canals of teeth that require root canal retreatment because of apical periodontitis, an inflammatory…
- Trial name
- NCT07903285
- Testing
- Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Inonu University
Apical Periodontitis
Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
The relationship between different root canal irrigation techniques and pain after root canal treatment
- Trial name
- NCT07599254
- Testing
- root canal irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periapical Periodontitis, Dental Pulp Necrosis
Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars
This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal.
- Trial name
- IMAP-Pain (NCT07239752)
- Testing
- Patency Group, Standard Root Canal Instrumentation
- Volunteers
- 48 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Periapical Lesion Healing, Apical Periodontitis
The Effect of Different Intracanal Medicaments on Periapical Lesion Healing
This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment.
- Trial name
- NCT07237620
- Testing
- Diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Pulp Necrosis, Apical Periodontitis
The Effect of Different Intra-canal Medications on Postoperative Pain
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients…
- Trial name
- NCT07603934
- Testing
- ibuprofen, Nitrofurantoin, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulps With no Apical Periodontitis
Influence of Continuous Rotation Versus Reciprocation Motion of MG3 Blue Rotary File on Postoperative Pain and Intracanal Bacterial Reduction of Teeth With Necrotic Pulps.
he main objective of this study is to compare the impact of two different file motions-continuous rotation versus reciprocation-using the same endodontic file system (MG3 Blue rotary files) on postoperative pain and the amount of…
- Trial name
- NCT07916987
- Testing
- Engine driven files utilized in reciprocation motion, engine driven rotary files utilized in continuous rotation motion
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled Trial
This randomized controlled trial aims to compare postoperative pain after root canal treatment using two different types of ProTaper file systems: manual (hand-held) and rotary (engine-driven).
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis, Postoperative Pain After Endodontic Treatment
- Trial name
- NCT07887087
- Testing
- ProTaper Manual Root Canal Instrumentation, ProTaper Rotary Root Canal Instrumentation
- Volunteers
- 200 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Pulp Disease, Dental, Pulp Necrosis
Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial
The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and…
- Conditions
- Pulp Disease, Dental, Pulp Necrosis, Pulp Therapy in Primary Molars, Primary Teeth
- Trial name
- CTZ- emergency (NCT07542639)
- Testing
- CTZ Paste, ZOE Pulpectomy
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo
Periapical Periodontitis
Comparison of Root Canal Desinfection Protocols
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
- Trial name
- NCT07439614
- Testing
- Desinfection device, Analytical microbiological methods
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Periapical Diseases
Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT
A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each.
- Trial name
- NCT07598188
- Testing
- Saline 0.9% (1.5-2.5°C)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Islamabad Medical and Dental College
Chronic Apical Periodontitis
Effect of Different Sealers and Activation Methods on Pain
In this study, the effects of different irrigation agitation methods and different root canal filling sealers on postoperative pain after root canal treatment will be evaluated.
- Trial name
- NCT06860191
- Testing
- Root Canal Sealants
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Chronic Apical Periodontitis
Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection.
- Trial name
- NCT07892690
- Testing
- Cyperus articulatus
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Intervention Studies, ASA Physical Status I
Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases
The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications: 1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite 2. Calcium Silicate 3.
- Conditions
- Intervention Studies, ASA Physical Status I, Intracanal Medication, Periapical Abscess
- Trial name
- RCT (NCT07641933)
- Testing
- Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Apical Periodontitis
Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis
To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician…
- Trial name
- PoCT ELISA (NCT06701266)
- Testing
- Point of Care Test
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Manipal University College Malaysia
Chronic Apical Periodontitis
In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers
A randomized controlled trial was conducted to compare the treatment efficacy of iRoot SP and nRoot SP Root Canal Sealer Materials in patients with chronic apical periodontitis.
- Trial name
- NCT07388901
- Testing
- iRoot SP, nRoot SP
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Pulpitis - Irreversible
The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars
This study aims to evaluate the effect of prognostic factors, such as the severity of pulpal inflammation, carious pulp exposure, and the presence of apical periodontitis, on the success of full pulpotomy in mature permanent…
- Trial name
- NCT07340606
- Testing
- Conventional root canal treatment, Full pulpotomy
- Where
- 2 sites in Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Misr International University
Apical Periodontitis
Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated…
- Trial name
- NCT07856186
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University